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Nootropics The Big & Dandy Nootropics Thread (Stack 2)

Tianeptine is an antidepressant that also hits the mu opioid receptor, so it is in effect an opioid, at least in terms of what it's doing to you. It's also an SSRI, so if you use it regularly, it can lead to some nasty withdrawal. In fact a good friend of mine was taking large doses daily (in large doses it feels much more opiate-like), for a couple of months, and when she stopped she experienced horrendous withdrawals. She's been addicted to various opiates including heroin and she said it was the worst withdrawal she's felt.

Personally, I was addicted to opiates for 10 years, it almost destroyed my life. I got some tianeptine to experiment with a while back and after a couple of days I realized I was taking an opiate and I gave the rest away so it wouldn't tempt me.

I wouldn't call it a nootropic, it's much less benign in action. I'd call it an opioid antidepressant.
 
Xorkoth said:
Tianeptine is an antidepressant that also hits the mu opioid receptor, so it is in effect an opioid, at least in terms of what it's doing to you. It's also an SSRI, so if you use it regularly, it can lead to some nasty withdrawal. In fact a good friend of mine was taking large doses daily (in large doses it feels much more opiate-like), for a couple of months, and when she stopped she experienced horrendous withdrawals. She's been addicted to various opiates including heroin and she said it was the worst withdrawal she's felt.

Personally, I was addicted to opiates for 10 years, it almost destroyed my life. I got some tianeptine to experiment with a while back and after a couple of days I realized I was taking an opiate and I gave the rest away so it wouldn't tempt me.

I wouldn't call it a nootropic, it's much less benign in action. I'd call it an opioid antidepressant.
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It's actually not an SSRI (nor an SRE, as some people formerly claimed--it has no net impact on serotonergic activity)

It alters AMPA and NMDA activity--though It has no measurable affinity for any known binding site there. It also, like you mentioned, has significant mu opioid (and some delta opioid) affinity. It may simply bind at an unknown site in the glutamatergic system, but it's AMPA effects may even be a downstream effect of its peculiar interaction with mu-delta opioid heteromers--though I'm personally skeptical of that.
 
Mycophile said:
Thanks everyone.

I guess no one really know how long this stuff lasts in your system though huh??

No one knows its half life??


Anyways, sounds like a safe substance and it just arrived in the mail yesterday so I'll probably try it within the next week I'm guessing.

Since I take Klonopin 3-4 days a week I'm sure I'll try the combo eventually and report my findings.

Also, one other question, should I avoid taking it with Phenibut??

I just got some of that in the mail but I NEVER use it more than once a week, so avoiding the combo is easy, but if it could be a GOOD combo I'd like to try it.

Thanks
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Phenylpiracetam half life: 3-5 hours so basically effect last 6-10 and its stays in your body for 15 to 25.

Phenibut half life: bout twice as phenylpiracetam.

Combinations:
Phenylpiracetam/Phenibut is good but i prefer cycling them once a week on different days for different occasion but the combo is Present and euphoric.

Adding Kpin to Phenibut is appropriate for anxiety fighting without anything to do else than have fun.

Kpin and phenylpiracetam is ok for antianxiety but good for stress-less work/school.

Mixing 3 is the best in term of buzz but hard to use once a week, kinda addicting thing i tell you! I use flurazepam and oxazepam instead of Kpin but it dose the same. INTENSE anti-anxiety and great presence without memory problems.
 
Xorkoth said:
I actually find that -racetams combined with stimulants or empathogens seems to make the whole experience smoother and more satisfying, with less comedown. I wouldn't say it increases the stimulation. I haven't tried it with phenylpiracetam, but I have with piracetam and oxiracetam, and sunifiram.
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Funny I think the same but with Indole based psychedelics simple agonists. Smoother, more satisfying less comedown but definately longer buzz but i would say it does increase dopamine response to serotonin so its good to increase the less stimulating psychedelics's stimulating effect (ex: 4-HO-MiPT, 4-HO-dmt, etc.)

I tried Aniracetam(alone with choline and combo), noopept(alone and in combo), phenylpiracetam(in combo).

Big combo mode I use now when i take psychedelics: Aniracetam 2g , Centrophenoxine 500-750mg, Noopept 100mg, Theanine 200-300mg, L-DOPA 100mg, and phenylpiracetam 200-300mg. Along with B6 to help dopamine synthesis from L-DOPA.

The combo is stimulating alone so added to any psychedelics its bomb dynamite but with a neurogenesis explosion from BDNF and NGF (nerve genesis promoting proteins) with an euphoric shock wave along with incredible visuals and a clear head.
 
That describes its structure, not its function.

Tianeptine shares little in common with other tricyclic antidepressants.
 
No, it is a serotonin reuptake enhancer which shares little in common with SSRIs, and while being too complex to oversimplify seems closer to the opposite of an SSRI in terms of synaptic serotonin levels. But SSRIs seem to be a bit poorly understood afaik, as the effect does not seem to be to simply increase synaptic serotonin like a plain SRI. Tricyclic structure of tia does not seem that relevant like interestingfact suggested.

Antidepressant effects seem to be glutamatergic / via AMPA and effect on nerve generation which seems more similar to dissociative antidepressant effects. And also the opioid effects most likely contribute to the feeling of well-being.

Tianeptine seemed pretty interesting to me for a while and I considered ordering it, but I don't think that it would be a responsible or safe thing to do as I would probably not settle for therapeutic levels.
 
Of you people that tried more than one eugeroic, which one did you find most efficacious? And did any of them felt more dirty or nasty than the others?

Modanifil?
Adrafinil?
CRL-40,940? (aka bisfluoromodafinil, Flmodafinil, lauflumide)
CRL-40,941? (aka Fluorafinil, Fladrafinil)
hydrafinil (aka fluorenol)
or Modafiendz? (aka N-Me-4,4‘-difluoro-modafinil)
 
I B Profane said:
Is tianeptine considered a nootropic?
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I didn't find it to be nootropic, or even an effective anti-depressent.

Actually, I didn't even enjoy a recreational dose (100mg~), personally. It reminded me of GBL. I'm not sure I enjoy opiates.

I'm finding fasoracetam to be an effective anti-depressent. Cheers for the reccomend, InterestingFACT.

The sexual side effects of Rhodiola wore off, as did the more worthwhile effects, unfortunately. When that stuff works it feels like I've got tryptamine energy coursing through my veins.
 
I find that Noopept, 30mg 1-2x per day, is a very effective mental stimulant, without the central nervous side effects of caffeine and other common stimulants. I don't notice any headaches when taken without choline, as reported by some users, but I still supplement with 250mg CDP choline every third day just to be safe.

I have also noticed that Noopept, at a dose of 30-50mg, works very well for potentiating and altering the perceived effects of 4-AcO-DMT, DOC, and 1P-LSD.
 
@[deleted post]:We don't do sourcing here, friend. Even for legal stuff (with the exception of scales and needles, for the sake of harm reduction).

---

@Tranced: I'm glad the fasoracetam is working out for you. I noticed you sent me a PM about it way back that I never answered--I just consistently fail to notice when I get those, unfortunately. :p

May I ask how you would subjectively describe the effects of fasoracetam? Also, did it reduce your benzo tolerance like you hoped?

I got mine several months back in the same order with several other compounds, and was trailing tianeptine at the time. When I tried it (I'm not dependent on benzos) the fasoracetam honestly just made me narcoleptic: actually it induced a state I sometimes get on DOC--sort of just fading in and out of consciousness without knowing whether I'm awake or asleep, and "answering" in my head without actually saying anything when people talk to me.

.... So, it definitely wasn't a cognitive enhancer, in my experience. That being said, I'm fairly certain this was induced by the combination of tianeptine and fasoracetam: I already get kind of spacey/"dreamy" on tianeptine (and opioids in general) and would occasionally get similar effects after taking too much sunifiram (especially on the "come down") taking sunifiram for too many days in a row, taking sunifiram while sleep deprived, or taking it with too large a dose of stimulant or other nootropic. Both tianeptine and fasoracetam mess with AMPA signaling and so it doesn't particularly surprise me that the combination might cause similar side effects as more serious AMPA modulator like sunifiram.

Nonetheless, I quickly decided that, as a nootropic it wasn't worth my time when I have other, cheaper nootropics that I view as both more effective and safer. But it's stowed away as security against the eventuality that I one day might find myself dependent on benzos or some other GABA drug. Fortunately, I'm not an anxious person by nature, nor much of a "casual" drinker, so my sedative tolerance remains conveniently low.
 
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I need to invest in some racetams soon. I honestly don't know why I haven't ordered any yet... I feel like they would really benefit in terms of managing my depression and major anxiety.

Currently on a natural nootropic and adaptogen stack as of now:
L-theanine
Rhodiola Rosea
Phenibut
Caffeine
NAL-Tyrosine
ALA
Ginkgo Bilboa
DMAE bitrate (Choline)
Vinpocetine
Bacopa
DHA/Omega 3's
L-Glutamine
Krill Oil
Nicotine
Melatonin (nightly)
Valerian (usually nightly, unless I'm anxious)

Prescribed 8mg Subxone and 1200mg gabapetin daily. The gabapentin certainly helps with the GAD IME, although nowhere near my diazepam script that's long gone. Nor is melatonin any temazepam 30mg's, but the neuroprotective properties take the win.
 
If you can find some, I recommend hydergine for depression although I'm not sure how it will interact with some of those (probably fine but look into it). I was depressed and anxious after I moved across the country after graduating college (which was a culture shock for me and a difficult transition). I was also taking piracetam and centrophenoxine and I think some others, but when I added the hydergine it helped more than anything else, in my opinion it's one of the best nootropics. Not only did it help with depression and anxiety quite a bit, it also was quite nootropic in terms of increased mental function.

Phenibut is great also if you dose it right, I still use phenibut and not really any other nootropics (though I really don't consider it a nootropic). It's one of my favorite substances but be warned it produces physical dependence. I used it daily for a year and I withdrew rather hard for a week one time when I ran out and was broke and couldn't get any more. Now I take it every other day at most, even that slowly produces minor dependence but sometimes I go longer between doses and it solves that. Phenibut always makes me feel wonderful for a day, if I dose right (which is, for me, 1.5 grams with no tolerance, or up to 2.5 grams with tolerance). Too little and it doesn't do much, and too much it will produce an intense lethargy and joint soreness. It's kind of risky to take this way for depression because the draw is to use it daily since it works so well.
 
Xorkoth said:
If you can find some, I recommend hydergine for depression although I'm not sure how it will interact with some of those (probably fine but look into it). I was depressed and anxious after I moved across the country after graduating college (which was a culture shock for me and a difficult transition). I was also taking piracetam and centrophenoxine and I think some others, but when I added the hydergine it helped more than anything else, in my opinion it's one of the best nootropics. Not only did it help with depression and anxiety quite a bit, it also was quite nootropic in terms of increased mental function.

Phenibut is great also if you dose it right, I still use phenibut and not really any other nootropics (though I really don't consider it a nootropic). It's one of my favorite substances but be warned it produces physical dependence. I used it daily for a year and I withdrew rather hard for a week one time when I ran out and was broke and couldn't get any more. Now I take it every other day at most, even that slowly produces minor dependence but sometimes I go longer between doses and it solves that. Phenibut always makes me feel wonderful for a day, if I dose right (which is, for me, 1.5 grams with no tolerance, or up to 2.5 grams with tolerance). Too little and it doesn't do much, and too much it will produce an intense lethargy and joint soreness. It's kind of risky to take this way for depression because the draw is to use it daily since it works so well.
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After reading up on it and hear other's testimonials about the positive effects of hydergine (especially in terms of chronic depression and all that comes with that territory), I am now highly interested in this nootropic and have been reading up all the info on it I can find. Not to mention, LSD has done wonders in the past for my depression and spiritual health; considering the relation to hydergine I think it could really benefit me and possibly be life-changing. I wanna add some my stack (which is far shorter now) and am planning on ordering some tonight/tomorrow once I find a proper source that I trust.

I no longer plan on using Phenibut. It's desired effects are far outweighed by the negative effects IME. My joints and my lower back will start to hurt excruciatingly for some reason. It also has a uncomfortable effect on my body temperature. It was always too "hit or miss" for me, and in that case it was mostly a "miss". I'd rather just take pregabalin or the hordes of gabapentin I have at my house from previous scripts. I think the two previous mentioned gabapentoid scripts I listed basically ruined my changes of having a "sweet spot" with phenibut because my tolerance won't allow the more comfortable lower-end/moderate doses to do anything for me. Kinda a bummer for me. I've yet to try the beloved GHB or GBL, but I'm sure those would have much more in store for my enjoyment.
 
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Yeah the two weird effects from phenibut I get are sore joints and a lot of heat in my skin. I find that if I dose just right they don't manifest, but it's easy to dose just a little high. You really have to get the dose just right with phenibut. Anyway it's addictive so no harm in not using it.
 
Piracetam is good for memory and mental sharpness. Although some of the analogues are more effective. Ginkgo and ginseng are quite subtle, couldn't hurt but I never noticed anything beyond placebo. I find sunifiram to be a good energy and mind motivator, extremely potent too so a gram for example will last a long time. Noopept (a nootropic peptide) is also quite good.
 
Yeah, it's very good. (Piracetam)
When I had a concussion I couldn't focus on reading anymore, after a paragraph I already forgot what I've read, I was prescribed Piracetam because it helps with blood circulation in the brain.
It really worked wonders for me, I was reading Blavatsky's Secret Doctrine, which was quite hard on is own, with Piracetam it felt like my brain was completely switched on, every topic she touched I researched on my own as well, and every topic stuck with me.

I might try Sunifiram, but what I've read is that it's 1000 times more potent, I'm not sure about the side effects.
 
It's an ampakine, which is different though related. It has some bit of stimulation. Piracetam is almost surely safer but I find sunifiram to be a bit more effective. Piracetam is great though.
 
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