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Gabapentinoids The Lyrica (Pregabalin) Mega Thread v 2.0

If, without any tolerance, I were to take 200mg of pregabalin in the evening for mild recreational effect, would I have any trouble going to sleep when I wanted? (I appreciate that it generally helps with sleeping, but can it do the opposite too?)
 
Lyrica is probably one the best medications for anxiety I’ve ever encountered. The duration of action and lack of rebound anxiety makes it an ideal substance to combat my overwhelming stress. 600 mg absolutely obliterates my GAD and allows me to function at a higher capacity. I guess the only downside is that it slightly affects my concentration and memory, but it’s still nowhere near as bad as benzos. I don’t get extreme euphoria or anything, but I definitely feel pleasant.
 
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higherconciousness said:
I’m not sure if it’s ketamine tolerance, but I felt like the lyrica hampered the kets effects.

Nothing works anymore WTF?
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Really? I think they really compliment each other I also find when I'm out of it on pregabs lines and hits of k hit me harder /will black me out easier.
What sort of tolerance do you have to ketamine?
 
jhjhsdi said:
Really? I think they really compliment each other I also find when I'm out of it on pregabs lines and hits of k hit me harder /will black me out easier.
What sort of tolerance do you have to ketamine?
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I used to use a ton of dissociatives 4 years ago, but have been relatively clean the whole time. This class of drugs has always been one of my favorites. I just started using K a month or so ago. At first 150mg would have me flying. I began using it 4 days a week and after the first week there was a mild increase tolerance. Out of no where and seemingly over night my tolerance went through the roof. I did 175mg line and the subsequent effects were quite disappointing. I need 400mg to really get somewhere and it blows.

For me Lyrica seems to inhibit the effects of most drugs with the exception of other downers. Perhaps it’s because I dropped MDMA the night before I tried this combo and my brains depleted on all fronts. After a week break I’ll try it again.
 
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higherconciousness said:
Lyrica is probably one the best medications for anxiety I’ve ever encountered. The duration of action and lack of rebound anxiety makes it an ideal substance to combat my overwhelming stress. 600 mg absolutely obliterates my GAD and allows me to function at a higher capacity. I guess the only downside is that it slightly affects my concentration and memory, but it’s still nowhere near as bad as benzos. I don’t get extreme euphoria or anything, but I definitely feel pleasant.
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I think lyrica is very good for GAD but it produces dependency with extended use, I am trying to quit but it becomes very difficult because of withdrawal
 
jhjhsdi said:
Really? I think they really compliment each other I also find when I'm out of it on pregabs lines and hits of k hit me harder /will black me out easier.
What sort of tolerance do you have to ketamine?
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lyrica seemed to increase the effect of ketamine (when I was using it)
I miss K a lot, I liked to combine it with acid sometimes
 
Nicocastillo7 said:
I think lyrica is very good for GAD but it produces dependency with extended use, I am trying to quit but it becomes very difficult because of withdrawal
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4 years ago I was prescribed lyrica. I was on it for a year or so and when it came time to get off of it I didn’t experience severe withdrawals. Compared to benzos it was a walk in the park. It appears some or more prone to symptoms of lyrica withdrawal. Nonetheless I’ll be careful not to over do it.
 
Anyone used this with 1,4-butanediol? Just got a half of liter and I’m a bit concerned of keeping my use in check. I’m guessing this combo might be sketchy. I took 600mg about 5 hours ago.

I decided against the combo. I’ve been a little reckless with my soma usage. Between that and my occasional benzo use I’ve been relentlessly hammering my gaba-a receptors. I woke up yesterday in a state of sheer panic. My body was extremely achy and the hypersensitivity was pretty intense.

I took 600 mg of pregabalin and it completely obliterated my symptoms. I’m hoping that since it doesn’t alter gaba levels it won’t end up exacerbating my withdrawals. I just have to be careful not to overdo the lyrica.
 
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With no tolerance, my partner and I each dosed 150mg at ~7PM to test the waters. I had microdosed ALD-52 in the morning and was already pretty tired out even before dosing. At this does by itself, I can say that we both felt something close to being tipsy; in addition, my tiredness was magnified. We both smoked weed and it synergized better than I had expected. We had some great conversations, had some amazing sex, and watched a movie. Overall mild but pleasant effects for a short night.

We both slept well, but had to get up at our regular early time the next morning and both of us had a really hard time getting out of bed. We both still felt pretty sedated and spacey the next morning. This makes me leery of doing a bigger dose if we have any responsibilities the next day (we have kids).

For what it's worth, I decided to microdose again that next morning. I expected blunted effects since I still felt the sedation from the pregabalin but, counter-intuitively, the microdose was actually significantly stronger than usual. This can happen for all sorts of reasons of course. No idea if the pregabalin played a role, but it was surprising.
 
Hey, long time since i posted

So im prescribed Lyrica since 2/3 months ago. Started on 50mg or 25/25mg per day then up to 100mg or 50/50mg per day. The gp wont prescribe me any higher and i have to wait for Psychiatrist review (Which should be soon)
I weigh nearly 100kg. Im right in thinking for 3 months @ 100mg a day this dose is way too low for me? it was for anxiety , it doesnt have any effect really in that department so far.

Also I wanted to know of the Safety + Interaction of Pregablin and other drugs such as: Cannabis and Ecstasy
 
Darksidesam said:
Hey, long time since i posted

So im prescribed Lyrica since 2/3 months ago. Started on 50mg or 25/25mg per day then up to 100mg or 50/50mg per day. The gp wont prescribe me any higher and i have to wait for Psychiatrist review (Which should be soon)
I weigh nearly 100kg. Im right in thinking for 3 months @ 100mg a day this dose is way too low for me? it was for anxiety , it doesnt have any effect really in that department so far.

Also I wanted to know of the Safety + Interaction of Pregablin and other drugs such as: Cannabis and Ecstasy
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I have been taking Lyrica for a long time and have combined it with many drugs. With cannabis it goes well, there is a synergy between pregabalin and cannabis. And with mdma it felt good, it calmed down the anxiety a bit and it was very euphoric.
Also I have combined it "without the intention of doing it" with ketamine, tramadol, oxycodone, alcohol, nbome and lsd, without problems but we are all different.
 
Nicocastillo7 said:
I have been taking Lyrica for a long time and have combined it with many drugs. With cannabis it goes well, there is a synergy between pregabalin and cannabis. And with mdma it felt good, it calmed down the anxiety a bit and it was very euphoric.
Also I have combined it "without the intention of doing it" with ketamine, tramadol, oxycodone, alcohol, nbome and lsd, without problems but we are all different.
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thank you for the reply this is helpful
 
Does it kick in quicker if you open the cap and swallow the powder or does it have something to do with the powder being broken down or is it the actual capsule? becausee i've noticed no difference oh and this stuff is gooooooooooooood for sleep
 
Hey all, welcome to my first post.
I'm currently taking some 3-ish mg (sometimes 2 mg, sometimes 5 mg)of clonazolam throughout the day and start to experience now, 3 weeks in, I experience first WD symptoms Also had just switched from an etizolam-diazepam rotation for some weeks, 90 x 10 mg Diazepam, 200 x 1 mg etizolam all original pharma with a one week phenibut break afterwrads.
I was now put on Pregabalin, too by a psychiatrist, just started this week at 2x75 mg per day, which makes me quite sleepy, but I feel the clona has fucked up my day-night rythem already, ever so slightly. I wake up early, don't feel I get enough sleep. The pregabalin doseage will be adjusted in a while to yeald first good results and I'll have a phone call bc of something else with my GP, but will mention the pregabalin, though the psych-doc gave me a 3-weeks supply and told me to up the dose at the end of this instead of after the first week.
So here is my issue: I want to get off the clona asap, as it feels like it's becoming more and more of a problem (higher and higher doses to somewhat function, side effects). So I was wondering about your best advice here? My clona supply is in solution and, considering my dosage, virtually unlimited. Should I try something like a taper or do you think I might get away with just doubling the Lyrica and stopping benzos? Or should I try to substitute with phenibut, of which I still have a small amount in solution. All the benzos have so far only been helpers I just enjoyed my life again, started making conversation, started meeting with people hand talk to them over some coffee... nothing of this would have happened without the benzos. And no neative effects. Till Clone. I'm now really scared after discovering the 100 mg clone/day thread and hope I can make it short and painless, though that might mean waving my newly wone social comptence goodbye. If the kyrice doesn't catch it soon...
I'm also on 60 mg Methadone, but I think this doesn't really matter here.
I hope someone here can help me kick off the clona as soo as possible.

Thank you for your advice in adcance!
 
Considering how strong clonazolam is your doses aren't actually low and therefore you should definitely taper. A good rule of thumb when tapering down with benzos is to reduce the dose by 25% at the time. Then you should stay on that dose for 2 weeks and then reduce your dose by 25% again. And then repeat until your ready to drop down to zero.

I was advised to do tapering this way by a psychiatrist who i trust and has never disappointed me. I guess some people might need lesser of a dose reduction to be able to stay on the lowered dose but that's at least a good starting point. No reason why you couldn't adjust this protocol to make it feel comfy for you.

Edit: First of all you'll have to find out what is the daily dose that allows you to feel ok and stable. Only after that you can start tapering. Stop alternating your daily dose.
 
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Oh, tht's what I suspected. Many thanks for your hoest reply. Yes, I'm at the moment taking it whenever I start to feel low, don't really know how much I'm on.
I was thinking about waiting tilll I really feel it, get all shaky, can't sleep anymore, feel mpending doom and anxiety and then try something like 0.5 mg.
 
Specified said:
Does it kick in quicker if you open the cap and swallow the powder
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It could be my imagination, but it seems to kick in quicker when I pour the powder under my tongue and let it dissolve before swallowing (it's bitter, but I kind of enjoy it for some reason). The capsules dissolve pretty quickly though, so I doubt there's much of a difference between swallowing the powder or swallowing the whole capsule... I generally give it a couple chomps anyway just to get it going if I don't feel like opening it up to get at the powder.
 
Colonel Contin said:
It could be my imagination, but it seems to kick in quicker when I pour the powder under my tongue and let it dissolve before swallowing (it's bitter, but I kind of enjoy it for some reason). The capsules dissolve pretty quickly though, so I doubt there's much of a difference between swallowing the powder or swallowing the whole capsule... I generally give it a couple chomps anyway just to get it going if I don't feel like opening it up to get at the powder.
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Interesting.
 
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