• N&PD Moderators: Skorpio | someguyontheinternet

Too much Phenylethylamine (PEA)?

Do you have a link or reference?



I would exercise concerted caution though--people have had hypertensive crises, and you will not know a priori how you will respond.

e bola

All of the phenethylamine stimulants release some noradrenaline. Guess which phenethylamine stimulant 2-PEA is closest to? Of course, d-amphetamine. d-amphetamine happens to be the strongest noradrenaline releaser of the lot.
As such, considering the two structures vary by a single methyl group, you would assume it would release a significant amount of noradrenaline. Rocknroll had posted these figures without reference (the 2-PEA one is the relevant one as to whether or not it is referenced from somewhere)

Equilibrium dissociation constants:

* Phenethylamine: NE: 10.9; DA: 39.5; SE > 10000.
* Amphetamine: NE: 7.07; DA: 24.8; SE: 1765.
* Methamphetamine: NE: 12.3; DA: 24.5; SE: 736.

As you can see, PEA is about the same as amphetamine in exerting norepinephrine and dopamine release. With a specific MAO-B inhibitor selectively potentiating its dopaminergic effects, however, I'd imagine it'd be closer to methamphetamine in comparison. Because of the fact that MAO-A and MAO-B degrade dopamine equally, it would seem that a nonselective MAOI would not alter PEA's equilibrium and it'd retain its normal amphetamine-like balance of releasing efficacy. Though it's true that nonselective MAOIs exacerbate its adrenergic activity to a degree, regardless, PEA should still cause very prominent and noticeable dopaminergic effects.

[name redacted], do you happen to remember where you got these bad boys?
 
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thinking synonomously with dmt/harmaline, would n,n-dimethyl PEA and/or straight tryptamine/maoi be worth considering?

what would smoked n,n-dimethyl-PEA do?

You guys have to admit that could be interesting.
 
Well I tried it again a couple times today..

Since yesterday 4 00 caps seemed to work, I tried 3.. felt nothing at all.

Then just a short while ago I tried 5 00 capsules, but this time right after i downed the caps I put some tobacco in my mouth. Right about 15 minutes later i felt it coming on..

It feels like super clarity, but when typing to people i was making spelling errors for some reason, moving around everything is super fluid just like DMT, my whole body feels kind of numb.. reminds me of numbness I got from 2C-P or a highish dose of 2C-D (haven't noticed numbness with other 2C's). I pinched myself on the arm and barely felt any pain.

Years ago when I was totally obsessed with DMT I was obsessed with trying to find out why only DMT (unlike ..DPT..etc) would have certain unique effects like fluidity.. super focus..etc.. i'm not as obsessed anymore but now that I got the same effect from PEA I wonder.. if DMT and PEA affect the trace amine receptor similarly but DPT or DiPT or AMT etc don't? Probably nobody knows.

It didn't feel that euphoric really.. I got some head tingles and body chills but there's nothing about it that makes me want to keep dosing.. maybe on deprenyl its different.. The effects are kind of interesting and unique though (didn't feel much like amphetamine really).

Its too short lived to be useful - came on after 15 mins orally, lasted a strong 5 minutes, then by 7-8 minutes it was mostly down. Oh yeah, and during the "peak" it felt like my face was flushed or something.. warm etc.

edit/add: Its about 30 mins since the main effects wore off, my head feels "hot" and a little itchy like i took some niacin.. face is red in the mirror.. feels like a niacin flush..

Edit again, WTF? i'm definitely high again... numb.. etc.. i went walking around maybe some is still in my intestines or whatever.. feeling it pretty strong... its not really too pleasant hehe.. too strong.. I think the feeling is more like a low dose of 5-MeO-DMT rather than DMT.
 
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I went to the healthfood store today and picked up some DL-phenylalanine that I saw.

Anybody know if this stuff is decent if you combine it with a MAOI?

On its own im guessing it has zero effect. Probably get you as buzzed as a glass of coca-cola.
 
No not even. As buzzed as a glass of water.

DL-phenylalanine is basically a slow release PEA, though I found it more jittery than PEA straight. Not nearly as euphoric either, but that can't be a surprise.

With N,N-dimethylPEA or even N-MePEA I'd worry about it lasting too long. PEA seems to work well because it has such a short duration and fast metabolic destruction. Those who've combined it with nonselective MAO inhibitors did not have a good time.
 
now that im back on selegiline after a two year break, the thought of trying it with PEA has crossed my mind, i am not worried about addiction as i have a lot of self control and will not hesitate to flush the stuff if i begin to get fiendy. my question is one of neurotoxicity (apart from downregulation etc.) i know a lot of users seem to think they gave themselves brain damage but im at a loss to think how it could happen - there would be no pro-oxidant metabolite and if there was it would be negated by the selegiline, and there seems to be no effect on SE (even less than d-AMP) so the simultaneous DA/SE release route to damage is also impossible...

any thoughts?
 
The main problem with this combo is too short time of duration.... anybody knows how to extend the duration of combo effect ?
 
Ok...

This sounds a lot like mephedrone to me... and similar potential for re-dosing & duration...

Infact I had already order some selegine a week ago to try out..

I was very sad that mephedrone got banned but didnt want to start buying mdma or amphetamine especialy from street dealers, ect...

Not i have found out about this combo i got really happy! but everyone in this thread is saying dont do it :(
like its some secret amazing high thats soo good you are not allowed to do it.

Well all drugs are illegal & dangerouse thats why they are class A and b drugs and illegal!!

so isnt it better to do this combo if you realy would like to experience the euphoria once in a while? if done at a proper dosage & sensibly?

i found this trip report from a guy on a bodybuilding forum right before i found this thread. he took a few gel caps and had a great night. im shure it should be ok to do this once in a while instead of cocaine or meth?

if the effects are only about an hour?? at least thats more than mephedrone effects are.

Anyways isnt there an "reversible" mao-B inhibitor that will only last a few hours???

the selegine is supposed to be "good" for you!!!
are you saying once you try the"combo" that you will just keep taking it forever??

well i could control mephedrone & years ago when i did mdma and tried speed i would have hated to do it all the time! so cant see why couldnt use this combo in moderation :(

G'day. I'll give a bit of a background. I learnt of this combination through another forum and due to me being quite introverted and of a shy type of personality, (although I love being in socialising environments) I really wanted to give it a try.

When I researched selegiline, I was amazed that a prescription only (at least in Oz) from a doctor could have so many advantages to our health (at low doses). Talked to the doc and got a script written out.


I was taking 5mg per day for about 2 weeks before my PEA came in. It was in a powder form and I mixed some in a little bit of water. Didn't notice anything from that. It was a really small amount though. The 'serving size' was supposed to be 100mg which I thought would be buggerall so it really was bugger all. I have read that much higher dosages are needed to get desired effects.

Before going out with friends I half filled 4 size 00 gelatin capsules with the PEA powder. I took the 5mg dose of selegiline and then 20 minutes later took 1 of the PEA capsules.

20-30 minutes later I still felt nothing, so I thought, bugger it, I'll take the remaining 3 to see what that does.

As soon as I swallowed the last 3, I got this really weird feeling in my head. Then my hair and face started to tingle, then the rest of my body started tingling. My eyes lit up and I could NOT stop smiling! I must have looked pretty goofy. I could feel my heart beat in my chest much harder but definatly not faster (or if it was it was neglitiable).

This buzz lasted several hours at least and the 'come down' was slow and not noticeable.


Then I asked my brother if he could try PEA on its own (he does not take MAO inhibitors). I have him half a teaspoon in water (would have been around 3 capsules worth). He felt nothing from it at all.

Went out last night to a party (2 weeks after my first dose and no PEA in between). I thought if I dont try a stupid dose once, it'll bug me forever. So I took 5mg of selegiline. 1 1/2 hours later I took another 5mg of Selegiline. Then 1 hour later I took 3 capsules of PEA with a glass of water.

I probably should have taken more than 1 glass of water taking into account what it could feel like once the capsules dissolved. Wasn't overly bad though.

About 10 minutes later I got the tingles again!! And the goofy smile and beady eyes and strong beating heart. I think my head felt a bit lighter too but was not unstable walking or anything. However for one small time one thing I did notice was that it felt like I had to be concious to breathe. But this was only when I was trying to interpret the effects. When my mind was on other things there was no problem. This particular night was a cocktail party. There felt to be no problem and no less tolerance to alcohol. Infact, I think the PEA kept me from the depressive effects of alcohol because although I had 5-6 cocktails over 4 hours, I remained a happy goofy looking drunk that could still walk reasonably straight. :)

Anyway, I took another 3 of the capsules about 3 hours after the first 3. Added a little kick (some tingles), but topping up seems to be a waste as does not give a kick like the initial dose. (or topping up that soon).

My goofy smile stayed with me for most of the night/early morning though.

I would/will only ever use PEA when going out. I would hate to have that sort of feeling as an everyday, every situation type thing as I fear my highs would be my normals and my normals my lows.

Will never take 10mg ever again though. Certainly noticed the 'dry mouth' side effect and the PEA made it worse I believe (dry mouth got worse soon after the 2nd PEA dose.

Will continue to take selegiline though, but will cut it back to 2.5mg per day and then see what taking that dose every 2nd day will do when trying PEA out. I am a fit healthy 25 year old who really doesn't need to take that much as a maintaince dose. If reduced effect is noticed, i'll just take a 5mg dose on the day I am going to take PEA instead.

There was a few days after the first week of selegiline taking that I had trouble sleeping, but that seems to be fine now. (increased dopamine).

Other supplements I took before hand in conjuction with the selegiline and PEA

500mg Rhodiola Rosea
1 table spoon of maca
1 table spoon of raw organic cocoa nibs/powder
1 serving (equiv to 40g whole plant) Tribulus. (It does not mention % of saponins so probably of low quality). I have since got one that says 70% now that also has longjack and horney goat weed. hmmm :)

I have taken all the above (and more) and had NO mental effect from them.

Given that my brother felt absolutely nothing (and we are identical twins so should probably respond to substances in similar ways). I would say that unless you take a massive dose of PEA to overwhelm the system and dont mind the toxic breakdown of when it is metabolised, it is a waste of money. MAO-B inhibitors like selegiline definatly work and when you do get a rush, it stays for many hours.
CognitiveNutrition
06-16-2007, 12:29 AM
G'day. I'll give a bit of a background. I learnt of this combination through another forum and due to me being quite introverted and of a shy type of personality, (although I love being in socialising environments) I really wanted to give it a try.

When I researched selegiline, I was amazed that a prescription only (at least in Oz) from a doctor could have so many advantages to our health (at low doses). Talked to the doc and got a script written out.


I was taking 5mg per day for about 2 weeks before my PEA came in. It was in a powder form and I mixed some in a little bit of water. Didn't notice anything from that. It was a really small amount though. The 'serving size' was supposed to be 100mg which I thought would be buggerall so it really was bugger all. I have read that much higher dosages are needed to get desired effects.

Before going out with friends I half filled 4 size 00 gelatin capsules with the PEA powder. I took the 5mg dose of selegiline and then 20 minutes later took 1 of the PEA capsules.

20-30 minutes later I still felt nothing, so I thought, bugger it, I'll take the remaining 3 to see what that does.

As soon as I swallowed the last 3, I got this really weird feeling in my head. Then my hair and face started to tingle, then the rest of my body started tingling. My eyes lit up and I could NOT stop smiling! I must have looked pretty goofy. I could feel my heart beat in my chest much harder but definatly not faster (or if it was it was neglitiable).

This buzz lasted several hours at least and the 'come down' was slow and not noticeable.


Then I asked my brother if he could try PEA on its own (he does not take MAO inhibitors). I have him half a teaspoon in water (would have been around 3 capsules worth). He felt nothing from it at all.

Went out last night to a party (2 weeks after my first dose and no PEA in between). I thought if I dont try a stupid dose once, it'll bug me forever. So I took 5mg of selegiline. 1 1/2 hours later I took another 5mg of Selegiline. Then 1 hour later I took 3 capsules of PEA with a glass of water.

I probably should have taken more than 1 glass of water taking into account what it could feel like once the capsules dissolved. Wasn't overly bad though.

About 10 minutes later I got the tingles again!! And the goofy smile and beady eyes and strong beating heart. I think my head felt a bit lighter too but was not unstable walking or anything. However for one small time one thing I did notice was that it felt like I had to be concious to breathe. But this was only when I was trying to interpret the effects. When my mind was on other things there was no problem. This particular night was a cocktail party. There felt to be no problem and no less tolerance to alcohol. Infact, I think the PEA kept me from the depressive effects of alcohol because although I had 5-6 cocktails over 4 hours, I remained a happy goofy looking drunk that could still walk reasonably straight. :)

Anyway, I took another 3 of the capsules about 3 hours after the first 3. Added a little kick (some tingles), but topping up seems to be a waste as does not give a kick like the initial dose. (or topping up that soon).

My goofy smile stayed with me for most of the night/early morning though.

I would/will only ever use PEA when going out. I would hate to have that sort of feeling as an everyday, every situation type thing as I fear my highs would be my normals and my normals my lows.

Will never take 10mg ever again though. Certainly noticed the 'dry mouth' side effect and the PEA made it worse I believe (dry mouth got worse soon after the 2nd PEA dose.

Will continue to take selegiline though, but will cut it back to 2.5mg per day and then see what taking that dose every 2nd day will do when trying PEA out. I am a fit healthy 25 year old who really doesn't need to take that much as a maintaince dose. If reduced effect is noticed, i'll just take a 5mg dose on the day I am going to take PEA instead.

There was a few days after the first week of selegiline taking that I had trouble sleeping, but that seems to be fine now. (increased dopamine).
 
This sounds a lot like mephedrone to me... and similar potential for re-dosing & duration...

Subjectively it's an odd HIGH, personally wouldn't compare it in ANY way. You'd think it would be like amphetamin (which people have shown structural comparisons) but for me it was extremely FUZZY, not really UP UP UP. Could understand how people talk of PEA as the LOVE chemical, if I was feeling some of what I felt with PEA + SELEGILINE for no reason doing other things (I.e sex, cuddling all the other suggested releasers) I could see the logic.

You'd also want to be careful, people took mephedrone on a "night out" etc or in crazy combinations with RC's like MDAI etc. If you're suggesting PEA +selegiline as an alternative you'd need to take in to consideration potential interaction problems with any other sympathomimetics. I personally wouldn't TOUCH MDAI or other AMINE research chems whilst also taking selegiline. NEVER

Not i have found out about this combo i got really happy! but everyone in this thread is saying dont do it :(
like its some secret amazing high thats soo good you are not allowed to do it.

Evolution in action. If it was the next mephedrone do you think people would be rubbishing it? It's no secret gem, it's been known for a good while. Possibly if there was some ultrashort acting REVERSIBLE MAO-B specific blocker, still ?? who knows

Well all drugs are illegal & dangerouse thats why they are class A and b drugs and illegal!!so isnt it better to do this combo if you realy would like to experience the euphoria once in a while? if done at a proper dosage & sensibly?

dont fall in to the classic trap!
illegal = dangerous
legal = safe [there are good few LEGAL drugs out there RIGHT now which are potential devastating/lethal]

Anyways isnt there an "reversible" mao-B inhibitor that will only last a few hours???

selegiline is an IRREVERSIBLE MAO-B. Assume you mean RASAGILINE (T1/2 = 3 hours) but remember IT too is IRREVERSIBLE. I.e takes approx 2 weeks for any enzymes HIT to return back to baseline. It's NOT reversible

the selegine is supposed to be "good" for you!!!
are you saying once you try the"combo" that you will just keep taking it forever??

There are opposing studies on whether selegiline is beneficial in life expectancy (and these are mostly rodent studies!). The REAL human studies were done on patients with parkinsons, nearing the end of life. NO ONE has funded SELEGILINE for healthy adults til death, against PLACEBO for healthy adults til death. People extrapolate their own opinions from various studies.

My personal gut instinct on the chemical is on/off sometimes ok but as a young adult do not want to be taking it anywhere CLOSE to daily dosing. Few times I have taken it postural hypotension, agitation, anxiety became a problem
 
Subjectively it's an odd HIGH, personally wouldn't compare it in ANY way. You'd think it would be like amphetamin (which people have shown structural comparisons) but for me it was extremely FUZZY, not really UP UP UP. Could understand how people talk of PEA as the LOVE chemical, if I was feeling some of what I felt with PEA + SELEGILINE for no reason doing other things (I.e sex, cuddling all the other suggested releasers) I could see the logic.

Dude I hate amphetamine & for me years ago MDMA was way too strong i didnt like it unles dancing!

After a while i wasnt that assed about the up, up, up energy, conversation stimulation from mephedrone when it was legal.

Infact the effects i was looking/hoping for are infact those warm/fuzzy? sl.ightly euphoric huggy/love feelings..

But whatever.. there are very mixed reports all over the place.

I will just have to try it out & find out for myself.

either... i will like it..

or i wont like it. lol.

dont worry i have researched the maoi's i know a lot about them from past experience & use with other things..

anyways i will let you know what i think to it.
 
Also didnt mean the illegal/safely comment the way you took it..

i just was lazy typing..
what i mean is that..

amphetamines arent really that safe & mess with blood pressure too, right? if you use them silly..??? & mdma is toxic to brain if you dont protect against it..

If you have a problem at least the PEA will wear off fast, right? at least if you only have a short acting MAO-B??

Rhodiola Rosea is reversable but MAOI-A+B
caapi (harmine/harmaline) is reversable too but only MAOI-A
Selegiline yeah MAOI-B but longer acting..... irreversible

i hear coffee kinda works weak MAOI
mabe tobacco smoking helps as its MAOI

Or mabe just try PEA alone higher dosage?
I mean even if 20/30 minute effect its still as short acting as mephedrone & infact i didnt find mephedrone THAT stimulating except for talking.. deffo didnt make me want to explode onto the dancefloor.
Thats why i liked mephedrone when it was legal cause it didnt last too long if you needed to not be high later on.. & also it wasnt too stimulating as to be too much for me... where as speed & MDMA when i was younger had me all over the place like i was a jack-in-the-box with wheels! lol.

I read one one forum a guy said PEA was better at being mephedrone than mephedrone.. but thats only 1 users report.

As for blood pressure... i read minoxidil or no-xplode are both supplements that are vaso-dilating & oxigenate the blood if you need to reverse the effects of PEA or meph.

Anyways whatever.
dont profess to be anyone who even though of looking for alternatives to meph till it was banned.. and at that only used it a month before it got banned.... cause really wasnt that interested in stimulants to even think of looking for them till now...

My knowledge is more DMT & ayahuasca & mushrooms in the past. so forgive my nooby research :D
 
I've researched, and immersed myself into both Phenylethylamine research and use. Yes, it has a huge potential for addiction. However, I think that personally I'm a very rare example of someone who, in fact, did become addicted to it - through my own abuse. I had to address this and learn how to come off and recover successfully. But this is exclusive to me. Caffeine, nicotine, alcohol, etc. have abuse potential - and most not on par or even close to PEA. However, for me with deprenyl, anti-depressants and anti-anxiety medications - that were prescribed, the wicked combo of all these led me into a spiral that was stronger than any legal or illegal drug or drug cocktail I've experimented with. As I've stated before in these here forums I would, in fact, consider myself to be in the post-stages of phenylethylamine addiction. Please, though, consider my circumstances and the supplementary medications that augmented, enhanced, and, ultimately created this situation. IT IS NOT typical.

I have written an article on Phenylethylamine and its implications of use. I am in the works on a follow up article. http://www.mindandmuscle.net/articles/tom-rayhawk/pea
 
I was interested in this idea and have been trying out Selegiline and PEA for 3 days now. I don't see what all the fuss is about personally. It definitely shows efficacy as an antidepressant but even a small amount of alcohol made my face turn into a tomato. I really recommend against combining alcohol and PEA (even without Selegiline a high dose did this).

BP also gets surprisingly high even though I've only been taking 5mg each morning. The highest BP reading I got was 163/111 with 77 HR. That's dangerously high.

I caution against casual use of this combo. I've taken a lot of precautions and still feel that it's dangerous. The extremely short duration is prolific and I have got through a stupid amount of PEA in a matter of days.

For the record, an hour after last reading BP is now 120/83 and HR is 127. This has very erratic effects on the cardiovascular system. I consider myself healthy so I dread to think what effects this has on those less fortunate.
 
I was interested in this idea and have been trying out Selegiline and PEA for 3 days now. I don't see what all the fuss is about personally. It definitely shows efficacy as an antidepressant but even a small amount of alcohol made my face turn into a tomato. I really recommend against combining alcohol and PEA (even without Selegiline a high dose did this).

BP also gets surprisingly high even though I've only been taking 5mg each morning. The highest BP reading I got was 163/111 with 77 HR. That's dangerously high.

I caution against casual use of this combo. I've taken a lot of precautions and still feel that it's dangerous. The extremely short duration is prolific and I have got through a stupid amount of PEA in a matter of days.

For the record, an hour after last reading BP is now 120/83 and HR is 127. This has very erratic effects on the cardiovascular system. I consider myself healthy so I dread to think what effects this has on those less fortunate.
Be aware that selegiline's effect on MAO-B levels is cumulative and takes several weeks to build up. As you reach near-full MAO-B inhibition (after one or two weeks at 10 mg/day), you'll find you'll be able to use far smaller amounts of PEA and they will last much longer, and the resulting lower, more constant level of PEA in your system will limit the cardiovascular consequences.
As you still have significant amounts of active MAO-B in your system, you still need a relatively large amount of PEA to get past the MAO-B in your gut, following which your PEA blood level spikes and then drops off rapidly. At near-full MAO-B inhibition, the pharmacokinetics of PEA become closer to those of amphetamine, with a peak at about 40-60 minutes, total duration of up to several hours and a lower, more stable heart rate and blood pressure throughout.

Having said that, I have experienced the psychological addiction and build-up of tolerance to this combo, and I can't recommend it. It can feel really great, and its boredom-alleviating properties are quite astounding and can be a godsend, but after a few months it becomes decidedly less great, especially euphoria-wise, and in the long term I feel it's had a negative effect on my life.
 
I've been taking the PEA, Deprenyl combo for some time now and what began as an innocent thing turned into addicition where I'd redose the PEA, take capsules to work and split them up to get through the day. It's very easy to OD on this but fortunatelly Xanax 0.25 takes care of it rather quickly. I also pop 400 mg of Magnesium Citrate when I get this horrible headache.

I use it mainly to alleviate boredom, which is daily, but will stop once I begin working again in October.
 
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