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The Large and Nifty Not-quite-advanced Drug Chemistry, Pharmacology and More Thread

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Would an SNRI (desvenlafaxine) be contraindicated with o-desmethyltramadol? Since o-desmethyl lacks the serotonergic affinity that tramadol has, I'm thinking the combination would be safe, but I just wanna make sure.
 
I dunno, I would guess probably not. I mean, I've taken DXM with SSRIs which is contraindicated but I'm still pretty alive.
 
Mephedrone

Does anyone know how mephedrone works in the body? Like the actual chemistry of it.
 
increase solubility of phenazepam the old way

Is it possible to do this with some of the old was youd turn some brown into some number 4 shooting dope,



Ie: citric acid? raise the ph with a little Hcl?

Apart from that,


Even though this is defenitely not H20 soluble, Does that mean that one its in the body, and because of it highly liphphilic nature that it will reach the brain faster (think why Diaceytlmorphine reaches the brain).


I mean, we can dissolve the shit in anything common enough, but if you shake it up enough in a fit and then shoot away, It should produce some prety immediately noticeable effects right????? (i know iknow, pay attention to measurements, carefully, but this is not eyebealling.) Im just worried that people are going to do this anway, and in the intersts of harm reduction what is the relevent info that should be spreaded about this practice.

It seems some people just have to shoot everything.....
 
If you wanted you could make a solution similar to the lorazepam injectable. Phenazepam is similar in structure to lorazepam and probably has similar pharmacology/dynamics, but with different pharmacokinetics...

In other words you would want PEG400-propylene glycol with a preservative like BnOH. This solution would need to be micron filtered.

Do not inject powders not in solution. This is how you lose limbs...
 
rollnpeace said:
Does anyone know how mephedrone works in the body? Like the actual chemistry of it.
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It is thought and highly likely that it releases serotonin, norepinephrine and dopamine, similar to methamphetamine.
 
Codeine ceiling

Wikipedia, in its article on codeine, flatly denies that there is a codeine ceiling effect. Who is right? Why?
 
Wikipedia is full of itself and there is indeed probably a ceiling effect for codeine:

Psychopharmacology (Berl). 1998 Nov;140(2):191-201.
Subjective, psychomotor, and analgesic effects of oral codeine and morphine in healthy volunteers.
Walker DJ, Zacny JP.

Department of Anesthesia and Critical Care, University of Chicago, IL 60637, USA. [email protected]
The subjective, psychomotor, and physiological effects of analgesic doses of oral codeine and morphine were examined in 12 healthy volunteers. Subjects ingested placebo, morphine 20 or 40 mg, or codeine 60 or 120 mg in a randomized, double-blind, crossover design. The smaller and larger doses of each drug were putatively equianalgesic, and the cold-pressor test was included to test this assumption. Codeine and morphine increased ratings of "feel drug effect" but had little effect on other subjective measures, including the Addiction Research Center Inventory, visual analog scales, and adjective checklists. The few subjective effects that were observed were modest and were dose-related for morphine but not for codeine. The drugs did not affect performance on Maddox-Wing, digit-symbol substitution, coordination, auditory reaction, reasoning, and memory tests. Dose-related decreases in pupil size (miosis) were observed following codeine and morphine. Ratings of pain intensity decreased in a dose-related manner for morphine but not for codeine. Plasma codeine and morphine levels varied as an orderly function of dose. These results suggest that oral codeine and morphine are appropriate drugs for outpatient pain relief because they are effective analgesics at doses that have only modest effects on mood, produce few side effects, and do not impair performance. The results also suggest a possible ceiling effect of codeine on analgesia and subjective effects.
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http://www.ncbi.nlm.nih.gov/pubmed/9860110

My guess is that it is related to it's need to be metabolized into morphine by another P450 enzyme or to C-6-G. Codeine-6-glucuronide is another active metabolite that provides mu-opioid agonistic effects.
 
Cloudy said:
I've never had a problem with chemsketch, though I haven't honestly used it much.

Anyway, I'm a chem major who currently in Organic I, just finishing up reactions of alkenes and alkynes, and I'm trying to start learning basic pharmacology, and my school doesn't seem to offer anything of the sort, with the exception of forensic toxicology (?). I've found some good info (I haven't taken a full look yet, though) on MIT's open course website, but I'm curious as to if there are any sources that you guys recommend?

Thanks
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Find books on pharmacology. Both e-books and real books are good. Depends which area of pharmacology you're interested in really. Looking through journals helps, and your school will probably have access to pretty much all of them. Some basic neuroscience helps. Also, try independent study. Email a professor and say you'd like to work with them.
 
reuptake inhibitors vs releasing agents

Do stimulants that are mainly reuptake inhibitors feel subjectively different to ones that work mainly by acting as a releaser, feel different for that reason?

I guess what i'm trying to ask is, since I love d-amphetamine & d-meth (and even BZP), and similar stimulants, but I find methylphenidate / desoxypiperadol / MDPV etc kind of shitty.. is it because of them acting as releasers vs uptake inhibitors? Or is it something else like the ratio of effects on DA/NE/SERT..

It just seems that the releasers i've tried work WAY better, feel better in some way that the DA reuptake inhibitors i've tried severely lack.
 
The releasers usually cause greater levels of monoamine release than the reuptake inhibitors. Though d-AMP and METH also have about even levels of DA/NE release, whereas the only reuptake inhibitors on the market that do are dextromethylphenidate and cocaine. Regular old methylphenidate I can barely even feel for some reason, and it has a much higher affinity for NE than DA. Same with MDPV, most likely.

DA/NE reuptake inhibitors are most of the time selective for NE over DA, probably just for the reason of the NET being more promiscuous.
 
The releasers usually cause greater levels of monoamine release than the reuptake inhibitors. Though d-AMP and METH also have about even levels of DA/NE release, whereas the only reuptake inhibitors on the market that do are dextromethylphenidate and cocaine. Regular old methylphenidate I can barely even feel for some reason, and it has a much higher affinity for NE than DA. Same with MDPV, most likely.

DA/NE reuptake inhibitors are most of the time selective for NE over DA, probably just for the reason of the NET being more promiscuous.
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Ahh.. thanks for that info. Amphetamines are really calm and relaxed.. mephedrone is also (but prob from the serotonin), MDPV and methylphenidate cause too much "sketchyness" and anxiety. I wish there was a real good cheap research chem stimulant that was as relaxed as amphetamine.
 
quick question: im researching the history of methylphenidate and i cannot find info about where it was initially synthesized, and who was responsible (although im pretty certain it was in italy as the first paper on its synthesis is in italian) anyone know a bit about its genesis, aside that it was marked by ciba etc?
 
Methylphenidat was synthesized for the first time im 1944 by Leandro Panizzon (indeed italian) at Ciba (now Novartis; based in Basel, Switzerland; so it's practically a swiss invention, not a italian one). The tradename "Ritalin" is said to be derived from his wife's name Marguerite ("Rita").

- Murphy
 
Richard L. Myers, in "The 100 most important chemical compounds: a reference guide", states that it was named after his wife because she was the one who did the first human bioassays of the compound and found it be a stimulant. She had low blood pressure, so the compound treated the condition and she would often take it before tennis. The original name was "Ritaline" instead of the abbreviated "Ritalin". Quite a story!

The original synthesis starts with 2-Cl-pyridine and Benzyl cyanide. I won't detail the rest, but you should be able to figure it out!
 
This isn't remotely advanced, but I don't think I'll get good info in OD:
what can I do with GABA powder? My original plan turned out to be a tad beyond my means (*cough*).

If I were to take some GABA, would it potentiate a GABA agonist active in the CNS by displacing the drug from somatic receptors, making said drug more likely to end up in the brain?
 
concerta gels up when i try to bang it. i end up just eating the goo, but i know how good it feels to shoot a ritalin... how do i cook it down?
 
concerta gels up when i try to bang it. i end up just eating the goo, but i know how good it feels to shoot a ritalin... how do i cook it down?
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You don't shoot concertas. They'll destroy your veins.
 
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