I recently just moved back to my hometown from Asheville, NC. Asheville had pretty much any drug your heart could desire, though I suppose heroin and crack were the most prevalent.
I lived in the "hood" of Asheville (which, if you've ever lived in an actually big city is laughably safer than others) for several months, and could literally walk down the street to any number of my neighbors and get the hookup for pills, acid, x, weed, coke, etc... I remember feeling so popular when my friends and their band came to town and it was my responsibility to get them the "hookup" for whatever they wanted...
Anyways, back in the triangle area of North Carolina, I'm not quite sure what the major drug is since I've been out of the scene for a hot minute. Being a major university area, prescription speed is easy to come by(although I just found out there is a HUGE shortage of adderall nationally when trying to pick up my script the other day so smft...); weed is always easy to find. If you know the right people you can probably get ahold of others. I'll post again when I've been living here longer.