Bupropion is really peculiar, you could use a really long name and call it N-tertbutyl-3-Chloromethcathinone, it's identical to 3-CMC but reduced with N-tert-butylamine instead of methylamine. I was so depressed I could barely get out of bed or work so my doctor put me on 100mg a day, which quickly escalated to 300-400 a day. The tolerance build with daily use is no joke. I tapered off with ephedra tea, since it made the norep side of the withdrawals not suck as bad.
Insufflating it can be nice, I get IR 100mg's and I've never needed more than 300mg within a day. Oral administration afaik is just an NRI, insufflated though you can feel the dopaminergic buzz. Bupropion is really unique, especially the way that it potentiates NDRIs and NDRAs like amphetamine and methylphenidate. On its own, it's like a generator of background energy for me but in a very adrenergic way. When I took it daily for months it had me to the point of being kind of a menace to my neighborhood so I started not escalating my dose past 300mg a day after a couple of incidents.
Eventually I developed an arrhythmia that ceased when I stopped taking it daily, but I've had one on and off my whole life that often vanishes for years, returns briefly, then vanishes again.
Bupropion on the first couple days felt like it was going to turn me into a fucking serial killer, and since it lasts longer then 24 hours, dosing the same time every day will lead to your blood plasma levels of Bupropion escalating over time. It had me skateboarding like a fucking maniac, getting hit by cars and walking it off type shit. Got in really good shape while on this, the last time I had abs was my "all I eat is acid, Bupropion, coca tea and fish" phase hahaha.
To the more hedonistic folks out there, don't try to push this one for a rush. It's more subtle than that, but also possesses more power than things like methylphenidate, NEP, methamphetamine or amphetamine when it comes to VERY specifically throwing you into long lasting aggression and mania that you can't recognize, but others can.
A former property manager came over to scold me about letting this unhoused guy sleep on my apartment's porch and she left the conversation sobbing and shaking because I low-key lost my fucking mind on her. Upon walking back into the apartment, the whole gang was just kind of wide eyed staring at me over the shit I'd offered to do to the apartment building (and hers) if she (property manager) wanted to escalate things. I believe Africanized bees, termites and a pocket knife were all involved in the threats. I also really didn't want her to come inside bc there was an active mushroom growing and DMT extraction operation going on inside the apartment.
That same unhoused guy only a few days later went off about the "fucking faggots" in the neighborhood, and literally all six of us living in the apartment at that time are queer. This unhoused man was definitely not named, but claimed to be named Rutherford. Still taking 300mg of Bupropion a day, I had no issue staying up through the night to listen for him to come through the gate door onto the porch, where I ran up on, offering to kick the last few teeth out of his mouth if I ever saw him again. He didn't come back. Only cathinones can keep me up, I'll sleep through meth, speed, coca, etc no problem but Bupropion and NEP keep me up and I can't do shit about it.
When I stopped taking Bupropion, this seemingly bottomless well of homicidal again stopped.
What's funny too is that recently I've been so depressed that I'm really deeply struggling with it, so I've been taking 100mg-250mg every other day, occasionally taking a few weeks off. I get rx'd 300mg a day so it lets me build up a good back stock, I've got ~170g total stored right now. It mixed fine with ephedrine, amphetamine, methylphenidate, MDMA, kanna, and coca tea which I was nervous about at first, but it seems to play nice with them.
Edit: I recently moved and need to rebuild my fume hood, but I'm interested in what potential lies in different phenyl, alpha and N substitutions on this drug. How is it if reduced with N-secbutylamine instead of N-tertbutylamine? What about if the 3-chloro was instead 3,4-dichloro, in the original paper that discovered Bupropion that one had some serotonin transporter activity that looked interesting. Even experimenting with an alpha-ethyl, or 2,5-dimethoxy-4-(alkyl or halogen) phenyl group would likely lead to neat shit imo. The metabolites of Bupropion are very well studied so you can try to infer what they'd look like in modified cases, and given that Radifaxine (vaguely similar to phenmetrazine in structure) is one, I wonder if the 2,5-Dimethoxy-4-Bromo phenyl structure would lead to a metabolite of the known psychedelic phenylmorpholine 2,5-dimethoxy-4-bromophenylmorpholine.
Sorry for being so ranty, I'm on Bupropion right now.
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