Whats ur opinion about the antidepressant wellbutrin ?

[Byzek]

I'm presuming you're in the US? Where I live I can get blood tests for free if there's a good indication.

nah im in germany. i cant go to my doc and say hello i wanna do blood work for specific things they just do normal blood worjk

 

[Byzek]

Strictly in my opinion, antidepressants regardless of their pharmacology are ineffective except for cases of severe depression—like unable to get out of bed or post on a drug forum depression.

lmao.
tbh i have quite the same opinion. for me even depression is not so real but im desperate. its funny coz antidepressant dont work better than placebo which was shown in studies.

 

[bluecollartweeker]

Ive only had use from bupropion as a way to quit smoking for short time perioids, i used to have a proper lab grade set up to isolate and recrystalize bupropion from wellbutrin to snort it when me and my mate were put of speed but it was never as good as real NDRI's because the only dopamine reuptake imhibiting metabolite is the 6th or 7th in the cascade, so most of the dopaminergic activity is contingent on norepemephrines release and the effect is usually overwhelmingly peripheral not central. I used it orally when i was put of ritalin a few times but always had a strong histamine reaction dermally.

 

[Byzek]

IM using methylphenidate since 3 years ofc tolerance is fucked up so i thought ok lets try wellbutrin.
doies this med work immediately or do i have to wait for 2 weeks ?
took one doese of 150mg retard and second dose today the first time.
im not sure if i notice anything at all lmao

 

[Byzek]

Does it also take 2-4 weeks until i feel an effect.
Today is day 3 im not sure if i feel anything.

 

[Pickledlemons]

I have some of that. Was taking it for a while and never noticed any affect. But I was also forgetting to take it a lot. So that may have been the problem.

My previous doctor, the really cool one, the one that admitted the naloxone in suboxone has no purpose for being in there. He told me he thinks anti-depressants... are glorified placebos. Not in those words but, something along those lines.

 

[kongoman]

Ive only had use from bupropion as a way to quit smoking for short time perioids, i used to have a proper lab grade set up to isolate and recrystalize bupropion from wellbutrin to snort it when me and my mate were put of speed but it was never as good as real NDRI's because the only dopamine reuptake imhibiting metabolite is the 6th or 7th in the cascade, so most of the dopaminergic activity is contingent on norepemephrines release and the effect is usually overwhelmingly peripheral not central. I used it orally when i was put of ritalin a few times but always had a strong histamine reaction dermally.

Yeah its a good med to stop smoking. I did it one time with any WD. But now that i take real amphetamines this is bullshit.

 

[Dextro .45]

It is a great antidepressants FAR better than the SSRI's regarding side effects etc

Bupropion (Wellbutrin) features a beta-ketone-amphetamine skeleton structure. Basically a substituted Cathinone with a Phenylethylamine core structure

Classified as a NDRI, it's a mild stimulant predominantly acting via Norepinephrine. It only has negligible Dopamine inhibition (roughly 15-20% DAT inhibition at maximum dose of 450mg

Ritalin (Methylphenidate) on the other hand is fully capable at inhibiting more than 50% of DAT ....even 60-80% at high doses. Ritalin isn't a typical DNRI ....it's an "Inverse Agonist" nearly identical to Cocaine in their MOA ...they release monoamines DAT/NET/SERT similar to the Amphetamines

ED-50 - Effective Dose to inhibit 50% of DAT is required to enduce euphoric/pleasurable subjective effects.

Bupropion (Wellbutrin) 150mg XR and 300mg XR tablets are a decent antidepressant with several off-label uses, ADHD, reverse sexual disfunction caused by SSRI's, enhances libido & sexual desire, a mild general stimulant, and an effective anti smoking aid, as it's a nicotinic receptor antagonist, reducing the pleasure one receives from smoking....and reduces the cravings for cigarettes and minimizes the withdrawal symptoms from smoking cessation

Bupropion does have its place.....just please don't crush up the tables and snort or inject it hoping for some Cocaine hype high.

It's also an anticholinergic drug....impairment of CNS memory function

 

[bluecollartweeker]

Yeah its a good med to stop smoking. I did it one time with any WD. But now that i take real amphetamines this is bullshit.

Nothing beats AD30's and a smooth cig on the first 15 minute break at your small town labour job. Atleast thats what ive been taught by the life ive been made to enact.

 

[kongoman]

Nothing beats AD30's and a smooth cig on the first 15 minute break at your small town labour job. Atleast thats what ive been taught by the life ive been made to enact.

Whats AD30? Adderall?

 

[bluecollartweeker]

Whats AD30? Adderall?

Yes

 

[kongoman]

Yes

We dont have it here. Only metylphenidate. I imagine its very similar to amphetamine sulphate aka speed paste

 

[CentipedeKarma]

Wellbutrin works until it fucking doesn't.

Was on it at 14 y/o temporarily for a massive depressive episode, did nothing except make masturbation last 2 painful hours so I stopped.

When I finally was released from Prozac's 10 year long shackles in late 2022, I decided to give wellbutrin a shot again, as one time, when I was 16, I found my ex-script of wellbutrin from 14 years old and took 600mg XR with a TON of adderall and had a really euphoric experience.

Well I found out I was bipolar (technically schizoaffective but yea bipolar whatever the fuck idgaf) so ANY antidepressant is a no-go.
I restarted wellbutrin @ 20 years old in 2022. I felt GREAT at first, 150mg XR then 300mg in the morning. Upped, energized, etc.

And then it would wear off.
I would crash SO bad i would want to kill myself every fucking day. Everything started pissing me off. I couldn't be around any form of child as they pissed me off SO fucking bad (i'm autistic as is with auditorial sensory issues as is, so wellbutrin made it worse).

i finally went off all forms of antidepressants after 12 or so years of them January 2023 and my mental health took a complete 180. I tried trintellix for less than a week in september 2023 and i completely 180'd again and relapsed into how i acted at fucking 12 years old. Went off of that immediately and got better. Now i only take adderall XR, abilify, and trileptal, and its perfect.

 

[AlphaMethylPhenyl]

I was on Wellbutrin for a few years and it worked great. Then I got off of it, not a good decision for me. Tried it 2-4 more times since then and it never worked, maybe a bit of mild stimulation for the first three days or so. Strange how it made me better at math but worse at rhetoric.

 

[Esperighanto]

Bupropion is really peculiar, you could use a really long name and call it N-tertbutyl-3-Chloromethcathinone, it's identical to 3-CMC but reduced with N-tert-butylamine instead of methylamine. I was so depressed I could barely get out of bed or work so my doctor put me on 100mg a day, which quickly escalated to 300-400 a day. The tolerance build with daily use is no joke. I tapered off with ephedra tea, since it made the norep side of the withdrawals not suck as bad.

Insufflating it can be nice, I get IR 100mg's and I've never needed more than 300mg within a day. Oral administration afaik is just an NRI, insufflated though you can feel the dopaminergic buzz. Bupropion is really unique, especially the way that it potentiates NDRIs and NDRAs like amphetamine and methylphenidate. On its own, it's like a generator of background energy for me but in a very adrenergic way. When I took it daily for months it had me to the point of being kind of a menace to my neighborhood so I started not escalating my dose past 300mg a day after a couple of incidents.

Eventually I developed an arrhythmia that ceased when I stopped taking it daily, but I've had one on and off my whole life that often vanishes for years, returns briefly, then vanishes again.

Bupropion on the first couple days felt like it was going to turn me into a fucking serial killer, and since it lasts longer then 24 hours, dosing the same time every day will lead to your blood plasma levels of Bupropion escalating over time. It had me skateboarding like a fucking maniac, getting hit by cars and walking it off type shit. Got in really good shape while on this, the last time I had abs was my "all I eat is acid, Bupropion, coca tea and fish" phase hahaha.

To the more hedonistic folks out there, don't try to push this one for a rush. It's more subtle than that, but also possesses more power than things like methylphenidate, NEP, methamphetamine or amphetamine when it comes to VERY specifically throwing you into long lasting aggression and mania that you can't recognize, but others can.

A former property manager came over to scold me about letting this unhoused guy sleep on my apartment's porch and she left the conversation sobbing and shaking because I low-key lost my fucking mind on her. Upon walking back into the apartment, the whole gang was just kind of wide eyed staring at me over the shit I'd offered to do to the apartment building (and hers) if she (property manager) wanted to escalate things. I believe Africanized bees, termites and a pocket knife were all involved in the threats. I also really didn't want her to come inside bc there was an active mushroom growing and DMT extraction operation going on inside the apartment.

That same unhoused guy only a few days later went off about the "fucking faggots" in the neighborhood, and literally all six of us living in the apartment at that time are queer. This unhoused man was definitely not named, but claimed to be named Rutherford. Still taking 300mg of Bupropion a day, I had no issue staying up through the night to listen for him to come through the gate door onto the porch, where I ran up on, offering to kick the last few teeth out of his mouth if I ever saw him again. He didn't come back. Only cathinones can keep me up, I'll sleep through meth, speed, coca, etc no problem but Bupropion and NEP keep me up and I can't do shit about it.

When I stopped taking Bupropion, this seemingly bottomless well of homicidal again stopped.

What's funny too is that recently I've been so depressed that I'm really deeply struggling with it, so I've been taking 100mg-250mg every other day, occasionally taking a few weeks off. I get rx'd 300mg a day so it lets me build up a good back stock, I've got ~170g total stored right now. It mixed fine with ephedrine, amphetamine, methylphenidate, MDMA, kanna, and coca tea which I was nervous about at first, but it seems to play nice with them.

Edit: I recently moved and need to rebuild my fume hood, but I'm interested in what potential lies in different phenyl, alpha and N substitutions on this drug. How is it if reduced with N-secbutylamine instead of N-tertbutylamine? What about if the 3-chloro was instead 3,4-dichloro, in the original paper that discovered Bupropion that one had some serotonin transporter activity that looked interesting. Even experimenting with an alpha-ethyl, or 2,5-dimethoxy-4-(alkyl or halogen) phenyl group would likely lead to neat shit imo. The metabolites of Bupropion are very well studied so you can try to infer what they'd look like in modified cases, and given that Radifaxine (vaguely similar to phenmetrazine in structure) is one, I wonder if the 2,5-Dimethoxy-4-Bromo phenyl structure would lead to a metabolite of the known psychedelic phenylmorpholine 2,5-dimethoxy-4-bromophenylmorpholine.

Sorry for being so ranty, I'm on Bupropion right now.

 

[Pastel]

It improves executive function while compressing emotional range, boosting libido, mildly increasing metabolism and most likely affecting sleep in the long run. While pemoline was available, the combination was considered an advanced protocol for treating ADHD. It is a step up from Strattera as a "brain tonic", but neither of them on their own would be fist line agents against a clinical depression. Depending on what ails you, your mileage might vary. It is an old drug, but if you spent time reading patient reports, none of the generics seem to close on brand name Wellbutrin. An old explanation used to be that the original manufacturer of Wellbutrin put the API in a proprietary matrix substrate that enabled the perfect timing for bupropion metabolization that was never discovered by generics manufacturers. Currently, estended-release formulation is recommended, which, depending on the brand may come in the form of two salts: HCl and HBr. According to patient reports, out of the current crop of generics, the Cypla variety seems to be the most energizing, while the least expensive Slate Pharm seems to be largely ineffective. I apologize in advance to the previous poster, but on its own, it is one of the least likely antidepressants to cause hypomania.

 

[Esperighanto]

It improves executive function while compressing emotional range, boosting libido, mildly increasing metabolism and most likely affecting sleep in the long run. While pemoline was available, the combination was considered an advanced protocol for treating ADHD. It is a step up from Strattera as a "brain tonic", but neither of them on their own would be fist line agents against a clinical depression. Depending on what ails you, your mileage might vary. It is an old drug, but if you spent time reading patient reports, none of the generics seem to close on brand name Wellbutrin. An old explanation used to be that the original manufacturer of Wellbutrin put the API in a proprietary matrix substrate that enabled the perfect timing for bupropion metabolization that was never discovered by generics manufacturers. Currently, estended-release formulation is recommended, which, depending on the brand may come in the form of two salts: HCl and HBr. According to patient reports, out of the current crop of generics, the Cypla variety seems to be the most energizing, while the least expensive Slate Pharm seems to be largely ineffective. I apologize in advance to the previous poster, but on its own, it is one of the least likely antidepressants to cause hypomania.

I've never heard anything about the history of that, are there any resources you could point me towards that I could look further into? That sounds fascinating. I recently got an Instagram ad for a diazepam nasal sprayer and it made me feel similarly about thinking "how the hell did they complex this to be effective enough intranasally".

I also personally found brand name Wellbutrin completely unnoticeable up to 450mg a day, but generic Bupropion works perfectly. I'm also missing all but a small fraction of my intestines, and only have a small intestine left, so if the complexing agent used by the brand name takes longer to dissolve or is otherwise affected by my abnormal GI tract, that may explain it. It's also why I can only use IR instead of XR

 

[Pastel]

I've never heard anything about the history of that, are there any resources you could point me towards that I could look further into? That sounds fascinating. I recently got an Instagram ad for a diazepam nasal sprayer and it made me feel similarly about thinking "how the hell did they complex this to be effective enough intranasally".

I also personally found brand name Wellbutrin completely unnoticeable up to 450mg a day, but generic Bupropion works perfectly. I'm also missing all but a small fraction of my intestines, and only have a small intestine left, so if the complexing agent used by the brand name takes longer to dissolve or is otherwise affected by my abnormal GI tract, that may explain it. It's also why I can only use IR instead of XR

The pemoline/bupropion protocol was in limited practice around year 2000 and until pemoline was withdrawn from the market in 2005. It has been so long that you are unlikely to find references to it unless you talk to a psychiatrist who used to prescribe it. Intuitively, it makes sense since pemoline is purported to be a mild dopamine transporter similar to modafinil (the exact mechanism of action in both is poorly understood) and thus enhances NDRI action of bupropion, which by itself is more NRI than NDRI.

 

[Esperighanto]

The pemoline/bupropion protocol was in limited practice around year 2000 and until pemoline was withdrawn from the market in 2005. It has been so long that you are unlikely to find references to it unless you talk to a psychiatrist who used to prescribe it. Intuitively, it makes sense since pemoline is purported to be a mild dopamine transporter similar to modafinil (the exact mechanism of action in both is poorly understood) and thus enhances NDRI action of bupropion, which by itself is more NRI than NDRI.

Oh so pemoline was being coadministered alongside bupropion? I could definitely see that causing trouble.

 

[Pastel]

Oh so pemoline was being coadministered alongside bupropion? I could definitely see that causing trouble.

Anything can cause trouble. In fact, the existence of this forum is a testament that anything active is likely to cause trouble in the hands of irresponsible users, regardless of their educational level or professional training.