^ You may know this but in case you don't or anyone reading this doesn't:
Tram and cyclobenzaprine (Flexeril) have a drug interaction that further still reduces the seizure threshold.
Not only that but serotonin sydrom is a big risk also. While cyclo's mechanism of action isn't fully know, one school of thought is that it is structurally related to the first-generation tricyclic antidepressants, with SNRI action. Another theory is that the structure is more closely related to cyproheptadine, an antagonist at histamine H1 receptors, muscarinic acetylcholine receptors, and 5-HT2A serotonin receptors.
Tram is my DOC and I'm always looking to add to it but after reading about this combo I tossed out the 90 cyclo's I had laying around - just so I wouldn't be tempted.
Either way, bad news on this one me thinks. Be careful out there!