I usually insufflate it, occasionally sublingual. There is a definate loss of magic when used everyday but thats the thing about mxe, one day you'll have been redosing into the 200mgs mark going into the 300mg mark and you'll have nothing but the manic wacky stimulant like effects with slight oevs, wiggles, shifting and what not, everything nature and the like having a much prettier glow to it, while the next day or two the first 60mg line you do you slip right into a hole. One day you'll feel like you're chasing clouds then the next day bam you get what you've been looking for, with mxe it seems the holes just come out of no where provided the set and settings right, I think I had commented somewhere earlier in the thread when someone asked something, that mxe can be different every time. But yes there is a definate loss of magic after constant use, then its time to take a break, but over the past two years I've never been not able to recapture it with a 3 week/month break though I wouldnt really recomend the amounts used to people not as framiliar with it, but even when my tolerance has been at its highest even if a do a small 10-15mg bump I'll still get that little rush of euphoria and its anti depressant effects
As for the bowel cramps and stomach disturbances, I suppose every once and a while they may happen but nothing thats ever really bothered me or make me even really taken note of, I usually have a real strong appetite with it, but occasionally forget to eat much, I like to have peanut butter around for that. I actually get the urge to go take a shit during the first dose sometimes. The only thing I have to complain about in that department is that sometimes you get the "I have to pee...I cant pee" thing like you get a wave of unnessecery pee shyness when you're at the toilet for no reason.
Sleeping can be hard, but I've always had sleep problems, any given week use or no use there will be a day or two where I just cant sleep andI'm definatly a night owl. Another thing that varies with mxe is, yea sometimes the next day I feel very intoxicated while other days I'll wake up fresh as a daisy ready to take on the world without much of a difference in doseages.
While mxe by itself to me seems pretty benign, oddly enough weed of all things is what brings out those white knuckle "oh fuck" moments. I'm a pretty regular smoker, but while on mxe my tolerance drops 10 fold, dont get me wrong a small puff of weed here and there goes greatly with mxe, but if you smoke too much or the amount you're used to your heart rate and bp increase alot and I've never been one to get panic attacks just smoking weed. I've never mixed stims or phens with it but pretty much everything else I've done in combination with it has gelled pretty nicely.
But mentally I think back a couple years ago to before I'd ever tried mxe and minus a the few foggy manic days that quickly pass with long long binges I'm pretty much the exact same person I was before I'd tried it, just more open minded though that cant be attributed just to the mxe, other things have definatly played a factor. Dissociatives seem to bring out the best and worst in some people, like a love them or hate them type situation and I love them. But this is all just from my experience, I've read a few horror stories on here, walking off roofs, running around naked down the street ect..Thats why I've found mxe and K are best to do around people who are framiliar with them or by yourelf, and they definatly vibe better with the nightime.
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) and I really want to trip, but I'm going to a fest the week after so I don't want to have any lingering tolerance. So I decided on MXE, but at the same time I don't want to be too dissociated, because I want to be fully present to experience this show. 
