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The Large and Nifty Not-quite-advanced Drug Chemistry, Pharmacology and More Thread

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... said:
I don't think racemic tartaric acid will lead to anything but a racemic mixture.
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That should be a given, you should be able to figure out which to use...

The CAS number (3994-11-4) specifies dextrotartaric acid for d-AMP in a (1:2) proportion
 
Ether substitute (as a solvent)

Hello,

I've been trying to do some research around what solvents would be the best substitute for ether as a solvent with the following properties.

Would Cyclopentyl methyl work?

Appreciate any help.
 
Do you mean methylcyclopentane? If so I guess it would work as a non polar solvent. Otherwise pentane would also be suitable. But the best choice of solvent depends on what you want to dissolve :)
 
Thanks,

This would be to dissolve coca paste. I understand that the critical factors for a non-polar solvent substitute are:

a) Solubility of coke base
b) Miscibility with acetone +hci
c) insolubility of cocaine hci in the combined mixture of the ether substitute acetone/hci
 
Some simple alkane would maybe do the trick. Hell, they use gasoline in Latin America for extraction of the freebase :)
 
I Eat Pho said:
Is Chloroform not watched? I thought it was.
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It may be, but as I understand, it is also quite easy/cheap to synthesize yourself. Correct me if I'm wrong, I just remember a friend of mine wanting to do it for kicks and he had no formal chemistry training over the high-school level. He was extremely knowledgeable though. His dad did own some pretty nifty machines, so perhaps he intended to use one of those, which would make the synthesis dependent on having access to expensive equipment...
 
This is correct, there is an article on Erowid about its facile synthesis... It works very well for many but not all alkaloids and has a low boiling point so it dries very quickly (in fact, you can boil it on a hot plate in a hood if you like to dry off your product, so long as the product doesn't decay at 60C).
 
I was thinking about The Ryan Haight Act and Brett's Law and wondering if anyone can think of other laws that were enacted because of the death of a teenager? I know OpWebT was largely the result of some teen overdoses but what about in the more distant past...can anyone think of examples?
 
has it been established that mdpv is mostly dopaminergic? at least two people agreed with that in the eadd mdpv thread, but many others have said there is far more adrenalin than dopamine in the mdpv experience, and that goes in line with my experience as well.
 
vortex30 said:
It may be, but as I understand, it is also quite easy/cheap to synthesize yourself. Correct me if I'm wrong, I just remember a friend of mine wanting to do it for kicks and he had no formal chemistry training over the high-school level. He was extremely knowledgeable though. His dad did own some pretty nifty machines, so perhaps he intended to use one of those, which would make the synthesis dependent on having access to expensive equipment...
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Halogenation of an alkane is one of the first reactions you tend to see a mechanism for in a college Organic I lecture, and there's a really good reason why. You start simple.
 
How do chemists discover drugs that are unrelated to a natural lead compound? How did, for instance, PCP or pethidine come to be created, and how was it deduced that they might be pharmacologically active? I'd just like to know how any drug is invented in a "revolutionary", rather than "evolutionary" way, without being based on SAR or rational design or anything.
 
Yerg said:
How do chemists discover drugs that are unrelated to a natural lead compound? How did, for instance, PCP or pethidine come to be created, and how was it deduced that they might be pharmacologically active? I'd just like to know how any drug is invented in a "revolutionary", rather than "evolutionary" way, without being based on SAR or rational design or anything.
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Lednicer explains the genealogy of both in volume I (pages 56 and 299). Both were engendered by SAR.

As for pure serendipity: the story of LSD is well known, as is that of penicillin.
 
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