I consider myself to be fairly knowledgeable about drugs (I have done my research and tried to find the answer to this question), and I asked the same question. How is it possible for someone with no cannabis tolerance to smoke properly (meaning the cannibinoids should be in your blood and brain) and not get high? I'm not saying it's impossible or that anyone here is lying or anything, I'm just saying it makes no scientific sense in terms of any science I'm familiar with. I just don't see why cannibinoids would work normally on your receptors every time you smoke except the first. It would make cannabis the only drug I know of that has that effect, which would be fascinating. You seem to know the answer, so could you (or anyone else here for that matter) explain it or at least put up a link so I can read about it myself?