^
this list should keep you busy for a while...
Blood+ - story about an amnesiac girl adopted by a nice family, turns out she's a monster destined to fight monsters like her to protect humanity, family gets dragged into the epic struggle, a nice 50-ep epic with a legit soundtrack by Mark Mancina
C: The Money of Soul and Possibility Control - I'm throwing this in because nobody ever talks about it but it's an awesome series with an amazing premise. A college-aged kid makes a Faustian bargain with an entity known as Midas who promises riches to those that compete and win in an alternate reality known as the Financial District. The catch is that Midas demands your future as collateral, and if your balance reaches zero, your future disappears as the preconditions are suddenly erased from reality. And that's just where the rabbit hole begins.
Shiki - horror series about vampires who take over a sleepy village in the Japanese countryside, has great atmosphere and nice tension
Durarara!! - focuses on a headless Dullahan looking for her head while doing shady jobs to get by in Tokyo where she crosses paths with some other interesting characters, each with stories of their own.
Gungrave - Noir-like gangster epic where most of the characters literally become monsters. Not really sure why it reminds me of Trigun, but it is what it is
Full Metal Alchemist - story about two brothers who try to resurrect their dead mother through alchemy, sets them on a path of discovery that lasts 50 eps. The original story has a bleak ending that ties into a feature film where the brothers live on in parallel-universe Nazi Germany. But wait, there's more. The original series was remade under the title of Brotherhood. It diverges early on and becomes a whole new story invoking new characters and events. I would recommend seeing the original first and if you enjoy it, watch the first film (the remake also gets a sequel film but it's not worth mentioning), and then watch Brotherhood. 100+ eps in total
FYI, Guilty Crown does not redeem itself at the end.