i had a seizure on 250mgs tramadol and 1 shot of vodka, but i have epileptics in my family so idk...
i've taken tramadol multiple times after that (soo fucking stupid but i love opiates of any kind), but out of all my times taking tramadol, i have only drank on it twice. once when i had the seizure, and another time with 100mg + 350mgs lyrica in the morning, and then i had 2-3 beers and smoked weed at night. i was fine; i never push more than 100mgs of tramadol anymore after the incident, and i always try to take a benzo like valium or klonopin which has anti-convulsant properties.
to answer your question, if you plan on taking tramadol often, i would combine a low dose of valium (5-20mgs) or klonopin (.25-1mg) with it. you don't need the alcohol though, trust me...