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RCs The Methiopropamine N-methyl-1-(thiophen-2-yl)propan-2-amine (MPA) Megathread V2

bloodshed344 said:
On the main topic: I just learned that MPA is a releaser, not an agonist. That is fact. Now the speculation is, does that mean it is potentially a lot more damaging than other stimulants.
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Purely in terms of dopaminergic neurotoxicity via oxidative stress, I'm pretty sure that its action as a releasing agent is bad news. I don't think dopamine receptor agonists can be neurotoxic in that way because they don't directly affect the levels of dopamine and therefore won't result in any extra hydrogen peroxide being released by dopamine destruction. I'm not sure how MPA compares to, say, methamphetamine in the neurotoxicity stakes because I'm not entirely sure how amphetamines work but I believe that MPA is also far more neurotoxic than comparable chemicals that act as reuptake inhibitors (e.g. EPH). I'm not certain but I don't think a dopamine reuptake inhibitor alone is likely to cause enough of an increase in dopamine concentration to result in major uncontrolled problems with free radical creation at the point of destruction (i.e. the precursor to neurotoxicity caused by oxidative stress). I'd be somewhat surprised if EPH was actually neurotoxic at all or at least significantly so.
 
Synthacaine isn't an analog of cocaine. Synthacaine is just a brand name, could be anything (probably a mixture of things). Be weary of "glowing" reports of branded RCs, especially when these reports are posted in the MPA thread and aren't really on topic (unless "synthacaine" is actually MPA - but there's no way to tell that one way or the other) I would never ever touch anything that is brand-named. Chances are you're getting a mixture of chemicals. Taking unknown chemicals is not harm reduction.
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I tried Synthacaine a while ago and it was definitely MPA with a numbing agent. It's going pretty cheap atm and I've run out of MPA. I just don't want to get it and find out they replaced it with something else.
 
lynx2051 said:
I agree with the vasoconstriction, but it is very stimulating in my opinion. Did you mean there is no proper stimulation because there isn't much euphoria?
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Proper stimulation : no signs of yawning, alert mind, light anxiety, hyper focus. MPA was for me a vasoconstrictor with stimulating side effects :) Forgot to mention, that I primarily used the intranasal ROA. That could be the cause of the pronounciation of the side effects. Ingested orally just a tiny amount and I can remember, that it felt somewhat less toxic. Nevertheless I always got a rather massive headache from MPA in the end on the backhead. I rarely get headaches, that is definately a warning sign for me. Please take care when dosing this unapproved analogue.
 
Just bombed 40mg of synthacaine and I am pretty certain it's MPA but feels piss weak. Hardly any stimulation, wouldn't surprise me if it has been cut with pyrazolam (as it's water soluble) cos it almost has a dopey feeling to it.

This IS MPA I'm certain. Likely mixed with DMC and quite possibly a downer too.
 
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Although I haven't tried other ROA's myself (I mainly stick to plugging because it's the least hassle IMO), my experience of 50mg of this substance plugged seems much better than insufflation.

I highly recommend that you try plugging this chem if you haven't already. It's definitely an experience I can't wait to repeat. Although, after my initial 50mg dose, I just couldn't reach that clear-headed feeling again after it had worn off. I tried another two doses of 50mg but these just increased body load and extended the duration of the stimulation waaaay past bed time.

I probably shouldn't have done this the night before my Chemistry exam.
 
can anyone else comment on MPA and body odor?
haven't used in well over a week, yet i continually and distinctly, randomly smell MPA.

when using i also noticed the smell, in my pit sweat, finger-nails and while passing gas.
i only oral dose this chem, i have insufflated before but find it semi-unreal it is still lingering in my nose.. or even my body? metabolite?
 
Does use of this drug or any kind of drug, eg MDMA, Amphetamine, lower testosterone levels?
 
DubNaut said:
can anyone else comment on MPA and body odor?
haven't used in well over a week, yet i continually and distinctly, randomly smell MPA.
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I get terrible MPA body odour and also get it in my fingernails. I guess it's just metabolised and excreted slowly from your system. There might be some residual build up somewhere other than the blood and that's the reason it's staying for this long. This is literally just me speculating though. But yeah, I get the same.
 
I get terrible MPA body odour and also get it in my fingernails. I guess it's just metabolised and excreted slowly from your system. There might be some residual build up somewhere other than the blood and that's the reason it's staying for this long. This is literally just me speculating though. But yeah, I get the same.
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Sweaty feet too.
 
Part Time Junkie said:
how do you guys compare it to EPH? Also do they mix?
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EPH is much more stimulating and and has highly unfocused driven mind set to it, huge euphoria however. I found myself having 20 tabs in FireFox open reading up any and everything but never being able to get myself to stick to one thing. I wouldn't recommended mixing with EPH as two stimulants IMO is dangerous and will worsen the comedown. MPA is stimulating with a bit of euphoria, but isn't as moreish once it's worn off. Where EPH because of the euphoria you want to do more, it does burn your nostrils up and will leave you with a blocked nose for weeks in my experience.
As people have said, MPA is much more just a clean stimulate by which I mean the little euphoria doesn't get in the way. And it doesn't have a paranoid edge to it letting you get on with what you want to do where as EPH (depending on the dose) you just sit there. Looking up everything listening to fast music not knowing what's going on, which for me I didn't enjoy. MPA is better for waking up and going out, as you won't look like your obviously buzzing. But you can enjoy music more on it but it isn't no where no as euphoric as EPH which is good if you're looking that for that kind of stimulant.
The main downsides to EPH is how dose sensitive it is, don't even THINK about just eyeballing it this is a chemical you defiantly need to use scales with. Otherwise you will end up accidentally taking to much, causing an overdose which can only be described as a typical amphetamine psychosis. Redosing eventually just makes the euphoria go and you're just left with pure anxiety driven stimulation, always have some downers on hand when doing stimulants. Better safe than sorry. :)
 
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Does use of this drug or any kind of drug, eg MDMA, Amphetamine, lower testosterone levels?
 
I should have put abuse of drugs. As I had a blood test done & beverything was low. Then i stopped all drug use for a month and all my levels were back to normal.
 
I've decided to give up MPA. Whenever I was on it my faeces would be almost black or dark green in colour.
 
sack both these now mpa and eph i can get a good supply of mdpv if i fancy it which is very very nice lol p.s. to you wanting to try 3,4,ctmp warning it is the stim version of phenazepam for me meaning its the devil in disguise over 2 weeks to come down from 250 mg mistake only just started sleeping properly and you can feel that the stuff has altered you at a base chemicals level in your brain its weird to explain but i really would tell you all to think twice strange from being the mxe of stims to the phenazepam of them in a month lol :)
 
Dunno said:
I should have put abuse of drugs. As I had a blood test done & beverything was low. Then i stopped all drug use for a month and all my levels were back to normal.
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Opiates lower testosterone levels (as do many drugs but opiates are the most obvious), do you take opiates?

EDIT: Post 666!
 
foolsgold said:
sack both these now mpa and eph i can get a good supply of mdpv if i fancy it which is very very nice lol p.s. to you wanting to try 3,4,ctmp warning it is the stim version of phenazepam for me meaning its the devil in disguise over 2 weeks to come down from 250 mg mistake only just started sleeping properly and you can feel that the stuff has altered you at a base chemicals level in your brain its weird to explain but i really would tell you all to think twice strange from being the mxe of stims to the phenazepam of them in a month lol :)
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MDPV is an evil chemical, I would advice you to stay away from it myself. Since it's illegal and there are other better chemicals out there *cough drone *cough.
 
not for me the is not mate its what saved me a few years ago from a half/oz speed habit killed it dead . was just bragging a little with ive found a good supplier but really i think its time to move back to an old friend or get of my arse earn so money and get myself a chemist and lab :)

right some of you will remember me saying that the doctor had sent me to get something in my mouth checked for cancer because of vaping stuff well its not cancer but is down to it the heat has made my gums make calais like you get on your hands and thats what it was . but if you see any white spots on gums best to get it looked at
 
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