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  • N&PD Moderators: Skorpio

Will somone draw this plz!

PCP_2D_Structure.JPG
 
Last edited:
johanneschimpo said:
just imagine pcp with a hydroxyl on the 3-position

? right ?
Click to expand...

He's probably wondering where the 3 is.

I would guess its on the phenyl ring
 
I think that usually with this type of structure you start numbering with 1 at the nitrogen, but I'm not sure which way you go after that.
 
Yeah, that could be it, but unfortunately the name 3-OH-PCP is so vague that the hydroxyl could be on any of the rings.
 
^

thanks.

and actually, not the mu effect, more for its supposed 8x greater affinity for the PCP receptor.

If this is true, its dose would be... logically, 8x lower than that of PCP, putting it in the mcg range. Even given its increased analgesic properties (supposedly a magnitude lower than M), the mcg dose would keep the mu effects well away from an ED (or LD for that matter), would it not?
 
Thought it had the same affinity for the PCP receptor - all the SAR studies I've read about the arylcyclohexylamines state that 3-hydroxy, 3-methoxy & 3-amino groups produce a compound of the same potency, but with pronounced opiate effects (possibly making the overall effect seem stronger, especially in animal trials)
 
^

Do you have any ideas on possible additions to the 3-OH-PCP to make it look... less 'PCP'-ish?? Possibly that would further increase its activity @ PCP receptor?

In the rhodium PCP file theres a claim the 3-OH adds '8x affinity' but its reference leads to a deadend 'personal communication' reference.
 
Replace the piperidyl group with an N-ethylamino group; beyond that you run a fair chance of altogether abolishing any noticable NMDA-antagonist activity.

Although that said, you could replace the cyclohexane ring with a cyclohexanone ring to produce the ketamine analogue of PCP (but that would be a much more complex synthesis)
 
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