Nootropics The Big & Dandy Nootropics Thread (Stack 2)

[Xorkoth]

I tried semax recently, which I had heard wonderful things about, many days for about a month. It was definitely a bit more acute than other nootropics I've tried (except hydergine which is still my favorite though I haven't had it in a long time, probably 9 years). But not as much as I had expected. It definitely cleared my mind and improved my mood slightly, it was good to help recover after little sleep or drug use. I don't think I'll get more though as it's expensive and I didn't think it was worth the price.

I still have a bunch of sunifiram left. Of all the racetam/racerams I have tried, it's the most effective I think. It actually produces a noticeable physical stimulation and improves my mood a decent bit, and clears my mind, but I don't feel like taking it regularly would be particularly advisable.

I have also been using noopept, maybe every other day or so. It's effective too, mostly at helping me to multi-task and stay on focus. I definitely like it.

Sunifiram and noopept are extremely cheap when purchased as bulk powder so I will continue to use them as needed. I used to use a lot of nootropics, I took a stack daily, but for a few years I have been not using them much. It started to feel like not the greatest idea to take a bunch of chemicals every day.

I've been considering getting hydergine again, but it's quite expensive and has to be imported... but oh, it was nice. Made me feel a non-trippy sort of threshold lysergamide buzz throughout the day which resulted in clear thoughts, balanced mood, even euphoric at times, and a sense of contentment. Easier word recall, easier concept linking, easier multi-tasking. It felt very healthy. I've read that hydergine may help to regenerate your mitochondria, which, if true, means it has tremendous potential in preventing aging. Apparently Hofmann (who invented it) took it every day and that guy was so articulate and present up until he died at 102 years old.

 

[InterestingFACT]

I tried semax recently, which I had heard wonderful things about, many days for about a month. It was definitely a bit more acute than other nootropics I've tried (except hydergine which is still my favorite though I haven't had it in a long time, probably 9 years). But not as much as I had expected. It definitely cleared my mind and improved my mood slightly, it was good to help recover after little sleep or drug use. I don't think I'll get more though as it's expensive and I didn't think it was worth the price.

I still have a bunch of sunifiram left. Of all the racetam/racerams I have tried, it's the most effective I think. It actually produces a noticeable physical stimulation and improves my mood a decent bit, and clears my mind, but I don't feel like taking it regularly would be particularly advisable.

I have also been using noopept, maybe every other day or so. It's effective too, mostly at helping me to multi-task and stay on focus. I definitely like it.

Sunifiram and noopept are extremely cheap when purchased as bulk powder so I will continue to use them as needed. I used to use a lot of nootropics, I took a stack daily, but for a few years I have been not using them much. It started to feel like not the greatest idea to take a bunch of chemicals every day.

I've been considering getting hydergine again, but it's quite expensive and has to be imported... but oh, it was nice. Made me feel a non-trippy sort of threshold lysergamide buzz throughout the day which resulted in clear thoughts, balanced mood, even euphoric at times, and a sense of contentment. Easier word recall, easier concept linking, easier multi-tasking. It felt very healthy. I've read that hydergine may help to regenerate your mitochondria, which, if true, means it has tremendous potential in preventing aging. Apparently Hofmann (who invented it) took it every day and that guy was so articulate and present up until he died at 102 years old.

Look into N-Acetyl Semax. Also N-Acetyl Semax Amidate. AFAIK they're only sold by a particular site that you'll probably find if you google them.

Anyways, these are modifications to the semax peptide to increase its penetration of the blood-brain barrier. Apparently they have radically more obvious effects. Definitely on my list, though I haven't tried them yet.

There's also discussions of them on the nootropics subreddit, but I don't want to link to the threads because they contain very prominent links to the vendor.

 

[Incunabula]

I've been considering getting hydergine again, but it's quite expensive and has to be imported... but oh, it was nice. Made me feel a non-trippy sort of threshold lysergamide buzz throughout the day which resulted in clear thoughts, balanced mood, even euphoric at times, and a sense of contentment. Easier word recall, easier concept linking, easier multi-tasking. It felt very healthy. I've read that hydergine may help to regenerate your mitochondria, which, if true, means it has tremendous potential in preventing aging. Apparently Hofmann (who invented it) took it every day and that guy was so articulate and present up until he died at 102 years old.

You do make it sound very nice I just wish it wasn't so difficult to find.

 

[bebekbu]

...I used to use a lot of nootropics, I took a stack daily, but for a few years I have been not using them much. It started to feel like not the greatest idea to take a bunch of chemicals every day

When people present a long long list of different chemicals they take everyday, I always have a feeling that is cannot be right. Most of the nutrients and useful chemicals that our organisms need should be taken from a well-balanced diet, I believe. And then on top of that we can take a few additional substances. I would say up to 5 should be enough. But of course each person's needs might be different, and some people might have more acute conditions - then maybe it is justified.
I am not an expert in nootropics and myself have just a 3 years' experience, but still it seems to me unreasonable. Could someone explain it to me what the reasons are for taking more than 5 or 10 different substances a day? Isn't it just a kind of psychological 'addiction' or effect of creative marketing (often with unjustified claims) of these substances? It must be a great business for many companies, but are the effects really beneficial for us?

I've been considering getting hydergine again, but it's quite expensive and has to be imported... but oh, it was nice. Made me feel a non-trippy sort of threshold lysergamide buzz throughout the day which resulted in clear thoughts, balanced mood, even euphoric at times, and a sense of contentment. Easier word recall, easier concept linking, easier multi-tasking. It felt very healthy. I've read that hydergine may help to regenerate your mitochondria, which, if true, means it has tremendous potential in preventing aging. Apparently Hofmann (who invented it) took it every day and that guy was so articulate and present up until he died at 102 years old.

I've tried hydergine before, but it only resulted in a headache and strange feeling of an increased pressure in my head. Do you think Hydergine is just not for me or was it maybe of poor quality (I bought it in <snip>). I bought Hydergine thinking that I could replace my LSD micro-dosing which works perfectly for me. Yet Hydergine turned out to be a completely different thing for me - only bad effects, no positive ones. But this is me, for other people it probably works well.

As for Albert Hoffman, I've heard he micro-dosed LSD and he took Hydergine as well, but only periodically. I wonder how often he micro-dosed LSD.

 

[Yeetbeat]

Please remember no naming/linking to vendors guys

 

[Doldrugs]

And then on top of that we can take a few additional substances. I would say up to 5 should be enough.

Based on what? You are just pulling this out if your ass.

 

[bebekbu]

Please remember no naming/linking to vendors guys

Sorry, forgot about it.

Based on what? You are just pulling this out if your ass.

I am, but the specific number is not important. My real question is why do many people have stacks consisting of a list of 10 or 15 different substances they take everyday.
It seems to me that such practice may not be good for the liver, it may cause more side effects, it can make evaluation of the effects of particular substances difficult or almost impossible.

Does a good stack need to consist of so many chemicals? I understand some supplements are there just to support the main active ingredients or counteract possible side effects, but still it shocks me sometimes!

 

[Listening]

I agree with you, but basically no one knows. It may be that one of these chemicals on its own is toxic in some way. It maybe that two of them in combo are toxic. Or maybe they're all safe, even in combo. Maybe. Who knows. Give it another 50 years and maybe we'll know the answer to some of these questions, but honestly we probably won't even know then.

I would personally be weary of taking *anything* on a daily basis that has not been through controlled clinical testing for many many years. I totally understand people risking it: Half of me certainly wants to try since I love the idea of nootropics, but ultimately, I think it would be irresponsible (particularly as a parent, but perhaps in any case). Just my personal view of course: everyone has to make their own risk / benefit assessment, but I think some people too easily ignore the truth of the unknown risk involved.

 

[SONN]

hydergine is the tits it helped me get over depression a lot and it felt like it partially healed my damaged serotonin system and brought the magic back to certain drugs. Definitely going to take it for the next month or so in preparation for all the music festivals this summer!

 

[Incunabula]

I agree with you, but basically no one knows. It may be that one of these chemicals on its own is toxic in some way. It maybe that two of them in combo are toxic. Or maybe they're all safe, even in combo. Maybe. Who knows. Give it another 50 years and maybe we'll know the answer to some of these questions, but honestly we probably won't even know then.

I would personally be weary of taking *anything* on a daily basis that has not been through controlled clinical testing for many many years. I totally understand people risking it: Half of me certainly wants to try since I love the idea of nootropics, but ultimately, I think it would be irresponsible (particularly as a parent, but perhaps in any case). Just my personal view of course: everyone has to make their own risk / benefit assessment, but I think some people too easily ignore the truth of the unknown risk involved.

I totally agree, and I couldn't have said it better myself. It's actually why I think phenylpiracetam is the best nootropic ever, because it works with just one dose.

Edit:
This is pretty horrific reading for any one who's taken hydergine or nicergoline, it's making me think twice about taking it, anyway----->

http://www.ema.europa.eu/ema/index....ews_detail_001832.jsp&mid=WC0b01ac058004d5c1b

 

[Ekscentra]

If there's a 3rd iteration of this thread, I haven't noticed it, so I'll just leave this here:

I just recently purchased N-acetyl Semax Amidate in the form of a nasal spray. Anything more will be too cost-intensive for me at the moment, but I intend to move on to SubQ administration at a later point in time. Also purchased 500mg Unifiram, so I'll get a chance to test this one soon. I still have a decent amount of Coluracetam and PRL-8-53 left, so I'll be able to report on combinations at some point as well. My Methylene Blue will probably last me a lifetime, and it's now become one of my favorite nootropics. Reports to come within the next few weeks, hopefully.

 

[Ekscentra]

The first test run with NASA was a major success, even from day one! I can see this having major potential for a wide variety of applications.

I applied 300mcg to each nostril for a total of 600mcg. Within 10 minutes, something subtle but not quite so noticeable came off. Within 15 minutes, it was unmistakable. There's this sense of being fully present - it's not forceful, but one is hardly inclined to distraction on this stuff. I'd say it killed at least 70-80% of undesirable ADD symptoms. Where normally I might become stuck in my head, with NASA I remain fully in-the-moment.

While being driven back from an appointment, I felt I could remember the entire route on memory alone, so potentially a drastic improvement in spatial memory! I'll have some great opportunities to bring out this substance's potential in the coming weeks, but what I'm seeing so far puts it straight at the top of my list, perhaps tied with low-dose psychedelics.

I'm unsure if NASA would be suitable for creative applications, but this is the only potential disappointment I can see. I plan to do an unprecedentedly powerful stack in about a week - it'll be interesting to see just how far I can push this. The stack will include NASA, Unifiram, Coluracetam, PRL-8-53, Methylene Blue, and either D-Amphetamine IR or Phenylpiracetam Hydrazide, depending on what I have available. I may add Hydrafinil as well, but I think NASA has displaced the need for Modafinil and its analogues entirely.

 

[I B Profane]

Here's the stack I've started on for school.

R-Modafinil 50-200mg
Caffeine 100-300mg
L-Theanine 100-200mg
Noopept 10-20mg
Cod liver oil (omega 3, 6, 7, 9, EPA, DHA)
Ginko ~100mg
Ashwaghanda ~600mg
Multivitamin (with choline, and all the good stuff)

Also taking: Gabapentin 900mg/day for anxiety and mood stabilization, Nicotine (vaped, pretty frequently), Cannabis (usually just at night time) and .25mg Clonazolam (only at night for insomnia, anxiety and back pain.) I'm definitely digging this mix, I feel like the nootropics in the morning help with the memory issues that I get from benzos and weed. Ideally I'd like to taper down from the benzos and get on a sleeping med with fewer side effects (rebound anxiety, memory loss) and perhaps a muscle relaxer as well.

OT, does anyone know of a good nootropic for improving memory? I know they're all supposed to help with memory, but which one is the most effective in your opinion?

Also, I think this thread belongs in OD rather than PD, but eh.

 

[InterestingFACT]

First comment is that clonazolam is far too long-lasting a drug for nighttime use. Why aren't you on a shorter acting drug like etizolam?

Beyond that, is there a reason you need the benzo for sleep in the first place? You're not really on any hard stimulants you need to wind down from. Unless insomnia has been a lifelong problem for you it makes sense imo to just cut the benzo out and deal with the rebound.

I think noopept is about as good as it gets for (long term) memory, though it fucks with your short term memory a bit. You could also consider sunifiram... But tread carefully there because it has more potential consequences than the racetams or noopept. Also consider acetyl semax amidate--that's imo the most effective nootropic out there. Well, other than dihexa, but it's not really safe to encourage use of that one.

 

[MrHH]

I've recently heard about Hydergine, does anybody have any experience with it? It looks like it was extensively used by Albert Hoffman.

 

[dopamimetic]

Couldn't decide whether I should open a new thread in 'trip reports' but as it isn't really one, here we are ...

P21 - that peptide they modeled after cerebrolysin (well, something I'd never have administered.. extract from pig brains, but it's being said to be effective). I don't respond well to the racetams/cholinergics (tension, irritability and anxiety) and am unsure about the AMPAkines. Sunifiram felt good once, then overstimulating another time, and I very probably have some glutamate imbalance (suspected NMDA overactivity, but the matter is too complex for me yet- I'm taking 30mg of memantine daily which has robust mood-stabilizing and anxiolytic properties for me).

So I've tried SEMAX. Which is kind of a double edged sword. Better than the racetams, but with a rebound and hints of overexcitability / oversensitivity to stimuli. Then I finally decided to give P21 a try. I've diluted 25mg in a 20ml saline nasal spray. Being cautious because of the intensive effects SEMAX had, I initially thought it had no effect. Ok, one has to take it over some time before the effects manifest, so I've continued. Still nothing really noticeable.

Until yesterday evening. Honestly, I've just used the spray bottle to moisten my nose that has been dry due to a recent cold and occasional insufflation of powders. After 30 mins or so I've noticed that something is going on. I felt very, very calm, yet totally awake but not 'wired' at all.. together with an emerging clarity of mind and a distinct serotonergic feeling. I know one can't directly attribute feelings to neurotransmitters, but I'm quite experienced with drugs and I'd bet P21 raises serotonin synthesis.

Today I've continued with higher dosing (maybe 2-3mg?) and the effects did too. From time to time I'm noticing that 'HD vision' (and hearing) together with an unusually crisp clarity of mind. I haven't felt like this for a very long time, possibly even since I was a child at age of 12 or so (before the depression hit me, that is). I've used to take dopaminergic psychostimulants and/or dissociatives to bring a bit of this back, but it never was so clean, so natural, subtle, yet so strong at the same time. Even reminds me of the effects of 4,4'-dimethylaminorex (without all the stimulation and side effects of course).

Part of it might be placebo, and it's not representative. But the neurogenesis is real. I don't know yet if it is sustainable, but at the very least it showed me how much of locked power I have in my brain, and gives me hope to achieve a way to unleash it...

 

[immad]

How do you know it's neurogenesis and not just some receptor (de)activation?

 

[Incunabula]

I've recently heard about Hydergine, does anybody have any experience with it? It looks like it was extensively used by Albert Hoffman.

I guess you didn't see my post further up this page The European medicines agency is warning doctors to not use ergot derivatives like hydergine or nicergoline as a medicine, because they consider the risk of fibrosis too high - they simply don't consider it worth the risk based on the data they have. I really think hydergine should be discouraged as a nootropic. It does sound really nice though.

EMA: New restrictions on use of medicines containing ergot derivatives.

The European Medicines Agency’s Committee for Medicinal Products for Human Use opinion follows a review of available safety and efficacy data on ergot derivatives in the above indications, including clinical studies, post-marketing data in Europe and the published literature:

• Fibrosis was most frequently reported with dihydroergotamine, including retroperitoneal, cardiac, pulmonary and pleural fibrosis. There were fewer reports of fibrotic reactions with the other ergot derivatives. The CHMP noted the difficulty of diagnosing fibrosis (due to delayed onset of symptoms) and the probability of under-reporting of fibrotic reactions.
  
• Ergot derivatives are recognised as being capable of inducing fibrosis, in particular heart-valve fibrosis, through serotoninergic-receptor activation, which is extensively described in the literature. The varying affinity for serotoninergic receptors of the different ergot derivatives, and the therapeutic doses used, may explain the differences observed in reporting frequencies for the fibrotic reactions.

 

[Mracid]

Hi I recently tried some low dose of Legal 4-HO-MET with noopept in megadose added to Choline supplement. I found at first the combo really potent in intellectual comprehension potentiation specially social cues and environment understanding, goal achieving etc. So it got me thinking, could a low dose of psychedelic with a daily adjustment to tolerance be added to a nootropic cycle to make it more polyvalent, or even more potent.

In theory if the confusion isnt reached it could work, and personnal experiance point in that direction too but the only data I got is an observation and theoretical extrapolation, and sadly im not in position to make any experiments so I'd like some opinions on the credibility of my hypothesis.

 

[Thatmikepageguy]

@Bigshooter-
Nootropics are great but piracetam is weak. Try pramiracetam. Its a varient within the racetam family (like piracetam, oxyracetam, aniracetam, ect) that ive used and been very impressed.