The Big & Dandy Synthetic Cannabinoids Thread

[Bella Figura]

Read the BL RULES!

edit - to stay on topic, I've had a yellowish batch of the jwh-073 and yes I could smoke lots of it in an evening. I've also had the white jwh-018 and that was definitely stronger and not something I'd want to do in excess at all.

I believe snorting them is a waste as well yeah.

 

[Volcano]

I've yet to try any 'pure' JWH compound, except for one hit one time of a 'Spice' product out of a glass spoon.

My question is, I own a Volcano Vaporizer, are any of you using this unit and if so how are you administering the JWH through the vaporizer? Are you using the "liquid pad" for hash or are you simply sprinkling the JWH over some fresh marijuana?

I also understand that one (-018/-073) is more carcinogenic than the other but cannot remember which, can someone spark my memory?

Thanks!

 

[Coolio]

I also understand that one (-018/-073) is more carcinogenic than the other but cannot remember which, can someone spark my memory?

You must be confused then, as there's no evidence that either is carcinogenic.

 

[Recept]

These two compounds are very similar, chances are that if one of them is carcinogenic then the other one is as well (due to metabilites). But it is correct - there is currently no evidence to support that theory as of yet.

 

[Volcano]

You must be confused then, as there's no evidence that either is carcinogenic.

Must be. I swear I had read something, at some point, on one of the JWH compounds (or perhaps a Spice blend) that was carcinogenic. My apologies. That's ACTUALLY what was preventing me some trying some out, so with that said, I may try some soon.

 

[Recept]

It is true that they may be carcinogenic because they contain the naphtalene ring structure which might result in metabolites called epoxides which could cause cancer in lung tissue over long time use. However, these carcinogenic metabolites have so far only been shown to be the result of administering these compounds to rats, and for all we know human metabolism might be entirely different altogether.

That said, even if these compounds turn out to be carcinogenic in humans as well, there is really no harm in simply trying them out (with regards to carcinogenic potential at least), and if used in moderation they are probably not that dangerous either. Cigarettes are also long known to be carcinogenic, but no-one has ever caught cancer from a single cigarette AFAIK.

That is not to say that using these substances is safe by any means. These are still relatively new compounds that have no long term history of use, so heed with caution as with any unreasearched chemicals.

 

[Delsyd]

smoking pot is carcinogenic too...

be wise with what you do and you;ll be fine.

 

[Recept]

^ Well yes, in that any pyrolized plant matter you inhale can be carcinogenic/damaging to the lungs.. However, cannabis (actually one of the alkaloids contained in it, I forget which one) is something that has actually been shown to be anti-carcinogenic, which is probably the reason there has been no correlation discovered between cronic marijuana use and lung cancer.

In case of JWH-018 (and other naphtalene-containing cannabinoids), however, the potential carcinogenic properties have nothing to do with ROA. The danger lies with the naphtalene epoxides that might be released in the process of metabolization of these compounds.

 

[Coolio]

It seems that CB1 and CB2 agonism and the resulting indirect cascade of hormonal effects may protect against cancer more than anything in cannabis smoke or JWH-018 metabolism intermediates could do to overcome the protective effects. If I'm not mistaken, the naphthalene epoxide metabolism theory you're referring to results in the presence of the epoxide for microseconds or milliseconds, not the release or accumulation of it throughout cells or the blood. A number of the synthetic cannabinoids have been found to have an antitumor effect, in addition to the natural cannabinoids.

Example:
http://www.jbc.org/cgi/content/abstract/M603495200v1

 

[bpayne]

I can't find any chronic anywhere so your telling me I can order a powder that has the same or more potent effect? is it really comparable to good weed?

 

[Coolio]

It's simply a different but similar effect. The comparison you're trying to make would be more similar to a comparison like opium vs. fentanyl.

 

[Recept]

From my experience so far (with a couple of different Spice blends), the effects are very similar to cannabis indeed, although I have found something to be missing that I can't quite put my finger on yet. They seem to be capable of producing most (if not all) of the effects of cannabis, but usually not all at once. Cannabis high seems richer in that aspect. That might mostly be psychological though, in that I have placed weed on a pedestal over the years of romance I've had with it and nothing can quite manage to be up to standard. I've observed similar phenomenon with mushrooms and synthetic 4-substituted tryptamines.

As a substitute for weed (in case you can't get any quality stuff or are looking for a more economical alternative) they do the job quite well though. Definitely worth a try.

 

[theotherside]

Ok so how do I properly store Jwh-018/073? I keep them in a tight bag in the fridge's butter section. How long do they have before they degrade?

 

[Delta-9-THC]

I wouldn't keep it in a plastic bag. They aren't completely airtight. It would probably be better of in a glass jar in the freezer.

 

[Xorkoth]

Not in my experience. I've had various batches of about 8-9 different cannabinoids that i am aware of, not counting regular cannabis which seems to outlast my willingness to smoke it anway. hehe :D

Is it possible you just used it a lot and your tolerance skyrocketed?

 

[Shambles]

Ok so how do I properly store Jwh-018/073? I keep them in a tight bag in the fridge's butter section. How long do they have before they degrade?

I've never bothered storing my JWH (018 and 073) in any special way. Had them both for months just in a standard sealy baggie lying around on my desk at room temperature. No loss of potency or any kind of degradation so far and it's been quite a few months now - seem to be very stable substances

 

[bubbly nubs]

A monkey had bought and tried a 100mg sample of jwh-018 and his came as a small solid rock, like a small button. It was slightly off white (a little yellow). After reading a lot of reports I have yet to see one about it coming as a solid chunk, not a powder. The monkey enjoyed the chemical but is ever so slightly dubious about it as he would like to buy a few grams and wants to make sure that he is buying wisely.

 

[Coolio]

bubbly nubs, it's just impure. You're probably looking at greater than 90% purity, but just the tiniest bit of this unknown impurity in JWH-018 causes it to change from a fluffy white powder into a hard, dense yellow/red/brown rocky substance.

Many batches from different chemists have led to different levels of purity, but most have been impure enough to turn yellow and hard. IIRC, even the guy who invented this chemical, Dr. Huffman, thought it was supposed to be a yellow oil and not a white crystalline powder when in pure form.

 

[bubbly nubs]

Oh bugger. It was very much more white than yellow, just a slight tint of yellow in fact. Probably best to try another supplier then

 

[Coolio]

Well, white is good. I've only found one batch of JWH-018 which was certainly of high purity, it was completely white and not at all dense. I can't find the quote from him now, but if he did say it was supposed to be a yellow oil, he never even got it pure enough in his lab when he was studying it.