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Bluelighter
Welcome to the Big & Dandy Syrian Rue / Harmala MAOI alkaloids Thread



Harmaline -------------- Syrian Rue seeds -------------- Harmine

FAQ said:Q: What are MAOI's ?
A: MAO or MonoAmine Oxidase is a kind of enzyme in your body that metabolizes serotonin, norepinephrine and dopamine - all neurotransmitters acting in your nervous system that are of the class monoamines. By inhibiting
these, MAOIs increase levels of those neurotransmitters.
Quite a number of drugs can act the way they do because they resemble neurotransmitters in your body. They get involved in the household of these messenger chemicals and change the messages that are being sent in your brain. For example tryptamines such as DMT resemble serotonin and phenethylamines such as mescaline resemble dopamine (yet mescaline interacts with serotonin systems of the brain).
MAO enzymes are used by the body to break down drugs like DMT, if you take MAOI (MAO inhibitors or MAO blockers), you prevent your body from breaking down the drugs properly and this amplifies / potentiates the effects of the drug since there is more of the drug to remain in action.
In the case of DMT, MAO enzymes are so proficient at breaking down the drug that you can't even get DMT to work if you just eat it. However by first impairing these defense mechanisms in your body, you can make DMT orally active so that it can be eaten or imbibed via a brew. Certain brews that combine DMT and MAOI compounds are called ayahuasca which has been used by shamans in the Amazonian rainforest for ages.
Q: What is Syrian Rue ?
A: Syrian Rue (Peganum Harmala) is a plant that has seeds which contain beta-carboline chemicals which act as MAO inhibitors. It is an example of a relatively commonly used source of MAO inhibitors and it can have subtle effects of its own. It can also cause some nausea. Note that there exist also pharmaceuticals that can act as MAOI's which may have less psychoactive effects of their own and also less nausea. Moclobemide (Aurorix) is an example of this. However this choice is obviously not traditional like ayahuasca and its ingredients. Pharmaceutical based combinations of DMT and MAOI's are sometimes referred to as 'pharmahuasca'.
Warning: because MAOI / MAO Inhibitors weaken the body's defense mechanisms it can be dangerous to ingest certain foods or recreational drugs such as MDMA (ecstasy). You can read below what needs to be avoided to prevent potentially life-threatening interactions / accidents from happening!
External Information Links:
- Interactions Between MAOIs, SSRIs, and Recreational Drugs
- Basic MAOI Info
- Common Side Effects with MAOIs
- Foods to Avoid with MAOIs
- Drugs to Avoid with MAOIs
- The Interactions between Hallucinogens and Antidepressants
- Notes on Food & Drug Interactions with MAOIs

I've read from a few different sources about yage / telepathine conferring "telepathic" powers onto it's users... here, an example:
John Balance says "Telepathine is one of the constituent compounds of Yage... I think Telepathine was one of the first to be identified as being present in the brew and as one of Yage's powers is to bestow telepathy on participants thats how it got its name."
William Burroughs and Allen Ginsberg were so interested in telepathine that they hacked thru South American jungles a-way back to experience yage first hand... unfortunately, I've never been able to read IF they experienced "telepathy" or not...
Now, I'm pretty sure that it doesn't REALLY bestow telepathy upon the user, but my question is: has anybody using yage / ahauasca / harmaline / DMT had any experiences that would lead them to describe the effects of the drug as being "telepathic"?
Now that salvia is illegal in Australia, I've considered trying to do a DMT extraction and see what it's like, especially if such 'powers' (imagined or otherwise) were part of the trip.
Any feedback would be great. Thanks for taking the time to read.

For some user's info on several tryptamines when combined with MAOI:
I wouldn't be surprised if no one has tried this. Thus, it may be dangerous, or may not be. Here is what we know if I remember right:
DMT + MAOI = Activates it orally, roughly double potency and length snorted and smoked.
MET + MAOI = Similar to above (increases potency orally as oppose to activates)
DiPT + MAOI = ?
DPT + MAOI = Similar to MET + MAOI
5-MeO-DMT + MAOI = Very dangerous, probably responsible for one death (http://www.erowid.org/chemicals/5meo_dmt/5meo_dmt_health.shtml)
5-MeO-DiPT + MAOI = Increased body load, maybe dangerous? The person definitely took way too much (http://www.erowid.org/experiences/exp.php?ID=24026)
5-MeO-MiPT + MAOI = Large body load even on low dose, could be dangerous. (http://www.erowid.org/experiences/exp.php?ID=24026)
4-AcO/HO-DMT + MAOI = Ayahuasca like and intense, probably not dangerous but mentally trying? (http://www.erowid.org/experiences/exp.php?ID=58480)
4-AcO/HO-MiPT + MAOI = Unknown AFAIK.
So, my guess would be that MiPT + MAOI would be safe, make it more intense, double potency, lengthen the duration of action, and increase the body load. That is only a guess though. It may be very dangerous, so be careful. Hope this helps.
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