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RCs The Methiopropamine N-methyl-1-(thiophen-2-yl)propan-2-amine (MPA) Megathread V2

I think I've developed quite an addiction for this. Been using it nearly everyday for the past two months. When not taking it my mood isn't affected, but it's so hard getting up in the morning without it. I wonder if it could cause long term fatigue like Meth does. In all my doses i have always taken it orally about 130mg a day.
 
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I think I've developed quite an addiction for this. Been using it nearly everyday for the past two months. When not taking it my mood isn't affected, but it's so hard getting up in the morning without it. I wonder if it could cause long term fatigue like Meth does. In all my doses i have always taken it orally about 130mg a day.


yes you have a problem mate :)
 
I wonder if cross tolerance plays a part in this, i did the usual unfamiliar RC thing with this EPH- small test to make sure nothing untoward happened and it didn't so i tried a greater amount insufflated and then a few days later a fairly substantial IV dose of EPH dissolved in propylene glycol and water, it refused to dissolve otherwise but maybe I'm just impatient and anti stirring and still very few big effects.

A bit of stim jitteriness in my stomach (kinda like feeling nervous? i'm sure you know what i mean) and a bit of vasoconstriction but no rush or euphoria or even any desire to do anything. I mostly just feel a bit sick and a pretty annoying rise in body temperature.

Whether the lack of euphoria was to do with pretty heavy AMT session that I endured this weekend, i say endured because hallucinogens do not agree with my brain and thus i'm still rebuilding any of the monoamines i used up over the weekend or not but either way I prefer MPA over EPH unless i'm missing some sort of game changing ROA for EPH
I don't think you're missing anything or doing anything wrong, I think it might just be that my hypothesis about MPA/EPH holds very nicely (for unknown reasons).

EPH is, like its methyl counterpart, a dopamine and noradrenaline reuptake inhibitor, whereas MPA is (to the best of our knowledge) a releasing agent of the same. Although they both have effectively the same result (increase in levels of those monoamines), it could be that this difference in mechanism combined with individual differences causes the drastically contrasting and polarising reactions in people. The fact that MPA most likely also acts as an MAOI will make a difference as well.

That's my theory on the matter anyway! :)
 
I think I've developed quite an addiction for this. Been using it nearly everyday for the past two months. When not taking it my mood isn't affected, but it's so hard getting up in the morning without it. I wonder if it could cause long term fatigue like Meth does. In all my doses i have always taken it orally about 130mg a day.
Preaching to the choir, mate! I know exactly what you mean. I do about the same amount (come down from closer to 500mg a day though) and I'm managing to taper off very slowly. The trick to remaining functional while giving up is to make it a slightly longer term aim. When I tried to stop doing it straight off the bat after months of abuse, I couldn't get out of bed. It did affect my mood as well but, more than anything, it was just the epic, stupefying laziness which got me. At the moment I take the absolute bare minimum I can get away with and still meet all the demands placed on me. The uni I'm studying at for my masters is in the QS World Rankings top 10 and the pace is furious so I couldn't afford not to use a maintenance dose really (probably the same for all of us).

Fortunately as soon as this year at uni is over, I'll be given the gift of an opportunity to detox completely. If I don't get out of bed for a while, who gives a fuck? It's the summer holidays! Sorry to go off-topic and talk about my problem but I'm just very happy about the chance to properly get off this stuff!

You're right though, the fatigue is a significant problem.
 
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EPH is, like its methyl counterpart, a dopamine and noradrenaline reuptake inhibitor, whereas MPA is (to the best of our knowledge) a releasing agent of the same.

I don't know very much about brain chemistry, but if that's true, isn't MPA much more likely to cause damage in the long term? Please correct me if i'm wrong. But i always was under the impression that releasing agents carry more risks than reuptake inhibitors.
 
I don't know very much about brain chemistry, but if that's true, isn't MPA much more likely to cause damage in the long term? Please correct me if i'm wrong. But i always was under the impression that releasing agents carry more risks than reuptake inhibitors.
I don't actually know, mate. I've always thought of reuptake inhibition as being a gentler mechanism though, maybe you're right.
 
I didn't say anything about MPA causing heart valve damage via 5-ht2b agonism. So no, it's not important. I think you didn't read half the words in my sentences, therefore jumbling everything up and completely losing the point.

You seem like a very smart guy, but you obviously didn't read my post(s) correctly for whatever reason. The only thing I was trying to tell people in this thread is that MPA is probably cardiotoxic, and that people shouldn't try to ignore the cardiotoxicity by using other chemicals with it. If you like MPA enough to not care, that's you. I was advising differently, that's me.

Just some friendly advice, read what you're replying to before you type 10 paragraphs in a reply to it. But hey, I know stimulants can cause this kind of behavior, so maybe you should lighten up on the MPA?
I actually agree with a lot of the things you say, especially insofar as taking another drug to cover up the negative effects of the first is irrational and foolish, but the way you're currently expressing yourself provokes negative responses. I don't know you, of course, but, from what I can tell, your heart seems to be in the right place (why else would you be here issuing strongly-worded HR warnings?)

The thing is, though, that your posts are coming across as judgemental and antagonising. If you think something's a bad idea, explain why first. Stick to simple facts and explanation (and clearly marked conjecture, whenever necessary) then give people a chance to absorb the information before telling them that what they're doing is silly. People are so much more likely to take you seriously if they think you're like them and you're on their side (which, judging by some of your posts, you are -- albeit maybe begrudgingly).

DO NOT SMOKE THIS STUFF

It'll produce toxic sulphur oxides when burnt and you'll die if you do it enough.

Edit: once again, I don't have any actual evidence for that claim but sulphur dioxide is definitely toxic and burning this stuff produces it. I've also heard stories of people getting pretty fucked up from vaping this shit.
Even when I want to give very strongly-worded advice, I still prefer to stay away from actually judging the action. I prefer to let people infer their own judgements from the facts. I mean, if I had gone on to say "it's stupid to smoke MPA", what would I really have added to my post? The honest threat of the consequences means far more to people than any judgement you or I could impose on them.

Keep being honest and not sugar-coating anything but always favour facts and explanations over judgement and opinion. I'm sure you understand the drug use mentality so speak from experience and use your understanding to be a bit softer on people who don't know as much as you.

Anyway, feel free to throw it back in my face now!
 
Leave MPA alone!!!! It's just trying to help you focus on boring tasks while appearing sober to other individuals. People who are after some sort of rush are looking for the wrong RC. This is a pure CLEAN, FUNCTIONAL stimulant.
 
mm a 50mg+ bomb is good for me now, it's something nice and clean
vaporized, don't think i'll do again as it works for what it is orally

i have the feel to chase the high (rush) of it but i don't and doubt you can,
leads to salvia/dalt mixed nice. this has been fun for tripping
 
I actually agree with a lot of the things you say, especially insofar as taking another drug to cover up the negative effects of the first is irrational and foolish, but the way you're currently expressing yourself provokes negative responses. I don't know you, of course, but, from what I can tell, your heart seems to be in the right place (why else would you be here issuing strongly-worded HR warnings?)

The thing is, though, that your posts are coming across as judgemental and antagonising. If you think something's a bad idea, explain why first. Stick to simple facts and explanation (and clearly marked conjecture, whenever necessary) then give people a chance to absorb the information before telling them that what they're doing is silly. People are so much more likely to take you seriously if they think you're like them and you're on their side (which, judging by some of your posts, you are -- albeit maybe begrudgingly).


Even when I want to give very strongly-worded advice, I still prefer to stay away from actually judging the action. I prefer to let people infer their own judgements from the facts. I mean, if I had gone on to say "it's stupid to smoke MPA", what would I really have added to my post? The honest threat of the consequences means far more to people than any judgement you or I could impose on them.

Keep being honest and not sugar-coating anything but always favour facts and explanations over judgement and opinion. I'm sure you understand the drug use mentality so speak from experience and use your understanding to be a bit softer on people who don't know as much as you.

Anyway, feel free to throw it back in my face now!

Haha, usually I agree with you... Well I'll put it this way. SamuelG ticked me off. I was a bit hostile before that, too, but I think I just got ticked off seeing so many people recommend alcohol to "remove bad side effects"
 
Haha, usually I agree with you... Well I'll put it this way. SamuelG ticked me off. I was a bit hostile before that, too, but I think I just got ticked off seeing so many people recommend alcohol to "remove bad side effects"
He's seems like a good guy, I don't think he was trying to be a dick. He probably just misread you, like I did initially, and felt you were being too heavy-handed.

I've been advising people not to drink on MPA as well. We think that thiopropamine is probably an MAOI so there's always the outside chance of dropping dead on a heavy night out if you're not watching your tyramine intake. Nothing in the short or long-term suggests it's a good idea.
 
Having a very lazy day without MPA, I put the rest of my 10g bag out of sight and out of mind. It's not as bad as it used to be when I accidentally ran out and didn't leave my bed the next day . My mood's okay, I feel reasonable stable and not too irritable. It's oddly nice how relaxing it is to not be on stimulants. I also like how today seems to be lasting forever, no more time dilation!

Couldn't do anything worthwhile right now but I'm not finding it too hard to function at a living standard either. Guess I could quit now and slowly recover from the dopamine downregulation and whatever other nasty things daily use has done to me over the last 18 months. Just got to get through my exams first. :)

I'm hoping to give up everything for good over the summer. I'm too prone to addiction to do drugs and the last 4 or 5 years of my life have done nothing but damage.
 
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I'm hoping to give up everything for good over the summer. I'm too prone to addiction to do drugs and the last 4 or 5 years of my life have done nothing but damage.

Well good luck anyway. :)
 
He's seems like a good guy, I don't think he was trying to be a dick. He probably just misread you, like I did initially, and felt you were being too heavy-handed.

I've been advising people not to drink on MPA as well. We think that thiopropamine is probably an MAOI so there's always the outside chance of dropping dead on a heavy night out if you're not watching your tyramine intake. Nothing in the short or long-term suggests it's a good idea.

Haha, usually I agree with you... Well I'll put it this way. SamuelG ticked me off. I was a bit hostile before that, too, but I think I just got ticked off seeing so many people recommend alcohol to "remove bad side effects"

I'm not that bad i promise, your diagnosis of an MPA induced rambling rant-a-thon is indeed accurate i was on day two of a 3 day MPA and lorazepam bender, Its almost impressive i could make vague sense let alone annoy you or anyone else involved which if I did, i am sorry for twasn't my intention I'm just annoyingly pedantic

I agree with you both (and the rest) that drinking to reduce negative side effects of a drug is fucking silly. Healthwise alcohol doesn't help anything except snake venom i read about once ,there was 200cc IV Vodka involved i think, using it to make things a bit more fun is one thing but too reduce negative effects is just begging for trouble.

Machete your mpa/eph hypothesis has gotten my brain whirring now, unfortunately its 5am and i've got nothing further to add to this until ive slept and scoured the free full texts on pubmed but the NDRI profile of it and your assumption of mpa's releasing effects fit in perfectly with a theory i've been having about MPA.... Damn i wish someone would do the pharmacodynamics work on MPA, perhaps we could all pool for a GC-MS and 100 healthy people?

On a slightly unrelated note FoolsGold did you hear back from the doc/dentist ?? I may have missed a post about it limited to my crappy backup phone :)
 
Leave MPA alone!!!! It's just trying to help you focus on boring tasks while appearing sober to other individuals. People who are after some sort of rush are looking for the wrong RC. This is a pure CLEAN, FUNCTIONAL stimulant.

Sounds like a vendor trying to chat up his products ;) Albeit in an extremely accurate way :)
 
what is this about alcohol and mpa and no-no?
i mean i always prefer my eph + alc but i do drink on mpa

mpa definitely lingers, as in you can redose and it be the next day if you are taking daily
fast tolerance, but very clean stim, very nice tingles for me orally 50mg
 
I'm not that bad i promise, your diagnosis of an MPA induced rambling rant-a-thon is indeed accurate i was on day two of a 3 day MPA and lorazepam bender, Its almost impressive i could make vague sense let alone annoy you or anyone else involved which if I did, i am sorry for twasn't my intention I'm just annoyingly pedantic

I agree with you both (and the rest) that drinking to reduce negative side effects of a drug is fucking silly. Healthwise alcohol doesn't help anything except snake venom i read about once ,there was 200cc IV Vodka involved i think, using it to make things a bit more fun is one thing but too reduce negative effects is just begging for trouble.

Machete your mpa/eph hypothesis has gotten my brain whirring now, unfortunately its 5am and i've got nothing further to add to this until ive slept and scoured the free full texts on pubmed but the NDRI profile of it and your assumption of mpa's releasing effects fit in perfectly with a theory i've been having about MPA.... Damn i wish someone would do the pharmacodynamics work on MPA, perhaps we could all pool for a GC-MS and 100 healthy people?

On a slightly unrelated note FoolsGold did you hear back from the doc/dentist ?? I may have missed a post about it limited to my crappy backup phone :)

Hey I just wanted to say that I appreciate you recognizing your mistakes and I myself will admit that I was being an asshole. It's just nice to see someone actually honest and modest enough to say the truth. Hell if I was in your situation I probably would have argued more. So for that, you're pretty cool.


On the main topic: I just learned that MPA is a releaser, not an agonist. That is fact. Now the speculation is, does that mean it is potentially a lot more damaging than other stimulants.
 
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