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  • BDD Moderators: Keif’ Richards

Benzos Timing

vision conquest said:
A quick look at wikipedia says cimetidine is fully absorbed in around 45 min but can take up to 2hr.
For the enzyme inhibition to have full effect you would want your cimetidine to be well absorbed so waiting a bit longer than 20min would be optimal.

However as long as you give the cimetidine a headstart it would continue to inhibit the enzymes, I just think if you wait for it to be more fully absorbed you would get abetter inhibition.
I was recently prescribed fluconazole which is also a strong inhibitor of the same enzymes and I thought I would experiment with my diazepam.

I took the fluconazole about 30min before taking 20mg of diazepam and after about an hour I was nodding pretty hard which 20mg of diazepam would normally not do for me.
I am also on methadone though which also is affected by inhibition of those same enzymes so probably it was a double wammy.
Click to expand...
So wait 45 minutes before taking benzi
 
Off topic.

I used to cane benzos years ago doses up to 20mg and sometimes 22 25mg.

They made me anxious free I could to anyone I was flying....now they just make me depressed 😔 ☹️ not talkative....blunt....

I don't know what I'm askin

Why is this i spose?

Have I damaged my gaba receptors?

That's the same with every drug i guess
 
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Pirrracetamol said:
What about 2 hours.
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Well I would think that would be about perfect.

You just need to know, how long it takes for your inhibitor to be fully, or at least mostly absorbed.

Then know how long that particular inhibitor is active in your body and then don't over think it.

About two hours seems like it would be pretty much on the money.
 
Pirrracetamol said:
Off topic.

I used to cane benzos years ago doses up to 20mg and sometimes 22 25mg.

They made me anxious free I could to anyone I was flying....now they just make me depressed 😔 ☹️ not talkative....blunt....

I don't know what I'm askin

Why is this i spose?

Have I damaged my gaba receptors?

That's the same with every drug i guess
Click to expand...
Yeh I have noticed a similar thing man and as you said it's pretty much the same with every substance.

The best way to get a good effect again from any substance after substantial tolerence has built up is to take a good long break from that substance and even then tolerence comes back way faster than it originally took to build up in the first place.
 
Pirrracetamol said:
Have I damaged my gaba receptors?
Click to expand...

with a break they should recover, I've been looking at this myself recently

If you do take a break you might need to consider a taper and alternates depending on why you're presecribed them.

Thanks for the reminder and prompt on cimetidine have just ordered some, I've been playing around with Nootrpics as well to help potentiate benzos with a bit of success, but by far the best thing I've tried is pregabalin with them, 300mg with 10mg of Diazepam is amazing, equal to 50-60mg of Diazepam for me as someone with no benzo tolerance.

I'm on a GABA break, but when I return my plan is to try lighter dose pregabalin with diazepam and then experiment potentiators, including cimetidine and then some of the following nootrpics

Pasted-image.png
 
vision conquest said:
Well I would think that would be about perfect.

You just need to know, how long it takes for your inhibitor to be fully, or at least mostly absorbed.

Then know how long that particular inhibitor is active in your body and then don't over think it.

About two hours seems like it would be pretty much on the money.
Click to expand...
Tried roughly 2 hours didn't notice any difference. Think ill just stick with 45
 
vision conquest said:
A quick look at wikipedia says cimetidine is fully absorbed in around 45 min but can take up to 2hr.
For the enzyme inhibition to have full effect you would want your cimetidine to be well absorbed so waiting a bit longer than 20min would be optimal.

However as long as you give the cimetidine a headstart it would continue to inhibit the enzymes, I just think if you wait for it to be more fully absorbed you would get abetter inhibition.
I was recently prescribed fluconazole which is also a strong inhibitor of the same enzymes and I thought I would experiment with my diazepam.

I took the fluconazole about 30min before taking 20mg of diazepam and after about an hour I was nodding pretty hard which 20mg of diazepam would normally not do for me.
I am also on methadone though which also is affected by inhibition of those same enzymes so probably it was a double wammy.
Click to expand...
Can you please post the Wikipedia page of cimetidine?
 
@placebonaut...unfortunately I cannot read the pic you posted listing the various nootropics you are considering as I am totally blind and use a screen reader to navigate the net and it doesn't always give me all the info on a page...

I have tried L-theanine, magnesium glycinate and back when it was still around, phenibut, none of which made any real difference.
I will definitely agree though, that pregabalin can make a difference, however sometimes I get what would certainly be described as potentiation, and sometimes it seems to actually take away from the benzo feeling of total relaxation that I desire.

I think it has to be dosed correctly for a given persons body weight and tolerance to pregabalin.
 
Pirrracetamol said:
I must of missed it somewhere cos it says onset of duration 30 minutes
Click to expand...
You must be referring to the quote near the begining of the pharmacokinetics section.

It actually says...cimetadine is rapidly absorbed and it's onset of action is approximately 30 min with peak plasma levels reached in 1-3 hours.
So it's saying it will start working within 30 min but will take a bit longer to reach peak levels.

There's no need to overthink this...as long as you wait about 45 min after taking your cimetadine your golden.

I do think however that getting more out of your clonazepam in this manor is a bit of a dead end street.

What's really needed is a tolerence break....definitely not judging...just saying.
 
vision conquest said:
@placebonaut...unfortunately I cannot read the pic you posted listing the various nootropics you are considering as I am totally blind and use a screen reader to navigate the net and it doesn't always give me all the info on a page...

I have tried L-theanine, magnesium glycinate and back when it was still around, phenibut, none of which made any real difference.
I will definitely agree though, that pregabalin can make a difference, however sometimes I get what would certainly be described as potentiation, and sometimes it seems to actually take away from the benzo feeling of total relaxation that I desire.

I think it has to be dosed correctly for a given persons body weight and tolerance to pregabalin.
Click to expand...

Here you go, hopefully useful for you this way, there's 3 lists that are all related to each other, 1st the substance, then 2nd effect of the substance in the same order, and 3rd the risk in the same order

Substance
  1. Valerian root
  2. Magnolia bark / Honokiol
  3. Phenibut
  4. Passionflower
  5. Ashwagandha
  6. CBD
  7. L‑theanine
  8. Taurine
  9. Magnesium (glycinate/threonate)
  10. Chamomile
Effect With Benzodiazepines
  1. ↑ Sedation
  2. ↑ Sedation
  3. High CNS depression
  4. ↑ Sedation
  5. Mild calming
  6. ↑ Sedation; metabolic interactions
  7. Mild calming
  8. Mild calming
  9. Mild calming
  10. Mild sedation
Risks
  1. Additive CNS depression
  2. Stronger sedation; limited data
  3. Dependence, withdrawal, blackout risk
  4. Additive CNS effects
  5. GI upset, thyroid effects
  6. Drug‑metabolism interactions possible
  7. Generally low risk
  8. Limited data; theoretical additive effects
  9. Low risk; can cause GI upset
  10. Additive sedation
 
vision conquest said:
You must be referring to the quote near the begining of the pharmacokinetics section.

It actually says...cimetadine is rapidly absorbed and it's onset of action is approximately 30 min with peak plasma levels reached in 1-3 hours.
So it's saying it will start working within 30 min but will take a bit longer to reach peak levels.

There's no need to overthink this...as long as you wait about 45 min after taking your cimetadine your golden.

I do think however that getting more out of your clonazepam in this manor is a bit of a dead end street.

What's really needed is a tolerence break....definitely not judging...just saying.
Click to expand...
I see. Yes I do need a break 😩 how im gonna do it is hard.
 
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