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Heroin Zopiclone bandit VS The NHS V1.0 "I am Smackacus!"

4DQSAR said:
BTW BE OLD is a good tactic. If you are in your 70s, a GP may rightly feel that it's worth the risks of prescribing a medication IF the result is an increase in 'healthy years' as isolation itself poses risks an not just the obvious ones i.e. a person getting very ill and nobody noticing. I mean if a patient ends up housebound, doing nothing and seeing noone, dementia becomes more likely.

It's always about outcomes. I believe John Cooper Clark is on record saying that when he enters his dotage, he will 'get back on the smack' on the basis that someone in their 80s or 90s whose is a performing poet is quite a good candidate for strong analgesics if it means they can continue to perform. But he nailed it concerning dependence-forming drugs:

First it's fun,
Then it's not,
Then it's hell
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Arn't GP's all living in terror of being branded Dr Shipman if they prescribe old people opiates tho?
 
Ismene2 said:
Arn't GP's all living in terror of being branded Dr Shipman if they prescribe old people opiates tho?
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No - use of diamorphine by GPs was more tightly controlled but it wasn't widely used anyway. I seem to recall he was caught BECAUSE so much diamorphine was apparently being prescribed.

I suppose the thing is that it's the only ROA of the only drug used by GPs whose onset is so fast that calling emergency services wasn't likely. Insulin is the only other I can think off off-hand is insulin (as doctors at the end of their tether tend to self-descruct USING insulin so it's not unknown).

As a general guideline, the analgesic ladder means nobody should be prescribed before a pain-clinic assessment and while 'you cannot X-ray pain' isn't a diagnosis, now, before reaching for opioids, doctors will seek alternatives if that just means a referral.
 
BTW CC Kavain, it isn't reversed by flumazil but binds at multiple GABA-A sites, with the α4β2δ site being most significant. That said, a few researchers found selective ligands which sank without a trace. But if 'full spectrum extract' of kratom is legal, why not 'full spectrum kava'? I don't think it possible to confirm if the kavain in said extract IS natural or IS synthetic.


Anyone else noted that etodamate is buried within the structure of flumazil as well as several research benzodiazepines that ARE PAMs. I ASSUME the -F moiety of flumazil could be replaced with a bioisostere and added to the etodamate scaffold. But that ethyl ester is labile although later research replaced it with a bioisostere is longer acting.
 
pubchem.ncbi.nlm.nih.gov

Ethyl 8-chloro-6-phenyl-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate

Ethyl 8-chloro-6-phenyl-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate | C20H16ClN3O2 | CID 14907889 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
pubchem.ncbi.nlm.nih.gov pubchem.ncbi.nlm.nih.gov

example of benzodiazepine WITH etodamate scaffold. You can click on 'substructures' to view all of the related compounds and critically, how that ester may be 'fortified' although I strongly suspect that any derivative is likely to be quite promiscuous. Lest we forget, methaqualone is similarly promiscuous being a PAM at some sites, a NAM at others and a direct superagonist, agonist, partial agonist, silent agonist, inverse agonist and antagonist at others - it's the fact that the EC50 for each activity differs and why at high doses, it produced seizures (and why dimethaqualone is SO dangerous).
 
4DQSAR said:
BTW CC Kavain, it isn't reversed by flumazil but binds at multiple GABA-A sites, with the α4β2δ site being most significant. That said, a few researchers found selective ligands which sank without a trace. But if 'full spectrum extract' of kratom is legal, why not 'full spectrum kava'? I don't think it possible to confirm if the kavain in said extract IS natural or IS synthetic.


Anyone else noted that etodamate is buried within the structure of flumazil as well as several research benzodiazepines that ARE PAMs. I ASSUME the -F moiety of flumazil could be replaced with a bioisostere and added to the etodamate scaffold. But that ethyl ester is labile although later research replaced it with a bioisostere is longer acting.
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I fucking love reading your posts, they take me 20 mins to understand but every time I learn something new.
 

News: March 2025 – Increasing detections of etomidate and analogues on illicit drug markets is becoming a global concern

Portal of the UNODC ICE Programme
www.unodc.org www.unodc.org

Well, a good YEAR behind the curve. But note that all examples are simply different esters (that 'fortification' I mentioned, although less labile bioisosteres are also known).

BUT as yet nobody seems to have gone for say para nitro etodimate or such - these are likely more active and more selective. But any sedative with a duration of crack is quite likely to destroy lives in just the same way crack does. The melting-point of the freebases would likely make them subject to vapourisation so avoiding that 'needle barrier' and indeed possibly offering a novel smuggling pathway (vapes).

I am purely interested in the scaffolds and in what can be infered i.e. to produce hypotheses that can be subject to well designed experimentation to either disprove or lend a weight of evidence towards proof.

Certainly NOT to destory lives. But forewarned is forearmed.
 
I noted para fluoro etodimate was found in a few samples. It's unclear if this is rational design as the paucity of information means it's unclear what if any differences that substitution has but as noted, if an -F works, I would expect other halogens and pseudohalogens would likewise work.

'Space Oil' suggests someone with a flair for PR as 太空油 is also a snappy name.

But etodimate is only used for induction of general anesthesia but NOT to maintain a medically induced coma which may infer it has chronic toxicity issues.

In Europe we have been witness to clinicians abusing propofol which although structurally different, can also be modified to produce a longer-acting sedation rather than lights-out coma.
 
Bleaney said:
Hmm, Dorian, or, Of Herbs and Altars, I've watched a few of her videos. As a fellow Autistic (and a previously heavy fellow poly-) drug user it was inevitable that I would find her.

Initially I was dazzled by her articulacy and story telling skills, and devoured the first few of her videos that I watched.

Unfortunately, it soon became apparent that she has a way of sensationalising and misrepresenting issues, seemingly just in order to gain, seek, and attract more subscribers and views.

I know that is the name of the game on youtube, but someone with the large subscriber and viewer numbers that she has, because she is attracting viewers from the Autistic, ADHD, drug using, Eating disorder affected, and Gothic / alternative communities, either separately and / or combined, she has a significant reach and responsibility to all of these communities. But she remains completely irresponsible, both in her ongoing and repeated and habitual life choices, and her manner of presenting issues, but I suppose at least she's self aware enough to openly admit this

For example, she completely and deliberately misrepresented the issue of Autistic life expectancy being a lot lower than it is for the general population. It's just the same as in Victorian times, when the infant mortality rate was shockingly high, this skewed the overall life expectancy figures way down. It did not mean that most people were dying in their 30s or 40s, just that the huge amount of infant deaths skewed the figures. Similarly with Autism, there is a shockingly high number of young or relatively young Autistic people committing suicide, meaning this affects the average life expectancy figures massively. But it doesn't mean that barely any Autistic person is going to make it to even 60 years old, as she was making out, for shock value throughout most of her video on the subject. Only much later did she go into the nuances a bit more, but she still didn't cover the subject well or properly :roll eyes:

She also bemoaned not getting subscribed ADHD stimulants for her ADHD, whilst openly being on all sorts of other drugs. I mean, wtf did she expect!? The slightest bit of research would have told her that using, or being known to be using, other drugs at the same time is contra-indicated.

She's also extremely prejudiced, patronising, and misinformed about 'working class drug users', blatantly stating that "they" 'wouldn't be able to research or understand details relating to harm reduction and drug use' compared to someone as educated and middle class as her. :mad: It was that ridiculous and stupid statement that really put me off her, big time! I suppose anyone that just waffles away off the top of their heads, and doesn't bother to review or edit things, is going to come out with some shite. And she sure does that!!

And that story about her father 'disowning' her, when he found out she was using opiates on some holiday they went on together, or something like that IIRC, yeah very dramatic, but maybe he was adopting a tough love approach of 'I'll be here for you, when you've got off heroin or methadone.'

I would not rely on her to be a trustworthy and accurate source of any information tbh. She's entertaining for sure, if you like human drama, and she certainly can tell a good story, (she is also a published writer,) but I can now only stand her in very small doses, spread very long times apart :\
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I used to really like her stories especially the millennium gothic ones and appreciated her personal and nuanced storytelling around issues such as substance abuse and eating disorders - both of which I struggle with. But I think some of her newer stuff is fucking reaching.

She's trying to follow trends and uses clickbait and trending topics even though she knows nothing about them. For example,
I suffer from DID and I think her coverage of 'faking DID online' was so extremely ignorant of what the disorder really is and engaging with that stuff at all is really harmful for people with the condition who are trying to recover.

It's like if someone who had never had a drug addiction made a video talking about what someone with a 'real addiction' looks like Vs kids posting pics of xannax ladders on insta for clout. - you just have no idea! and it just gives people suffering from those issues more reason to invalidate themselves, stay in denial and get sicker.

I used to subscribe to her patreaon and actually messaged her about that specifically. I was Very polite but she never responded.
 
Perkins : Reborn said:
Had no idea who this woman was before just searching her.

Looks like the type who'd superficially cut her arms and then phone you to let you know. I've known more than one.
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Definitely, she's totally self-dramatising and attention seeking, although she can grab your attention with the way she puts her stories together. (Until you start to see her pattern emerge.)

Her reach and numbers on YouTube are quite astonishing though. It's probably because she's been clever with her hash tags, and that many different sub-communities might be able to relate to her in some way.

But, as @highabdl said above, I also agree that she's spreading herself too thin. Maybe her core topics that she knows most about might be 'goth culture' and eating disorders. And then the other communities, which she does belong to, but she's very under-researched compared to the folk who specialise in those subjects separately. There's many other neurodivergent content creators for example, who don't have 10% of her subscriber and viewer numbers, but their content is generally so much better researched and thought out for those subjects. Some of her comments about Autism, ADHD, and drug use have been frankly rude and insulting, and she does not 'do her homework' so to speak, in terms of any research at all, for making quality videos. I don't really rate her knowledge of substances and addiction and recovery etc very highly at all, and as to how to work things to her own advantage she's clueless. But there she is with 313,000 subscribers and thousands of views per video.

It's possibly all those goths or ex-goths that are her biggest fans. She does love talking about her role in goth subculture, and would have you believe that she was somehow a central figure in the whole scene. I mean, I can imagine people flocking to her at events, if she turned up all dressed up and made up as she is now, plus she'd probably have been very good looking at the turn of the millennium, when she was in her early 20s or late teens. And if she had her story telling skills back then too. But I'm sure she's exaggerating her own importance.

It's weird who can become a kind of youtube celebrity, and it's definitely not always related to the quality of the videos.
 
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What, someone using social media as an income stream? Whatever next...
 
4DQSAR said:
What, someone using social media as an income stream? Whatever next...
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To be fair, her channel is highly likely de-monetised, given the nature of the subjects she talks about, and how extreme You Tube is with it's demonitisation policies, regarding any remotely controversial topics.

And she does not shy away from controversy, that's for sure! It seems to me that she thrives on it!

I kind of respect her for that, more than anything else. She's probably fucked off the monetisation for the sake of being free to talk about whatever she wishes, without having to use all those lame euphemisms, bleeps, and initialisms etc.
 
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There is more than one way to make money from streaming platforms. Recommening others, recommending products and services and so on. Plus built up subscribers and pivot - that last one is the single most popular way.

If it's free - YOU are the product.
 
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