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The Big & Dandy Synthetic Cannabinoids Thread

Which synthetic cannabinoid do you like or prefer?

  • JWH-018

    Votes: 89 50.0%
  • JWH-073

    Votes: 30 16.9%
  • JWH-133

    Votes: 0 0.0%
  • JWH-200

    Votes: 2 1.1%
  • JWH-250

    Votes: 28 15.7%
  • CP-47,497

    Votes: 3 1.7%
  • CP-55,940

    Votes: 8 4.5%
  • HU-210

    Votes: 5 2.8%
  • HU-211

    Votes: 1 0.6%
  • WIN 55,212-2

    Votes: 7 3.9%
  • AM-2201

    Votes: 5 2.8%

  • Total voters
    178
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^JWH 200 is an aminoalkylindole that acts as a cannabinoid (CB) receptor ligand. It binds to the CB1 receptor with high-affinity (IC50 = 7.8-42 nM).1,2 The effects of JWH 200 in locomotor activity, tail-flick latency, hypothermia, and ring-immobility tests are comparable or superior to Δ9-THC or WIN-55,212.3 It potently inhibits the contraction of electrically-stimulated murine vas deferens (IC50 = 3.7-6.0 nM).4,5

Formal Name [1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl]-1-naphthalenyl-methanone
CAS Number 103610-04-4
Molecular Formula C25H24N2O2
Formula Weight 384.5
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C

This thread just materialized in minutes, genius.
 
I'm with Delsyd on this one.... I think with the new availability, reports are going to come streaming in. I was wondering if anyone here got one of those lucky free samples sent out...

Anyone have any info on these synthetics and drug tests...?
 
The JWH compounds make me nervous. They're essentially giant aromatic hydrocarbons with only 1 oxygen and 1 nitrogen atom in most cases. :\ Not exactly the most appealing compounds.

I was wondering if anyone here got one of those lucky free samples sent out...
Yes I recieved a 12mg sample of JWH-018 early this year. The experience was overall pleasent, but for the reasons metioned above I going to stay away from these compounds, at least until more is known about their pharmacology and toxicology. I'm much more fond of cannabis anyway. :)
 
^ i think he was talking about samples of jwh 200

in my case oxygens and nitrogens arent what make a drug appealing as im not much of a chemist.

Its the effects of the drug that turn me on.
And i find JWH's quite pleasant (though not as good as the real thing).

And untill i see more substantial evidence of the harm its doing ill probably continue to use it sparingly, as i do now.
 
JWH-018= all the negative sides of cannabis (to me at least). I much rather plain ole bud :) I've tried one of the CPxxxx whatever there name is; not impressed, but I was a hellishly heavy smoker then...
 
^ i think he was talking about samples of jwh 200
My mistake. When I got my sample it was quite some time ago.

Delsyd said:
in my case oxygens and nitrogens arent what make a drug appealing as im not much of a chemist.
I don't mean how it makes you feel, I mean that in some of the more common JWH compounds, there are very few spots on the molecule for the body to attack and start to break them down(O and N atoms mostly).
Someone correct me if I'm wrong here.
Delsyd said:
And untill i see more substantial evidence of the harm its doing ill probably continue to use it sparingly, as i do now.
Oh of course. :) I'm excited to see more data myself.
 
I think he is referring to the carcinogenic properties that are very likely with these compounds... and yes, I was referring to JWH-200 on those samples.

I'm intrigued with these synthetics as I am unable to smoke cannabis but VERY VERY rarely... and I truly love a good sativa high... I spent the last hour or so trying to do research... and from what I gather... JWH-018 is very sativa like with properties of psychedelics but is very dose responsive and causes anxiety (not good because I have an anxiety disorder). While JWH-073 seems more relaxing and indica like without the complete stoning and near no anxiety but requires a higher dose.

Is that even remotely accurate? Can someone please explain the differences or even describe the differences from oral and vaporized doses. I genuinely enjoy some chronic sativa and would really like to smoke more than once every few months.

Thanks.
 
JWH-018 and JWH-073 are far more likely to be effective at stopping tumor angiogenesis and shrinking tumors than causing any tumors.

Cannabinoid agonists are directly protective against cancers. Cannabinoid antagonists are now being shown to greatly increase cancer risk and literally cause tumors in test animals.
 
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