dntcheckthtbxdoc
Bluelighter
- Joined
- Sep 11, 2010
- Messages
- 193
It seems the more I research the effects of inorganic salts (magnesium sulfate for example), the more I think that they may really be the key to bypassing this controlled-release matrix. I just found an interesting patent online....,
http://www.google.ru/patents?id=oNADAAAAEBAJ&printsec=abstract&zoom=4&source=gbs_overview_r&cad=0#v=onepage&q&f=false
Some highlights are as follows...
"A swellable hydrophillic matrix tablet that delivers drugs in a controlled manner over a long period of time and is easy to manufacture. More specifically, the drug is disposed in a matrix composed of HPMC or polyethylene oxide, in the presence of a salt, which may be a combination of salts. Suitable salts include sodium bicarbonate, sodium chloride, potassium bicarbonate, calcium chloride, sodium bisulfate, sodium sulfite, and magnesium sulfate. Outward diffusion of the drug is controlled by an inwardly progressing hardening reaction between the salt and the dissolution medium, possibly also involving the drug itself."
"The present invention is a new monolithic dosage form that delivers pharmaceutically active agents in a controlled release manner, and that is easy to manufacture. This dosage form, in a form such as a monolithic tablet, may approach zero order delivery of drugs which are either of high or low solubility. This dosage form or tablet is comprised of a hydrophilic swellable matrix, in which is disposed a pharmaceutically active agent and a salt. The salt, either in combination with the drug or another salt upon reaction in an aqueous medium, causes a hardening reaction of the matrix. The rate of outward diffusion is controlled by exposing the product to an aqueous medium. This in turn causes a hardening reaction to occur in a time dependent manner from the outer boundaries towards the inner boundaries of the product; the hardened reaction product, in turn limits outward diffusion of the drug as the inward ingress of aqueous medium causes a progressive hardening from the outer boundaries of the dosage form or tablet in a direction towards the inner core there"
Hopefully this will help others with hands on research...what I'm thinking is that since adding magnesium sulfate(or other inorganic salts) to polyox causes it to precipitate(harden/solidify), it could compact/harden the matrix enough to render it ineffective and eliminate gelling(as in the epsom salt/oven method mentioned a page or two before this) or could be used for salting out the polyox in a mixture of water/powdered OP through filtering. Unfortunately I've yet to be able to try any hands on experiments, and can still only make theorhetical suggestions from what I know about polyox and controlled release matrices.
see snake what do ya think this seems to be what happens to em when i do this epson/oven bake method....have u tried to do it yet?