Yeah DiPT is a research chemical for sure, however in my experience with it, for me, it seems extremely benign. And it's also a wonderful entheogen, if perhaps a very different sort of entheogen than anything else I've ever tried. Sinicuichi wasn't entheogenic at all for me.
People make the jump I suppose in the same way that people make any jump. You read a bunch of peoples' experiences and decide that it sounds worth trying. Most of the RC psychedelics I've tried have been worth trying, some I never tried again, but a few have become some of my favorites. LSD was a "research chemical" at some point too. And plenty of plants can be very dangerous, even lethal. I had a worse experience on sinicuichi than I have on any single RC I have tried, and I've tried a LOT of them. It's a gradual process. I respect if someone is unwilling to go there, for sure, but for me, I make informed decisions and I am someone who is very curious and enthusiastic about psychedelics. There are definitely some I don't wish to ever mess with (for example, the NBOMes). But when it comes to Shulgin's creations, I am mostly willing to experiment.
Yeah, I wouldn't be surprised if some day I try some RCs but I also won't be surprised if I never do.
I want to, it's just a matter of being unsure about their safety.