There are so many drugs I have never even tried, and most of my experimentation was back in the eighties.
I don't "hate" weed, per se, but I certainly don't see the joy in it as so many people seem to. I think I have gotten nicely high from it maybe twice; it was when I lived in another state and a friend came down to visit. Another friend always had weed, and we smoked some and got an attack of laughter that basically lasted all day. That was fun! Last summer, when I was withdrawin from my years-long opiate addiction, my room mate would let me hit his pipe a couple times each evening to see if that would help me any, but it really didn't. I don't think it did much, actually, except make me grind my teeth. It does tend to make me anxious and gives that "spacey" feeling. Not a nice buzz for me at all. However, I really like the way it smells! I smoked hash once, and that was kind of a mellow high.
Coke/crack is the only drug I ever purposely walked away from and never looked back on. In a nutshell, I liked it too much. One night, I almost OD'd on it and seriously thought I was going to die; I think I came closer than I'd ever want to know. My heart was pounding so hard I thought it might explode, and my mind was racing with terror and all kinds of crazy thoughts. Since that time, it has wreaked havoc on my family, and I have seen people I love do the most awful, shaming, debasing things to get money for their next hit of the pipe. More than once, my husband and I had to venture into the worst neighborhood ever to rescue my daughter from some or another situation she'd gotten herself into, trying to score crack. She also surrounded herself with some "choice" people. I am not trying to be all high n mighty or preachy, as I am sure lots of people use that (as any drug) responsibly, and I know what I do is no better nor worse. This is merely my experience, my opinion. (She's totally clean for two years now, BTW!)
Before I ever got hooked on pain pills, my DOC was alcohol, mainly beer. Funny thing was, once I started doing the pills with regularity, I lost my taste for alcohol to the point that even smelling it would make me nauseated. Since getting clean-ish, I do drink sometimes, and I enjoy it again, for the most part. However, I hate the hangovers, and I know it does terrible things to one's body. If I have any pills, I don't even think of drinking.
I smoke, but I despise nicotine. A few years ago I quit for a time and was to the point that I didn't really even think about it or crave cigarettes anymore, but stupid me, for some reason I started up again. If I drink alcohol, I have to smoke, and when I take my pain pills, I chain smoke. By the end of this calendar year, I am going to quit for good, before it's too late. Smokers in my family tend to die young, while those who have never smoked or who used to smoke but quit live to ridiculously old ages, and I'd like to be on the latter team.
Drugs I've never tied that scare the crap outta me: PCP, meth, and inhalants. (Is PCP even an issue anymore? It was big back when I was in high school, when dinos walked the earth, lol.)
Drugs I've never tried that sort of pique my curiosity: LSD, MDMA, Shrooms.