Ernestrome
Bluelighter
5-HT2 said:I highly doubt that wine significantly potentiates MDMA. However, I could see how champagne would increase the speed of absorption, because it relaxes the pyloric sphincter (the valve between your stomach and intenstine.
Vol. 300, Issue 1, 236-244, January 2002 http://jpet.aspetjournals.org/cgi/content/abstract/300/1/236
3,4-Methylenedioxymethamphetamine (Ecstasy) and Alcohol Interactions in Humans: Psychomotor Performance, Subjective Effects, and Pharmacokinetics
Unit of Pharmacology, Institut Municipal d'Investigació Mèdica (C.H.-L., M.F., P.N.R., E.M., N.P., J.O., J.C., R.T.); Universitat Autònoma de Barcelona (M.F., P.N.R., R.T.); Unit of Psychiatry, Hospital del Mar (M.T.), and Universitat Pompeu Fabra, Barcelona, Spain (J.C.)
3,4-Methylenedioxymethamphetamine (MDMA) is frequently consumed in association with alcohol. The effect of this combination in humans has not been previously investigated. Nine male healthy volunteers received single oral doses of 100 mg of MDMA plus 0.8 g/kg ethanol, 100 mg of MDMA, 0.8 g/kg of ethanol, and placebo in a double blind, double dummy, randomized crossover trial. Measurements included psychomotor performance, subjective effects, and pharmacokinetics. Plasma concentrations of MDMA showed a 13% increase after the use of alcohol, whereas plasma concentrations of alcohol showed a 9 to 15% decrease after MDMA administration. The MDMA-alcohol combination induced longer lasting euphoria and well being than MDMA or alcohol alone. MDMA reversed the subjective sedation induced by alcohol but did not reduce drunkenness feelings. MDMA did not reverse the actions of alcohol on psychomotor abilities. Combined use of MDMA and alcohol causes dissociation between subjective and objective sedation. Subjects may feel euphoric and less sedated and might have the feeling of doing better, but actual performance ability continues to be impaired by the effect of alcohol. Confirmation of these findings in further studies will be highly relevant in terms of road safety.