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Gabapentinoids The Lyrica (Pregabalin) Mega Thread v 2.0

higherconciousness said:
My ability to build up a tolerance to lyrica has been kind of all over the place. I’ve been using it relatively consistently for past couple of years in stints of 3-4 month binges with some breaks in betweeen. Dosages have ranged from 300-450 all the way up to 1200mg daily. Sometimes tolerance doesn’t build too rapidly and goes back down quickly. Other times it seems like it’s the inverse, so it’s been quite of unpredictable in that regard.

I think it mixes well with all substances, perhaps not in excess with alcohol, but especially with benzos, somas, stimulants (in low dosages), psychs, and dissociatives.

The past few months I managed to stay below 600mg, but that was mostly due to being in school. Seemed like anything of 300-450 mg would start to inhibit cognition, so I tried to keep in lower range. Now I’m completely out. Usually the withdrawals are pretty mild and manageable for me, but I think the fact that I have Covid is making it more difficult.
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I got to the stage where I was using many many grams in one go to achieve that pleasnt trippines effect (something I've never experinces from Benxos). I know that is a crazy amount, but even when I abstain for weeks it doesnt seem to reduce my tolrence for it
 
A question for those with experience with both or every day users or ex-users. If someone was using this in purpose like daily 450mg pregabalin with occasional benzo in terms of day after lowering dose of pregabalin on 150mg with alprazolam or Lorazepam.
The thing is due to a possibility of not having Lyrica in my daily dose of 600mg which sometimes I take 450mg and before sleep 150 or 300 depending on intensity of my fybro, this Christmas weekend I have bunch of Xanax XR and Lorazepam a few, but could come short(not able to reach my doc) meaning I'm left with 5x150 mg pregabalin till Tuesday.

So I thought spacing daily 150mg pregabalin with adding benzo on top to not be in withdrawal for Christmas?

Or skip a day of pregabalin and take benzos instead?
 
i am on preg daily 2x200 mg and broma and today i only took broma feel no withdrawl. had one cold turkey lyrica 600mg daily and it was managble. hope that helps in a way.
 
kongoman said:
Today I took 900mg pregabalin with 240mg methadone and I feel almost nothing. I have trembling hands and tics in limbs.
Im dissiluniosed with this drug. I take at night to help sleeping and one day a week to potentiate methadone. But today only feel side effects.

Kongoman
❤️❤️❤️❤️
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My flatmate tried it yesterday and had no effect at all, very strange drug. I reckon what's going on here is that these euphoric manic-like feelings from pregabalin happen in someone who has a natural bipolar tendency - a tendency towards mania. A personal friend of mine also gets stimulated and manic from it, but she has diagnosed BPD. I myself have BPD too.
 
I think that these two drug classes are too different to fully substitute for each other. Meaning you'll eventually still get withdrawals but you might get away for some time by cycling. But you'd have to cycle like 3 days on benzos, 4 on pregab, or every second day on the other if you can do that but it sounds messy to me,

Wonder whether RLS drugs like pramipexole or ropinirole would help with the akathisia on days w/o pregabalin.
 
candidsurprise said:
My flatmate tried it yesterday and had no effect at all, very strange drug. I reckon what's going on here is that these euphoric manic-like feelings from pregabalin happen in someone who has a natural bipolar tendency - a tendency towards mania. A personal friend of mine also gets stimulated and manic from it, but she has diagnosed BPD. I myself have BPD too.
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What dosage did he try?

Without tolerance one should absolutely feel anything of 300mg or more. I knew somebody who couldn't resist the urge to sleep from maybe 250mg. I got a drunken state from 300mg (w/o tolerance) or a dissociative/stimulant/empathogenic like effect from 900mg's.
 
I'm aware it's messy and familiar from the past but I think I got no choice but then again its just couple days so just....maybe I'm comforting myself cause it was like
Pregabs hold off benzo withdrawal in my case not full but no insomnia, while the other way round it's no sleep and the rest
 
I have been taking large doses of Pregabalin for a couple of weeks, about 2500mgs or a bit higher, I have about 25000mgs left and a balance owed to me on a prescription so I am at about 37000mgs all together, any advice,
 
Blindmikeyc said:
about 2500mgs or a bit higher
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2.5g a day?
May I ask why this dose is so high, how long have you been on it (at this dose) and the reason why pregabalin was prescribed in the initial decision to Rx?
Thanks and welcome to bluelight.
Will be around a while but others will be along, surely. ;)
Take a moment for yourself while the wheels turn, OK?
Peace
 
Did you try to use less or to skip a dose and what withdrawal effects did you get?

I was using 900mg/d at the end and quit it without adverse effects. But I know that most people get quite nasty withdrawal from stopping pregabalin.
 
Well I have had fun using it for obvious reason but I need to stop and go back to normal dose or just quit it completely
 
fastandbulbous said:
That last little bit, regardless of drug, is usually the hardest bit...
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This

This is absolutely accurate

IME tapering isn’t difficult; the jump off is.

For example, I had no issue dropping a methadone dose from 80mg to 4mg; and in a different year from 75mg to 6 mg. The last few mg were the only ones i noticed the drops.

When i had to stop methadone due to long QT syndrome, they switched me to morphine in the hospital. Knowing no doctor would maintain me with morphine, I requested that they cut my dose in half every 48 hours

I went from 120 mg per day to 7 mg per day in about a week and a half. A doctor agreed to write a prescription for the next week so I wouldn’t jump off of 7 mg
I couldn’t jump to 0 Started using small amounts of dope

Back to your question: at the mega doses youre taking I strongly suspect you can cut down quickly to a lower dose without much issue

When you are at “normal” /common dose, you will probably have to go a bit slower, but if I read your question correctly you have only been taking the pregabalin for a few weeks

Therefore it shouldn’t be built up in your system as it would if you’d been taking it for years

So I really think you should easily be able to just taper quickly and painlessly
 
Yeah. I was able to taper from 600mg/d morphine to 90mg/d with little discomfort but then it became increasingly difficult. Memantine changed this though, and I didn't have to go through withdrawal. Maybe dissociatives can help with pregabalin taper as well, at least I'd say it would be worth a try if you can get any of the long acting ones, preferrably memantine but also e.g. deschloroketamine or even DXM as a last resort if you can get nothing else but I'd be careful with DXM because of its SNRI activity (and those high trapping dissos are no joke, I know of more than one person who overshoot the dosage and encountered stuff like the devil with eyes open). I never got such eerie stuff from DCK but it helped me to do a cold turkey off 4mg bupe.
 
I used to take 60 300 mg capsules a day first cut that by half 30 300s enough no wd then did cuts every 4 days until i got to 10 300 mg a day then a slow months long taper until i jumped at 150 mg a day with help of diazepam and it was so bearable i was thinking I'm going to get a wd but it was easy. When i have jumped from massive amounts it was hell
 
Lil'LinaptkSix said:
2.5g a day?
May I ask why this dose is so high, how long have you been on it (at this dose) and the reason why pregabalin was prescribed in the initial decision to Rx?
Thanks and welcome to bluelight.
Will be around a while but others will be along, surely. ;)
Take a moment for yourself while the wheels turn, OK?
Peace
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Pregabs build tolerance so quick that the amount you take just to feel a buzz becomes crazy .
 
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