The Large and Nifty Not-quite-advanced Drug Chemistry, Pharmacology and More Thread

[DeMiZe-420-]

is it possible for the neurotransmitters destroyed in your brain from drug use to be repaired/restored?

 

[MagickalKat777]

is it possible for the neurotransmitters destroyed in your brain from drug use to be repaired/restored?

They're all repaired eventually... The brain isn't born with a set amount of a given neurotransmitters which are used for the rest of your life. Neurotransmitters are used and expelled and replaced just like blood cells are. The problem is that most people don't give their brain enough time to recover or they don't give their brain the fuel it needs to replace those lost neurotransmitters.

Example: L-Glutamine - GABA
5-HTP or L-tryptophan - Serotonin
L-tyrosince - Norepinephrine

 

[MurphyClox]

... "destroyed"... "repaired" ... come on guys, we are talking about living systems here. The compounds may get catabolized or anabolized or transformed but nothing is 'destroyed' here. Don't get too sloppy with these terms please.

- Murphy

 

[ebola?]

I believe that the poster was intending to ask about whether if background intercellular levels of a given neurotransmitter fall, the brain will reattain the prior homeostasis at some point. Of course, without knowing the specifics of which neurotransmitters are involved and which mechanisms caused this homeostatic shift, no one can say much.

For most recreational drugs, I'd concern myself more with receptor-downregulation, excito-toxicity, and mitochondrial damage due to free-radical formation.

ebola

 

[Lombergerh]

I'm a little confused:
Bufotenine(5-HO-DMT) is the ether of psilocin(4-HO-DMT) ?
5-meo-dmt is the ether of bufotenine?
If it is wrong, 5-meo-dmt is the ether of what substance ?

 

[MurphyClox]

^5-MeO-DMT is the methyl-ether of bufotenine. As you already wrote correctly, the OH in psilocin is in position 4 and won't move. The methyl-ether of psilocin is - surprise, surprise - 4-MeO-DMT.

- Murphy

 

[dread]

Bufotenine is a structural isomer of psilocin.

 

[<pyridinyl_30>]

I was just reading a thread over in Psychedelic Drugs about N-BOMe-Mescaline, and it made me wonder:

Are N-(2'-methoxybenzyl)-amphetamine's and N-BOMe-MDA's effects known?

I know that the former is related to benzphetamine.

 

[Vader]

There are multiple reports of freebase DMT being active when snorted. My understanding was that, as it is not water soluble, it would not be absorbed by the mucous membranes, and would end up being swallowed and chopped up by MAO. What am I missing?

 

[ebola?]

There are a couple of exceptions to the non-water soluble, non-insufflatable rule.

ebola

 

[Vader]

Evidently, but could you explain why this is please? I just don't get it.

 

[mukaki]

Hey

I'm just wondering if Kava MAO inhibition is significant enough to cause problems with taking common anti-depressants, in this case Edronax (reboxetine (an NRI)). I've taken kava three times with no ill effect except maybe a little elevated heart rate the first time, but that might have been placebo. Then I read about that an alkaloid functions as a MAOI-B, so now I'm wondering, am I hurting myself or is it just not powerful enough when the alkaloid is not pure and therefore is in small dosages.

Dunno if this is really a simple question, but I don't want to start a new thread if it's completely obvious

 

[Sturnam]

MAO-B selective inhibitors are not nearly as dangerous as MAO-A inhibitors, so it's good that it's MAO-B selective. As far as danger, I would say just listen to your body, and if you think that your heart rate or blood pressure is too high, then stop using.

 

[mukaki]

Thank you

 

[ebola?]

Because MAOA preferentially metabolizes NE and 5HT, selective inhibition of MAOB (which preferentially metabolizes DA) shouldn't theoretically prove very dangerous. In all likelihood, the inhibition from Kava is weak, but please take care, and listen to your body, and also dose such to avoid crossover into MAOAI (if this is possible).

ebola

 

[Captain.Heroin]

Evidently, but could you explain why this is please? I just don't get it.

Other examples of drugs you can snort, but are not water soluble, would be benzodiazepines such as triazolam.

im totally stumped. ive never used a drug where iv use was not far superior to oral.

Flurazepam seems to work better orally as well.

 

[dread]

Other examples of drugs you can snort, but are not water soluble, would be benzodiazepines such as triazolam.

Triazolam is water soluble at least as the tartrate salt (in which form it is most often supplied.)
Same with midazolam. IIRC this is due to each having an azole ring (imidazole or triazole) which is basic enough to form a salt.

The vast majority of benzodiazepines however do not have this property and are inactive if snorted.

 

[Antavio09]

Anybody have anything to add to my op prep?

It requires the pill to be ground into a fine powder, preferably with a metal file. THE PILL CANNOT GET WET WHILE GRINDING. I am basing this off 40mg op that I have been experimenting with.

1. grind pill to powder
2.get container place 4cc's of h2o2(hydrogen peroxide) and 4cc's of white vinegar together, then mix.
3.place op powder into mixture.
4.swirl container containing solution to mix up.
5. leave container for hour it will completely break down. no goo like with the coke method.
6.Once broken down, you are not finish this mixture is not yet ingest-able. the hydrogen peroxide has to be broken down into its baser elements.
7.Heat the solution to 120f-150f or very low on a stove top.
8.As you do this the solution will slowly evaporate which is ideal as to not to destroy the oxycodone. The low heat breaks the bonds of the peroxide by turning it into its two harmless components water and hydrogen.
9.As you heat all of the solution away You will be left with your final product stuck to the bottom of the solution container.

 

[seep]

It requires the pill to be ground into a fine powder, preferably with a metal file. THE PILL CANNOT GET WET WHILE GRINDING. I am basing this off 40mg op that I have been experimenting with.

1. grind pill to powder
2.get container place 4cc's of h2o2(hydrogen peroxide) and 4cc's of white vinegar together, then mix.
3.place op powder into mixture.
4.swirl container containing solution to mix up.
5. leave container for hour it will completely break down. no goo like with the coke method.
6.Once broken down, you are not finish this mixture is not yet ingest-able. the hydrogen peroxide has to be broken down into its baser elements.
7.Heat the solution to 120f-150f or very low on a stove top.
8.As you do this the solution will slowly evaporate which is ideal as to not to destroy the oxycodone. The low heat breaks the bonds of the peroxide by turning it into its two harmless components water and hydrogen.
9.As you heat all of the solution away You will be left with your final product stuck to the bottom of the solution container.

interested in this. Can you specify whether you used 3% or 6% peroxide? Also, if it interests you, you may want to try to measure the melting point of your extract. You don't need a melting point apparatus you can McGuyver a Thiele tube (watch The French Connection from 52:00 to 54:00 they show it very clearly).

 

[mukaki]

Because MAOA preferentially metabolizes NE and 5HT, selective inhibition of MAOB (which preferentially metabolizes DA) shouldn't theoretically prove very dangerous. In all likelihood, the inhibition from Kava is weak, but please take care, and listen to your body, and also dose such to avoid crossover into MAOAI (if this is possible).

ebola

So it wouldn't theoretically be dangerous because I take no other drugs that mess with dopamine, whereas if I was to take a MAOBI with for example cocaine it would end in psychosis?

Thank you for your response btw.