Incunabula
Bluelighter
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That is proscaline. It's not really rare.
Which "Rare" Psychedelics Do You Want To Try?
- Thread starter love_sex_desire
- Start date
That is proscaline. It's not really rare.
Incunabula
Bluelighter
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Yes 
I think propyloxy is already pushing it, because proscaline reviews rarely sound glowing. It would be interesting to remove the oxygen from the 4-position of escaline or proscaline, to get "mescaline analogs" of 2C-E and 2C-P - just with the 3,4,5-orientation.
I think propyloxy is already pushing it, because proscaline reviews rarely sound glowing. It would be interesting to remove the oxygen from the 4-position of escaline or proscaline, to get "mescaline analogs" of 2C-E and 2C-P - just with the 3,4,5-orientation.
yepyepwoah
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Mxe
Crashing
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You've given this some serious thought!
fractal fountain
Bluelighter
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I've been encouraging them to get 4-ho-mpt too. But really sad news. Customs stole it, so it'll be another synth before that comes out. Hopefully it's around by june. Just got word from them. Really sucks.
And I know a certain seagull themed vendor (defunct) that had 4-ho-mpt, as well as some other rare goodies. Don't think that's the person Kaleida got her's from though. I remember smoking it a couple times, to minimal effect. But I never got around to sampling it before I had 'that collection' stolen.
Sucks about having to wait for more 4-ho-mpt
((wherethewavebroke
Greenlighter
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Wow, this was a fun thread to read through.
I think I'm most excited about 4-HO-MPT, especially since it's so close. 4-HO-MET is my favorite psychedelic so far, but it did always feel a bit lacking.
However, I think there are a bunch of interesting 2C compounds to explore. An unscheduled 2C synth would be very popular for sale in the north american market, as the only clearnet alternative is 2C-B-FLY, which isn't everyone's favorite compound.
My standouts for synthesis would be:
2C-EF
2C-TFM
2C-N
Maybe 2C-CN or 2C-YN
And what about the other FLY compounds? I'd buy 2C-C-FLY or 2C-E-FLY right now.
RU-28306 sounds very interesting, but with almost no experience information to speculate on, it's hard to really be excited. I guess I'll just keeping waiting for a report.
Oh and why not make 2-oxo-PCP while we're at it?
I think I'm most excited about 4-HO-MPT, especially since it's so close. 4-HO-MET is my favorite psychedelic so far, but it did always feel a bit lacking.
However, I think there are a bunch of interesting 2C compounds to explore. An unscheduled 2C synth would be very popular for sale in the north american market, as the only clearnet alternative is 2C-B-FLY, which isn't everyone's favorite compound.
My standouts for synthesis would be:
2C-EF
2C-TFM
2C-N
Maybe 2C-CN or 2C-YN
And what about the other FLY compounds? I'd buy 2C-C-FLY or 2C-E-FLY right now.
RU-28306 sounds very interesting, but with almost no experience information to speculate on, it's hard to really be excited. I guess I'll just keeping waiting for a report.
Oh and why not make 2-oxo-PCP while we're at it?
An overlooked batch of unscheduled 2Cs are the tweetios; compounds where one or both methoxies at the 2 and 5 positions are replaced by ethoxy groups. Searching around, I've never heard of these ever being sold anywhere for the RC market. Not much more difficult to synthesize than 2,5-dimethoxy compounds, and plenty of interesting examples scattered throughout PiHKAL entries.
I bet 2C-B-5EtO would be a winner, and I wish a certain vendor would look into that, instead of making 2C-B-FLY-NBOMe...
I bet 2C-B-5EtO would be a winner, and I wish a certain vendor would look into that, instead of making 2C-B-FLY-NBOMe...
perpetualdawn
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I think 2C-B-FLY-NBOMe happened simply because there is 2C-B-FLY around, and turning base 2C-X's into their NBOMe counterpart seems to be a straightforward path. That's just my speculation, but I think it makes sense.
I agree that the tweetios would be really interesting.
I agree that the tweetios would be really interesting.
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Forgot about the tweetios (funny Shulgin with this names).
It's staggering how many possibilities there are.
Someone mentioned 2C-N above... I know morninggloryseed had a very profound experience on it but it seems that the dose is very high for a 2C-X and that most people haven't gotten much from it. I'd like to see some of the 2C-G series, they're very long-lasting and potent (2C-G-5 has 36-48 hours (!!) which even I will admit is too long, but at the same time the brief descriptions of trials make it sound very pleasant), and I've never seen any of them but would love to try some. Also the 2C-G series is interesting because when turned into their amphetamine counterparts, the amphetamines appear to be shorter acting, which is really unusual (2C-B to DOB, 2C-C to DOC, etc are the exact opposite of that in dramatic fashion).
It's staggering how many possibilities there are.
Someone mentioned 2C-N above... I know morninggloryseed had a very profound experience on it but it seems that the dose is very high for a 2C-X and that most people haven't gotten much from it. I'd like to see some of the 2C-G series, they're very long-lasting and potent (2C-G-5 has 36-48 hours (!!) which even I will admit is too long, but at the same time the brief descriptions of trials make it sound very pleasant), and I've never seen any of them but would love to try some. Also the 2C-G series is interesting because when turned into their amphetamine counterparts, the amphetamines appear to be shorter acting, which is really unusual (2C-B to DOB, 2C-C to DOC, etc are the exact opposite of that in dramatic fashion).
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I'd also love to see some other 2C-X-flys... I would in particular like to see 2C-E-fly as I think 2C-E is the most special of the 2C-Xs and it would be interesting to see what putting the fly on would do.
I also have always been really curious about the 2C-G series. Some of them sound really nice, although all very long-lasting.
I also have always been really curious about the 2C-G series. Some of them sound really nice, although all very long-lasting.
yepyepwoah
Bluelighter
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2c-c/d/e fly I would definatly try.
cj187
Bluelighter
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It's crazy to think about all the possible phenethylamines that haven't been made yet. Fly, dragonfly, butterfly, EtO, methylthio, ethylthio, etc. If you made all the possible combinations of different substitutions at the 2 and 5 position you could have hundreds of new derivatives of each member of the 2C series.
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I know it's pretty mind-boggling the sheer number of possibilities. And some of them are likely total gems. And then you have some psychedelics already known so vastly different in the nature of their effects as to be very different and unique drugs (DiPT comes to mind, instead of visual distortions they're incredibly profound and unique audio distortions). Who knows what there is to find out there?
It's enough to make a drug nerd drool...
It's enough to make a drug nerd drool...
cosmic charlie
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Right now I'm interested in a couple
5-MeO-MET and EPT look promising.
5-MeO-MET and EPT look promising.
Limpet_Chicken
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I LOVED 2C-B-FLY, would be delighted to see more phenethylamine and psychedelic amphetamine flies, butterflies, hemi-flies and dragonflies made.
2C-TFM and DOTFM I'd love to try big time.
Also, 2C-N/DON and 2C-CN/DOCN. Particularly the 2Cs, IIRC 2C-N and 2C-CN are selective for different intracellular signalling cascades. I'd be really interested to see whether they were both psychedelic.
The benzothiophene homolog of DMT, as well as the analog where oxygen replaces the indolic nitrogen.
That ketanserin-nBOMe thing that acts as a (partial) agonist at 5HT2aRs.
I want to explore the alephs.
And there are a trio of related phenethylamines/amphetamines, a quad of them if I can pull off the microscale synthesis of the nitrostyrene and nitropropene, since I only have 5g of the benzaldehyde, but 3-bromo-4-(1,1-difluoromethoxy)-5-methoxyphenethylamine, the corresponding amphetamine, plus 4-difluoromescaline and 4-difluoromethoxy-TMA, after earnarking 2.5g of the benzaldehyde for 3-bromo-4-(1,1-difluoromethoxy)-5-methoxyphenethylamine and the other half of the aldehyde for the nitropropene for the TMA analog. Then in even further scaled down microscale chem, replacement of the bromine atom at the 3 position of the phenyl ring with methoxy, ethylthio as well if I can REALLY fucking squeeze the shite out of that aldehyde,using my best catalyst, and the microwave, or possibly even more efficient, if the reports of using it for plain P2NP are anything to go by, ethanolamine acetate as an ionic liquid base catalyst for the knoevanagel condensation. And replacing the bromo group with sodium methoxide, or NaSMe/NaSEt to give difluoromescaline and 3-ethylthio-4-difluoromescaline.
After reduction of the nitrostyrene and nitropropenes that is. Using gentle reducing agents that won't reduce an aryl halide because the 3-bromo-4-(1,1-difluoromethoxy)-5-methoxybenzaldehyde was VERY hard to come by, and cost just under ?100 for 5g, and I doubt I'll be able to buy more and I'll have to make it myself if I'm ever to get more than the 5g of aldehyde I have.
Think I'll test the 3-bromo-4-difluoromethoxy TMA analog first, due to the higher potency of almost all the psychedelic amphetamines relative to the corresponding phenethylamines. That way I can get a good idea of whether the phenethylamine will be active, or if the amphetamine isn't, then it'll be replacement of the 3-bromo group with methoxide and methyl/ethylthiolate to give difluoromescaline, which is known to be active, and much more potent than mescaline, IIRC active at something like 30mg, in Daniel Trachsel's paper on fluorinated phenethylamines and psychedelic amphetamines he gives strong human activity at either 30 or 60mg. He never made any phenethylamines or amphetamines with an electronegative group in the 3 position. Seems like nobody has. Shulgin didn't even look at that substitution pattern. Trachsel didn't, aside from 3,4,5-tri-trifluoromethoxyphenethylamine or amphetamine (forget which, may have been both) and I haven't read of Nichols looking at any psychedelic amphetamines or phenethylamines with any substituents that pull electron density from the aromatic ring.
Its just a totally neglected area of phenethylamine/amphetamine chemistry. Its just not been done, EWGs in the 3 position have just been totally fucking ignored.
Which to an autistic-as-hell clandestine chemist practically SCREAMS 'MAKE ME! MAKE ME! FOR THE LOVE OF GOD, PLEASE, I'M BEGGING YOU, MAKE ME!'
And hey even if they aren't active with the bromine atom there, can still replace it with alkoxy/alkylthio groups and go for difluoromescaline and 3-alkylthiomescaline and their TMA counterparts. I hope to hell they are active though, as that means there is much much more ground for exploration which hasn't been touched. Fresh, unexplored, virgin territory for the psychedelic knowledge seeker, begging to be tested, poked, prodded and mined for analogues until there isn't so much as a single remaining potential candidate to go for.
And of course, after the initial aldehyde has been used, for at most 4 compounds, more aldehyde will need to be made, if as I hope, its active, and things like the iodinated, chlorinated, fluorinated, nitrated, pentafluorocyanated and the aryl 3-cyanide as well as the 3,4-di-(1,1-difluoromethoxy)-5-methoxy analog, and 3-trifluoromethyl-4-(1,1-difluoromethoxy)-5-methoxy phen/phet pair.
Then....cathinones! or, rather, acid-labile prodrugs, in the form of the pthalimidopropiophenones, given the way primary amine cathinones are unstable as shit, dimerizing into pyrazine derivatives. Beta-keto-2C-B dimerized so fucking fast that the first time I tried to try it, it turned to inactive glorp before I could get the solution drawn up into a syringe to plug it or IM it.
Albeit it was a lovely colour, bright, almost fluorescent purple glorp. So I'm going to have to prepare them as pthalimidopropiophenones to protect the amino nitrogen; so it can't react with the carbonyl group on the beta carbon of the sidechain, and dimerize into a bunch of substituted pyrazine garbage. Even ifs nice looking pretty coloured substituted pyrazine garbage. I can make bright, nicely coloured crystals and amorphous compounds any day of the week if I want to, be they organic dyestuffs or transition metal complexes.
But using very valuable and rare substituted propiophenones to make bright shiny stuff....no thanks. NOT high on my to-do list.
Really want to try DiPT, and compare with DPT and PiPT. As well as the 5-methoxy homologues of each.
Ibogaine
Sapo (a little dubious about this one given its well known as a gutbuster)
2C-TFM and DOTFM I'd love to try big time.
Also, 2C-N/DON and 2C-CN/DOCN. Particularly the 2Cs, IIRC 2C-N and 2C-CN are selective for different intracellular signalling cascades. I'd be really interested to see whether they were both psychedelic.
The benzothiophene homolog of DMT, as well as the analog where oxygen replaces the indolic nitrogen.
That ketanserin-nBOMe thing that acts as a (partial) agonist at 5HT2aRs.
I want to explore the alephs.
And there are a trio of related phenethylamines/amphetamines, a quad of them if I can pull off the microscale synthesis of the nitrostyrene and nitropropene, since I only have 5g of the benzaldehyde, but 3-bromo-4-(1,1-difluoromethoxy)-5-methoxyphenethylamine, the corresponding amphetamine, plus 4-difluoromescaline and 4-difluoromethoxy-TMA, after earnarking 2.5g of the benzaldehyde for 3-bromo-4-(1,1-difluoromethoxy)-5-methoxyphenethylamine and the other half of the aldehyde for the nitropropene for the TMA analog. Then in even further scaled down microscale chem, replacement of the bromine atom at the 3 position of the phenyl ring with methoxy, ethylthio as well if I can REALLY fucking squeeze the shite out of that aldehyde,using my best catalyst, and the microwave, or possibly even more efficient, if the reports of using it for plain P2NP are anything to go by, ethanolamine acetate as an ionic liquid base catalyst for the knoevanagel condensation. And replacing the bromo group with sodium methoxide, or NaSMe/NaSEt to give difluoromescaline and 3-ethylthio-4-difluoromescaline.
After reduction of the nitrostyrene and nitropropenes that is. Using gentle reducing agents that won't reduce an aryl halide because the 3-bromo-4-(1,1-difluoromethoxy)-5-methoxybenzaldehyde was VERY hard to come by, and cost just under ?100 for 5g, and I doubt I'll be able to buy more and I'll have to make it myself if I'm ever to get more than the 5g of aldehyde I have.
Think I'll test the 3-bromo-4-difluoromethoxy TMA analog first, due to the higher potency of almost all the psychedelic amphetamines relative to the corresponding phenethylamines. That way I can get a good idea of whether the phenethylamine will be active, or if the amphetamine isn't, then it'll be replacement of the 3-bromo group with methoxide and methyl/ethylthiolate to give difluoromescaline, which is known to be active, and much more potent than mescaline, IIRC active at something like 30mg, in Daniel Trachsel's paper on fluorinated phenethylamines and psychedelic amphetamines he gives strong human activity at either 30 or 60mg. He never made any phenethylamines or amphetamines with an electronegative group in the 3 position. Seems like nobody has. Shulgin didn't even look at that substitution pattern. Trachsel didn't, aside from 3,4,5-tri-trifluoromethoxyphenethylamine or amphetamine (forget which, may have been both) and I haven't read of Nichols looking at any psychedelic amphetamines or phenethylamines with any substituents that pull electron density from the aromatic ring.
Its just a totally neglected area of phenethylamine/amphetamine chemistry. Its just not been done, EWGs in the 3 position have just been totally fucking ignored.
Which to an autistic-as-hell clandestine chemist practically SCREAMS 'MAKE ME! MAKE ME! FOR THE LOVE OF GOD, PLEASE, I'M BEGGING YOU, MAKE ME!'
And hey even if they aren't active with the bromine atom there, can still replace it with alkoxy/alkylthio groups and go for difluoromescaline and 3-alkylthiomescaline and their TMA counterparts. I hope to hell they are active though, as that means there is much much more ground for exploration which hasn't been touched. Fresh, unexplored, virgin territory for the psychedelic knowledge seeker, begging to be tested, poked, prodded and mined for analogues until there isn't so much as a single remaining potential candidate to go for.
And of course, after the initial aldehyde has been used, for at most 4 compounds, more aldehyde will need to be made, if as I hope, its active, and things like the iodinated, chlorinated, fluorinated, nitrated, pentafluorocyanated and the aryl 3-cyanide as well as the 3,4-di-(1,1-difluoromethoxy)-5-methoxy analog, and 3-trifluoromethyl-4-(1,1-difluoromethoxy)-5-methoxy phen/phet pair.
Then....cathinones! or, rather, acid-labile prodrugs, in the form of the pthalimidopropiophenones, given the way primary amine cathinones are unstable as shit, dimerizing into pyrazine derivatives. Beta-keto-2C-B dimerized so fucking fast that the first time I tried to try it, it turned to inactive glorp before I could get the solution drawn up into a syringe to plug it or IM it.
Albeit it was a lovely colour, bright, almost fluorescent purple glorp. So I'm going to have to prepare them as pthalimidopropiophenones to protect the amino nitrogen; so it can't react with the carbonyl group on the beta carbon of the sidechain, and dimerize into a bunch of substituted pyrazine garbage. Even ifs nice looking pretty coloured substituted pyrazine garbage. I can make bright, nicely coloured crystals and amorphous compounds any day of the week if I want to, be they organic dyestuffs or transition metal complexes.
But using very valuable and rare substituted propiophenones to make bright shiny stuff....no thanks. NOT high on my to-do list.
Really want to try DiPT, and compare with DPT and PiPT. As well as the 5-methoxy homologues of each.
Ibogaine
Sapo (a little dubious about this one given its well known as a gutbuster)