EarthBounded
Bluelighter
- Joined
- Mar 2, 2013
- Messages
- 992
I'm not arguing with you, however you mods will take things to the grave.... So in that case we can all learn ( like usual )
You fail to mention any Yohimbine alkaloids, I am not saying this is a panacea ( solution ) and I have no idea the content of Yohimbine alkaloids in Mitragyna Speciosa however it is tiny things like this that may " throw off " a possible long term addiction.
http://www.ncbi.nlm.nih.gov/pubmed/2057541 <---- good read regardless
Kratom has seen therapeutic use in Thai ethnomedicine as an antidiarrhoeal, as a treatment for opioid dependence, and rarely to increase the duration of coitus.[21][22][23]
Kratom and its derivatives have been used as a substitute for opium as well as an aid for the management of opium withdrawal. - Wikipedia Mitragyna Speciosa
"The pharmacological effects of kratom on humans, including its efficacy and safety, are not well-studied"<---- Wikipedia Mtragyna Speciosa
This statement only refer's to the μ-opiod receptors, so YES I agree. HOWEVER these are not the only receptor's being contacted by the plant. I am simply stating we do not know enough.
Personally I do not believe that Kratom can Treat opiate / opioid dependency, that is a tad bit ludacris. But I stand firm IMO that some of the other compounds inside Mitragyna Speciosa MAY HELP PREVENT a human from becoming addicted to the herb, It's a cocktail of alkaloids.
I will leave it at this
The pharmacological effects of kratom on humans are not well studied. <----- Wikipedia Mtragyna Speciosa
Therefore we should all be cautious.
AGAIN SEIKO:
I just thought your initial comment sounded as if Heroin and Kratom have the same safety profile, I just did not want there to be any lack of information present if someone were to just scroll across this thread.
EB
The major alkaloid in almost every strain of kratom is mitragynine, and there are perhaps 5 or 6 other common ones present in pharmacologically relevant concentrations. There's speciogynine (an isomer of mitragynine), rhynchophylline (NMDA antagonist), dehydro-mitragynine, etc. None of them are miracle panaceas, and even then, I can tell you that straight up kratom alkaloid extract will produce dependence in mouse, rat, dog, chimps, and humans. So there's nothing to suggest that there is a mystery miracle alkaloid that makes kratom non-addictive.
You fail to mention any Yohimbine alkaloids, I am not saying this is a panacea ( solution ) and I have no idea the content of Yohimbine alkaloids in Mitragyna Speciosa however it is tiny things like this that may " throw off " a possible long term addiction.
http://www.ncbi.nlm.nih.gov/pubmed/2057541 <---- good read regardless
Kratom has seen therapeutic use in Thai ethnomedicine as an antidiarrhoeal, as a treatment for opioid dependence, and rarely to increase the duration of coitus.[21][22][23]
Kratom and its derivatives have been used as a substitute for opium as well as an aid for the management of opium withdrawal. - Wikipedia Mitragyna Speciosa
It's been known to Western researchers in the literature since at least the late 80s and has been distributed on-line from the mid-2000s onwards, so we're coming up to about 10 years of "street" usage now. It's not an unknown compound. I'm pretty confident in saying that kratom is addictive.
"The pharmacological effects of kratom on humans, including its efficacy and safety, are not well-studied"<---- Wikipedia Mtragyna Speciosa
I imagine if you go through 100gm a day of the stuff, yeah. The dose matters and the frequency of use matters, obviously. If you snorted 10 milligrams of heroin once a month would you get dependent? Probably not. 10mg once every hour? Yeah.
This statement only refer's to the μ-opiod receptors, so YES I agree. HOWEVER these are not the only receptor's being contacted by the plant. I am simply stating we do not know enough.
Personally I do not believe that Kratom can Treat opiate / opioid dependency, that is a tad bit ludacris. But I stand firm IMO that some of the other compounds inside Mitragyna Speciosa MAY HELP PREVENT a human from becoming addicted to the herb, It's a cocktail of alkaloids.
I will leave it at this
The pharmacological effects of kratom on humans are not well studied. <----- Wikipedia Mtragyna Speciosa
Therefore we should all be cautious.
AGAIN SEIKO:
I just thought your initial comment sounded as if Heroin and Kratom have the same safety profile, I just did not want there to be any lack of information present if someone were to just scroll across this thread.
EB