I knew about octopamine in August of 2000.
At that time, all of the human studies (and there were very few) showed beta 3's not to work (the rat studies were great though). In addition, an in vitro study specifically with octopamine did not produce results in human adipose tissue (though, it was great in rats).
I also asked Elzi Volk, who has done more research on the adrenergic system than anyone in the bodybuilding world, and also communicates with a lot of researchers, and it was her opinion that they would not do anything in humans. She already knew about octopamine at that time, BTW.
However, there was a recent human study with a beta 3 that showed it to be somewhat effective, so WTF knows.
The important thing is that all rat data on beta 3's and fat loss/lipolysis is MEANINGLESS, as humans and rats have very different adrenergic systems. And, you can guarantee they will toss rat studies out as evidence, just as they did with norephedrine.