vitamin interaction with benzos

[laCster]

does vitamin supplements like vit c, b-complex, multi vitamins, ect... increase the effects of benzos like valium, increase the clearance of benzos thereby decreasing the effects, or do they not interact at all??

 

[HCandKROD]

I've never noticed or heard of any interactions. The B vitamins make me nervous and edgy anyway.

 

[laCster]

ok thanks!!

really? b-complex really really helps with my anxiety and depression. they work really well for me....never noticed any edgyness, rather the opposite, maybe a slight relaxation

 

[hatrix]

I doubt they have any effect on benzos. However, having a poor vitamin intake might effect ones mental state and physical state. Being in poor health and doing drugs will probably diminish effects.

 

[laCster]

good point hatrix!! thanks for the insight!

 

[pasha]

One thing to look out for is the inhibition of glutamic acid decarboxylase in vitamin B6 deficiency. A regulation in this vitamin should in theory promote appropriate GABA synthesis.

I don't think any of them would have much of an effect on kinetics of benzodiazepines as neither of them are substrates, inducers, or inhibitors of enzyme CYP.

 

[laCster]

Umm nope. You are wrong chrom. Thanks for trying to help. You were close, but no cigar....

lolol jk..


i appreciate the post! i didnt know that b6 induces glutamate conversion into GABA! good to know