Tramadol gets me itchy and feeling nice and warm when I take at least 300mg's but it doesn't really give the euphoria of traditional opiates. I'm pretty opiate-tolerant though and have been on Suboxone for several years so I don't recommend that you take 300mg's at once like I would. The thing I really like about Tramadol is you can take it with Suboxone and when I mix 300-400 mg's of Tramadol with Suboxone I get a nice little itchy high which I wouldn't get from Suboxone alone.