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  • Trip Reports Moderator: Cheshire_Kat

Tyramine and MAOI soup (report)

bachus

Bluelighter
Joined
Dec 19, 1999
Messages
704
Location
Frederick, MD USA
Summary:

Subject intended to experience Syrian Rue-Mimosa Hostilis.
Subject was well experienced in many other psychedelics.

Subject was unguided and failed to fully research MAOI/Tyramine interaction potential (twit!). Trip was preceded by 12 hour fast, except for 2 large alcoholic coctails containing vermouth (which some sources indicate contains tyramine) ingested between T minus 4:00 to T minus 2:00.

00:00 Syrian Rue, prepared by stewing finely ground seeds (~6 gm) in ascorbic acidifed sweetened water (only) was ingested.

00:20 Subject observed effects that were not previously described on Erowid or other Ayahuasca sites. Subject decided not to continue with this experiment until more was understood and a better mindset was in effect, so MHRB preparation was NOT ingested.

00:45 - 02:45
The following effects were observed:
Nausea (mostly dry heaves, one unsatisfying vomit)
Wakefulness (this was 2:00 a.m.)
OEVs (trails, grainy buzzing, fringes and other presistence of vision distortions).
CEVs (darkish but distinct fractals; rose-windows; 3-D fluoro environments; detailed, realistic, sometimes lucid imagination visualizations of persons and objects known and unknown)
Poor balance, slight staggering
Diminished mental accuity

MAOI/Tyramine interactions that are specified all over the web but subject did NOT observe:
diarrhea, flushing, sweating, pounding chest, dangerous changes in blood pressure,
mild sedation

02:45-ish
Fell asleep and slept normally until usual waking time.

07:00 Baseline

Inference.
Possibly websites that list MAOI/Tyramine interactions hide the somewhat pleasant ones for fear that people will want to do this recreationally and risk severe hypertensive crisis. Strange that there is no mention of nausea.

Conclusions.
Close and diligent study must inform all personal decisions with regard to potentially dangerous experiments! Even if you've "done plenty of shit like this before".

Further study.
Subject is interested to learn if complete dietary preparation avoids these effects.

Take care of yourselves guys.
B
 
bachus said:
Possibly websites that list MAOI/Tyramine interactions hide the somewhat pleasant ones for fear that people will want to do this recreationally and risk severe hypertensive crisis. Strange that there is no mention of nausea.

The pleasant effects you had are normal for harmala. Take enough harmala and you're definately not going to be feeling sober.

Nausea is very common with harmala ingested orally without tyramine.
 
Good for you for not pushing it! The ayahuasca realm is a pretty tricky one, and does need a lot of attention and patience for it.

Syrian Rue ingested quickly is pretty pukey -- you may wish to try a smaller dose ingested more slowly. Doesn't have the same kick, but that can be fine. I'd also suggest starting earlier in the day. If you're going for the transcendent, it's better not to rush things.
 
bachus what you described is what is to be expected from ingestion of Syrian Rue. It is a psychedelic in its own right, with an intense body load and nausea/vomiting.
 
Thanks guys.
I (oops, The Subject) realized it was getting late, another reason for not continuing with the MHRB. I had a programming task that took longer than expected.

FYI, i can't program fer shit on Syrian Rue (big surprise?)

B
 
Are you sure it wasn't the alcohol that was the problem? It was my understanding that alcohol+MAOI was a major no-no.
 
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