Promotion of PEA
Dear Fastandbulbous.
I was just coming back here to review your comments/recommendations that I saw when doing research last night. They're gone though.
I mainly comment on PEA/Selegiline for 2 reasons. First and foremost to WARN people about the dangers of it. I noted weird heart sensations when I first started using the combo, and I was at my Parents house. They had an automatic BP cuff, and when I used it I was shocked to see my usually normal BP up to 170 something over 80 or 90 something. It wasn't an equipment problem. It was the combo of Effexor PEA and Selegiline. I took the BP tester home, did research which told me about FXRs effect on BP and PEA/Selegilines effect on BP. I've been experimenting to get a "safe" regimen for over a month now. My current regimen is in the post you commented on.
The other reason I write is because for people who might have similar neurological problems. Like the first commenter on this thread, I'm VERY impressed with the PEA/Selegiline combo even though it's a pain to take things bi-hourly and hourly. I agree with him that it's absolutely incredible.
I used to drink 2-4 beers 2-3 times a week. After I started on the PEA/Selegiline, my desire to do so (well, twice I drank 2) disappeared. I DON"T and haven't, but I used to WANT to smoke a little pot sometimes too, and that desire is gone too.
I'm just content. I was terribly dysphoric, amotivated, depressed, and completely drained daily for almost 2 years after coming off high-dose FXR I'd been on for 5-6 years. This combo has given me my life back.
I'm not "drugged" either. Look at the doses I mentioned. When I started taking the combo, I took 1/2 to a whole 5 mg of Selegiline every 4-5 hours, a whole 37.5 FXR and another 1/2 later in the day. I would also take a whole 250 mg PEA capsule too. I've made drastic reductions in dose that I wouldn't have done if I wanted to be "high" (or if I had a death wish like you alluded to).
I noted your comment about FXR and Selegiline and had been thinking about switching to a pure SSRI. Like I've told other folks elsewhere who are on SNRI's and Wellbutrin or other DN meds, there's a redundancy in combining them that I don't get. Maybe some folks need all the norepinephrine, but I kinda doubt it.
I've also noticed that fluid retention and vasoconstrictive action is still a concern. Trying to come up with a vasodilator and diuretic that will negate those side effects.
I'm NOT just a PEA promoter (PEA promoters I suspect are the ones that'll tell ya not to use it w/Selegiline so they'll sell more). You'll just have to trust me I guess. I rant on Pete Guithers Drug War Rant website, comment on Dr. Bobs Babble website, and try to help others "out there" anywhere I find someone my experiences might help.
Thanks again for your mentioning the FXR/Selegiline combo problems, and the hyperthermia. With warm weather coming I think that may become a greater concern.
I also wanted to comment that your mention of a knowledge of pharmacology is excellent advice for EVERYONE these days. Med Docs hand out SSRI's, SNRI's, Abilify, Wellbutrin etc. like candy. It's not just Psych Docs medicating people anymore. There are effects like I went through from the long-term FXR use that I suspect apply to MANY psych meds - downregulation etc. The very conditions people are being treated for can be made worse by regular and long term use of meds that treat those conditions. I'm not talking about bipolar meds. Just anti-anxiety, depression, ADHD, and schizophrenia meds.
I've studied pharmacology as a layman since I was 15. After reading all the propaganda about pot, that I never experienced when I used it, I decided to do my own research on drugs. I also went through YEARS of treatment for depression and took dozens of meds. I did a LOT of pharma research trying to learn about those meds and other drugs/chems/supplements that might help. A last comment about FXR and I'll end this. After trying ALL the meds, FXR was like a wonder drug. Supposedly the only thing different about it was the Norepinephrine action and Dopamine action at high doses. I wasn't on a high dose then. I suspect that FXR has actions that effect the brains endorphin-related systems. The manufacturer doesn't list any such in it's data, but if it did they'd have a harder time with it. Why the nausea, vomiting, and other opiate withdrawal type symptoms when high doses of it are suddenly stopped? It's structurally similar to Tramadol too.
"Nuff said. Maybe all this will help you trust me now. I understand.
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