Kratom and Bupe experiment
Hello all....
So my friend Roy used to have a pretty nasty Oxy habit that he couldn't kick for varying reasons (willpower being high on the list)... Long story short, Roy has been stable on 8mg of generic Buprenorphine (Subutex) twice daily for almost two years now. However 15 days ago, Roy rode his motorcycle home from work with his backpack on and upon getting back, was shocked to find two of his three prescriptions left in his backpack. Roy started to freak out but had always read that Bupe withdrawl was comparatively milder than other, full-agonist withdrawals, but more long-lasting.
He went completely clean for four days with very mild symptoms and started to feel pretty confident and even considered a rapid taper on his next doctor visit, though he has nerve problems which have always put that idea in the trash can after a period of time. But at seven days, he began getting hot flashes and sweats, shakes, diarrhea, lethargy, and his extremities began to feel like they were on fire to the point that he was getting one or two hours of sleep a night if he was lucky.
He remembered how he used to take Kratom to get him through when he was unable to find anything else, so feeling helpless, he grabbed some. It's doing the trick for him alright, though it feels much stronger than he remembers, surprisingly enough. He has his doctor's appointment in two days where he'll receive his prescription to pull him out of this quandary, but is wondering if Kratom and Bupe will have any synergy or if Bupe won't share its bed with another.... He's found tons of info and knows the chemistry quite well, but has found a baffling lack of personal experience. For those who don't know, Bupe binds VERY strongly to certain receptors and has a rude habit of kicking everyone else out of the house...it acts as both an agonist and antagonist...and has exponentially reduced effects with even minor dosage increases. Sometimes 4mg will work better than 8mg even, though this doesn't seem to be true for everyone and length of treatment seems to play a factor.
He has read that Bupe and Tramadol, for example, should not synergize but from his personal experience a few years ago, found that to be quite untrue and that the two compliment eachother very well actually and seem to have zero interaction. He's going to end the fling soon, as to not develop another habit, but would like to answer this question, if only for himself....
Though he's really curious as to whether this experiment has *actually* been done before and not just theorized. Roy says thanks!