Will somone draw this plz!

[Sphinx (Afterlife)]

3-OH-PCP

thanks!

 

[Smyth]

 

[Head__Funk]

Picture 404.

 

[johanneschimpo]

just imagine pcp with a hydroxyl on the 3-position

? right ?

 

[bigmac74]

just imagine pcp with a hydroxyl on the 3-position

? right ?

He's probably wondering where the 3 is.

I would guess its on the phenyl ring

 

[Mr TIMO]

there ya go

 

[Morninggloryseed]

 

[DadeMurphy]

I think that usually with this type of structure you start numbering with 1 at the nitrogen, but I'm not sure which way you go after that.

 

[Morninggloryseed]

 

[Ylide]

Yeah, that could be it, but unfortunately the name 3-OH-PCP is so vague that the hydroxyl could be on any of the rings.

 

[Sphinx (Afterlife)]

Yeah, that could be it, but unfortunately the name 3-OH-PCP is so vague that the hydroxyl could be on any of the rings.

its sposed to be the phenyl ring

 

[fastandbulbous]

Here we go then ('cos I'm nice like that!), see the attached jpeg. I assume you're interested in it because of its affinity for the mu opiate receptor?

 

[hugo24]

And should this have a more pronounced opiate effect?

 

[hugo24]

Synchronicity on that thought 8(

 

[fastandbulbous]

And should this have a more pronounced opiate effect?

Yes, more analgesia & supression of respiatory centre (making it more dangerous!)

 

[Sphinx (Afterlife)]

^

thanks.

and actually, not the mu effect, more for its supposed 8x greater affinity for the PCP receptor.

If this is true, its dose would be... logically, 8x lower than that of PCP, putting it in the mcg range. Even given its increased analgesic properties (supposedly a magnitude lower than M), the mcg dose would keep the mu effects well away from an ED (or LD for that matter), would it not?

 

[fastandbulbous]

Thought it had the same affinity for the PCP receptor - all the SAR studies I've read about the arylcyclohexylamines state that 3-hydroxy, 3-methoxy & 3-amino groups produce a compound of the same potency, but with pronounced opiate effects (possibly making the overall effect seem stronger, especially in animal trials)

 

[Pharaoh Sphinx]

^

Do you have any ideas on possible additions to the 3-OH-PCP to make it look... less 'PCP'-ish?? Possibly that would further increase its activity @ PCP receptor?

In the rhodium PCP file theres a claim the 3-OH adds '8x affinity' but its reference leads to a deadend 'personal communication' reference.

 

[fastandbulbous]

Replace the piperidyl group with an N-ethylamino group; beyond that you run a fair chance of altogether abolishing any noticable NMDA-antagonist activity.

Although that said, you could replace the cyclohexane ring with a cyclohexanone ring to produce the ketamine analogue of PCP (but that would be a much more complex synthesis)

 

[deeperSense]

your the daddy!!!over my head nice work!!!