If you mean complete ego death like DMT, then above 500mcg. I believe that the most recent LSD I have taken has been about 250 per hit, the vial could have been busted down in to three "normal" vials. 2 hits and it was like a DMT trip for 10 hours every time. However, it does not take you as far away as DMT does, meaning the "blast off" state, where you are pretty much unconscious for 5 minutes or so until you come to and the after effects fade. At higher doses of LSD, probably somewhere at 1000mcg, it becomes like ketamine. You can completely "bubble out" into space, not like the "hole" on K though, it is much more comfortable, due to the serotonin being released in copious amounts from the presynaptic cell. Ketamine causes some, but not enough to not make the experience dysphoric. Take all 11 hits to anyone thinking about it. Chances are that the L that you get has already touched a lot of hands and been diluted. You won't die, you will feel better and the visuals actually get easier to control as the dose gets higher, due to the fact that your ego dies. So, even small doses of LSD can cause some ego death, the key about the nature of the chemical is, that the more you take, the more your ego will die, and it is verrrrry nice to be without it. It allows you to think and piece together everything, you can talk coherently, perform tasks, anything. If anyone is thinking about it at all. Take more, if you can handle a 250-300mcg trip, you can handle above 500mcg, for sure. You'll thank me.