^Everyone's different, and you should only do what you feel is right for you. The long duration is one of the main plus points for me (no poxy re-dosing needed), but i just love the effect. I do prefer to dose early though - i found that if i do it before three pm i can just about get a little sleep before the next day starts (about 4 or 5 am) - if i take it later and try and stay up till the next night i usually get a headache. I prefer to stay up late though (gives me extra hours to work/play in) - If you want to sleep earlier than this though, take it earlier.
This feels like a tryptamine to me in the body- i suppose some people may interpret that body feeling as illness, flu-like or lethargic. I still haven't got nausea yet, just the odd stomach grumble (always on empty stomach).
Has anyone else noticed a long after-effect - like 5 days after, smiling and laughing more than normal (or is it just me?)