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The Large and Nifty Not-quite-advanced Drug Chemistry, Pharmacology and More Thread

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So are they hard to synth or not:?

Mescaline is not too easily metabolized and I dont think 3-methoxy 4,5-methylenedioxy phenylethylamine is.
 
I just gave you the one synthesis.

Lophophine and mescaline are both fairly easily metabolized, which is why the large doses are necessary for their activity (if lophophine is indeed even active). Mescaline probably requires such a high dose to saturate whatever enzyme degrades it.
 
I guess that they were too hard for him to make. I think that you have to find an essential oil with the same substitution pattern on the benzene ring?
 
We can say quite certainly that he didn't leave something out because they were too much work.

1. You start including much more and just the PEAs need to come out in a multi volume collection.

2. Many just aren't that interesting. The difference between the amphetamines and the PEAs is notable, but we're talking degrees of difference, not worlds.

3. Mescaline is definitely easily metabolised. You don't need 2-500mg to get a dose just because it's not very potent. If it weren't the TMAs would be really weak too.
 
Methyl-1-Etiocholenolol-Epietiocholanolone
can anyone break this down for me I have no chem back ground

Thanks
Bad News
 
I forget if I asked in this venue, but why might propylhexedrine have visuals for some people (above and beyond visuals induced by straightforward amphetamines, for those susceptible)?

There appears to have been no research on receptor-affinities...well, obvious adrenergic agonism is there. . . The cyclohexane ring would be wacky enough to preclude 5ht2a agonism, right?

ebola
 
2,5-dimethoxy 4-something N-desmethyl propylhexedrine?
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Won't work, aromatic ring is required for 5ht2a binding.

Offtopic, does anyone know if either 4-chloro phenethylamine or 3,4-dichloro phenethylamine is active?
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No idea. Could be, but the 4-chloro might be neurotoxic.
 
Some of my friends that use heroin say that when smoking off aluminum foil, you must:
A) use the dull side to smoke off of, because the shiny side has chemicals on it,
and
B) you must "preheat" the shiny side to burn off the chemicals

I'm 99% sure this is just junky folklore, but does anyone know if commercially produced aluminum foil might have any added chemicals that might be harmful when vaporized? I know the aluminum itself doesn't pose any threat, but maybe they coat it with something that is harmful?
 
shibireru said:
What are some readily obtainable substances which can produce death quickly, painlessly, and reliably?

Difficulty: No helium, carbon monoxide, nitrogen, nitrous oxide, or other inert gas.

P.S. I recently discovered that the handgun that I was planning to use if ever my hope should be exhausted was locked up. The cathartic feeling of safety and control that it produced to know that I could use that gun to kill myself is now gone and I'm feeling claustrophobic. I don't plan on killing myself right now, I just want these feelings of fear and worry over what travails the future has in store for me to abate; there's nothing worse than being trapped / cornered / helpless / stuck between a rock and a hard place.
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Watched a documentary once about LSD, think it was The Beyond Within (could be wrong) and the guy had cancer or something at the end and he had his wife IV 200mg of LSD into him in 2 doses to end himself, always figured that would be a good way to go if need be 8)
 
Yeah, excepting F, the 4-halo PEA's aren't good (and excepting 2,5 and probably 3,5 dimethoxy. lots of other substitutions that may or may not be safe, but it's an area that I'd be wary about).

Actually, I would like to see 4-fluoro phenethylamine. It probably wouldn't be active without an MAOI, I liked 4-FA, so maybe this would be good.
 
I'm kinda interested in 3-methoxy-4-chloro-amphetamine, and why not the PEA as well... anyone know if it's ever been assayed?
 
knowledge is power

Hey for all those people who are VERY knowledgable in the field of basic pharmacology and advanced pharm.......could you please shed some light on acronyms and the theory of both basic and advanced for I want to become a pharmacist down the road and already have a basic knowledge for chem and pharmacology.......I know its kind of broad...but I guess what I am asking is what drugs do what for what and how drugs help people in the big scheme...how they are absorbed distributed, metabolized, and excreted.
 
optimum000 said:
Hey for all those people who are VERY knowledgable in the field of basic pharmacology and advanced pharm.......could you please shed some light on acronyms and the theory of both basic and advanced for I want to become a pharmacist down the road and already have a basic knowledge for chem and pharmacology.......I know its kind of broad...but I guess what I am asking is what drugs do what for what and how drugs help people in the big scheme...how they are absorbed distributed, metabolized, and excreted.
Click to expand...

You may like The Color Atlas of Pharmacology. The torrent is widely available.
 
im sure most of you are familiar with the ORAC scale, i only see it used to evaluate the antioxidant activity of different fruits, vegetables, legumes etc. does anyone know of an ORAC chart with a comparison of the common pharmaceutical antioxidants like ALA, COQ10, idebanone, n-acetyl-carnatine, n-acetyl-cystine etc?
many of them are referred to as "potent antioxidants" but i would like a way to objectively compare their strength relative to one another and to various fruits...
 
hamhurricane said:
im sure most of you are familiar with the ORAC scale, i only see it used to evaluate the antioxidant activity of different fruits, vegetables, legumes etc. does anyone know of an ORAC chart with a comparison of the common pharmaceutical antioxidants like ALA, COQ10, idebanone, n-acetyl-carnatine, n-acetyl-cystine etc?
many of them are referred to as "potent antioxidants" but i would like a way to objectively compare their strength relative to one another and to various fruits...
Click to expand...

I'd look in one of the forums of the IMMORTALITY INSTITUTE (although a half hour lurking there may make you wish for death).
 
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