Stimulants Wellbutrin For Depression

[Jabberwocky]

Unfortunately, in the last 4 weeks I've averaged 4 hours sleep....
Per week.
Not sure how much longer I can take this.

The temptation is to immediately taper and save the rest for party nights.

How much do you take daily?

 

[Dextro .45]

I had to look up what methylphenidate is, looks like its a controlled med and I wouldnt want to take it. I basically just felt I needed something to keep myself from ...... I think the Wellbutrin is working good enough.

Bupropion has negligible effects on Dopamine and is more of a Norepinephrine action along with others

Methylphenidate (Ritalin) was marketed as an antidepressant in the 1950’s , 3-4X Dopamine release over Norepinephrine.


Brighten the Day…..with Ritalin (Methylphenidate)

Overcome - depression, fatigue, lethargy
Improve - Spirits and performance

….new mild smooth acting antidepressant and stimulant. Chemically unrelated to the Amphetamines. Ritalin brightens outlook and improves vigor. Does not over stimulate and has little to no effects on appetite and BP/HR

 

[Mycophile]

Im thinking the Wellbutrin must be working. Last week i was SAD, constantly dwelling on something that happened 20yrs ago, regretting what I did, wishing to go back in time. It was killing me. So much so that I had to make a Drs appt and ask for the Wellbutrin.

The sadness is much better since starting. The thing from 20yrs ago still pops up in my head but i dont find myself dwelling on it as much, its like my mind quickly switches to what im doing at the moment.

Hey. I just started 150XL Wellbutrin and so far it's just making me jittery and like I cant figure out how much caffeine to drink on it. I always drink too much coffee and tea and now I guess I need to cut back but I don't know how much is ok.

Did you ever have that feeling and if so, did it go away?

But most of all I'm wondering if Kratom still works well for you on your Wellbutrin? Cause I haven't used Kratom since I've started Buproprion but I love Kratom and I've heard some reports of Wellbutrin fucking with its ability to work. So since you are talking about combining the same three things I am (Kratom, Wellbutrin and Caffeine, though I'm also on prozac and Klonopin) I'm interested in knowing.

And when you first started Wellbutrin how long did it take for it to start having its desired effect? I know this is an old thread, so is it still helping you?

 

[4DQSAR]

We are all different.

I've known people who said bupropion (Wellbutin) worked amazingly well and I've known people for whom it offered no relief from depression whatsoever.

I think it worth pointing out that the MOST effective antidepressant (amitriptyline) AKA 'the gold standard' is efficacious in less than half the patients prescribed it. As far as I know even now new antidepressants are measured against amitriptyline... but often in a misleading way i.e. the highest prescribable dose of the newer antidepressants are compared to the lowest dose of amitriptyline generally recognized to be active as an antidepressant.

If people wonder why amitriptyline is now often religated to second-line treatment, the reason is simple toxicity. If someone takes their entire supply of most modern antidepressants, they may become ill and may end up in hospital. But if someone consumes their entire supply of amitriptyline, the outcome is often a fatality.

So while it's fine to comment that a given medication did or didn't work for you, unless you can provide supporting data, don't assert a given antidepressant is or isn't effective in all cases. A cohort of one is of no statistical value.

 

[Dextro .45]

I had to look up what methylphenidate is, looks like its a controlled med and I wouldnt want to take it. I basically just felt I needed something to keep myself from ...... I think the Wellbutrin is working good enough.

I was on both Bupropion 150mg XR and Ritalin (Methylphenidate) 50mg IR

Wellbutrin (Bupropion) 150-300mg XR (450mg max daily) is decent…..although has negligible effects at the DAT and is more effective at the NET. The main issue is its negative impact on CNS Acetylcholine

Acetylcholine “the learning neurotransmitter” is negatively impacted by Bupropion therapy, which impairs cognitive function, impaired word recollection, processing speed, memory processing……speaking and forgetting a work or someone’s name (that you’ve said thousands of times before)

Ritalin (Methylphenidate) is a “Classic Amphetamine” and is 3-4X more effective at inhibiting the DAT than the NET. It’s not your typical DNRI but instead acts as an “Inverse Agonist” an identical MOA to Cocaine. In fact, Methylphenidate and Cocaine actually compete for the same binding sites in the CNS Stratum

Ritalin (Methylphenidate) is the safest dopaminergic stimulant regarding its cardiovascular profile, rarely causing any significant increases in HR & BP. Also, in therapeutic doses, Methylphenidate is fully capable of inducing Euphoria and used as a performance enhancing drug, antidepressant/mood-boosting properties and recreational use/abuse due to it’s identical effects as Cocaine and the Amphetamines alike.

Wellbutrin (Bupropion) 150-300mg XR is an entry level medication….. it has zero recreational value as it inhibits only 23% of dopamine transporters (50% is required to induce euphoria)

Ritalin (Methylphenidate) in normal doses inhibits more than 50% of dopamine transporters and is VERY Euphoric and pleasurable, especially when added in a cocktail and or ethanol

Ritalin + Oxycodone + Valium + Lyrica + Ethanol = Euphoric Bliss

 

[4DQSAR]

I was under the impression that methylphenidate acts in a manner closer to cocaine than to amphetamines by which I mean it doesn't have much VMAT2 affinity but rather acts on the PMAT hence fewer physical side-effects. I believe phenmetrazine and fencamfamine likewise act on the PMAT and all seem to share the same issue - they tend to feed the needle more readily than even the amphetamines.

Everyone is different and evidently at least a minority of people seem to abuse bupropion (née amfebutamone) so one must assume it's pleasurable. After all, it's a cathinone and since everyone is different, a subjective term such as 'euphoria' has no objective meaning.

Don't forget, any crude inhibition values are MEAN values, there will be people at the edges of that bell-curve. Maybe the people who abuse things we find odd are people at the edges of that bell curve?

Why do a small (but quantifiable) number of people given cyclizine medically go on to develop psychological addiction to the stuff? Every time I look there are new case studies but nobody quite knows why.

I personally loathe anything that messes with my dopamine levels. I don't find it at all euphoric. It's the same feeling as the first time someone you know and trust lies to your face and you KNOW it to be a lie. The difference is that it's me lying to me. I just feel annoyed with myself and think that I've just thrown away a finite resource - my own lifespan.

So don't assume that some arbitary value of an arbitary monoamine produces an arbitary response. We are supposed to be a rational species and one oddity is that we are only of the few species who can find joy in 5HT2a agonists. LSD for us eldely but I'm prepared to accept younger BLer prefer more modern options. Similarly selective NMDA antagonists. It seems most users prefer raecemic ketamine (so it's also a DRI) but there certainly is a minority who truly prefer esketamine.

I think it's as WSB noted - all pleasure is relief.

But being sentient, what each of us seeks relief from can differ from individual to individual.

 

[V00n]

I worked with someone years ago that was taking Wellbutrin for quiting smoking and he said it made him angry, we all could tell he was a bit on edge. I forget if he was able to stop smoking, it was so long ago.

I wouldn't blame the Buproprion, nicotine cold turkey can cause that on its own