The Big & Dandy Methoxetamine Thread - 6th Dose (now you've gone and used it all up)

[InterzoneAgent]

^It sounds like MXE can potentially cause some dark experiences. Ketamine was never like that for me; my experiences were always mindblowing in a very good way. The only bad experience I had on it was because my tolerance had got to the point where I couldn't hole properly but I was stuck in an emotionless place where I could hear strange whispers coming out of the shadows. With MXE I have heard guitar music playing very realistcally, but it wasn't just playing in my head. It was like it was emanating from all the physcial matter around me - the floor, the toilet, my skin, everything. And it was also like because I could feel the music in me, that the vibrations melted me in to my surroundings. I know it sounds bonkers, but that is how it was.

Well i have had somewhat dark k-holes also, but as with ketamine & mxe the darkness doesn't matter when under the influence. With psychedelics this would certainly mean very, very uncomfortable time, but with dissociatives you, in a way, just don't give a fuck or don't know how to give a fuck, really. And that's how the innocent little loveaffair with them begins...

That above mentioned experience however, was unlike any previous trip i have ever had with any disssociatives nor other substances for that matter. I would bet the re-dosing and DRI-effects had something to do with it being so "sober" and psychotic? Any input on that?

 

[Survived Abortion]

Yes, that is really how it happens. When you are in that state you are too 'tranquilized' to care, no matter how crazy it gets. I did notice that with MXE I was still able to be somewhat amused and personally invested in what was going on, whereas with ketamine I am much more distant from the emotional ramifications.

Well i have had somewhat dark k-holes also, but as with ketamine & mxe the darkness doesn't matter when under the influence. With psychedelics this would certainly mean very, very uncomfortable time, but with dissociatives you, in a way, just don't give a fuck or don't know how to give a fuck, really. And that's how the innocent little loveaffair with them begins...

That above mentioned experience however, was unlike any previous trip i have ever had with any disssociatives nor other substances for that matter. I would bet the re-dosing and DRI-effects had something to do with it being so "sober" and psychotic? Any input on that?

You know, I found with ketamine that repeated doses, say three or more sub-hole or hole doses would always put me in to a very peculiar state of intoxication. The whole nature of the experience would change, and it would be as if I could shift in to a completely different state of being where I was ultra lucid and the normal physics of things would go out of the window.

This was distinct from a k-hole, where in the k-hole there is very little lucidity and presence. But in this extended state, I would be fully lucid to what was happening. I would be simultaneously observing and in charge. There would be enormous visual activity, especially with closed eyes where the space would be filled with colour. I could reach a state where I couldn't tell whether my eyes were open or closed, because it was the same thing. I would be able to swap bodies with a tripping partner, communicate with him/her telepathically, suspend the flow of time, jump through portals to other realities and such. I would regurgitate what seemed like computer cells, often feeling like I was some sort of highly advanced artificial life form trying to discover the nature of it's true being. Really crazy stuff that doesn't make any sense whatsoever to a sober person, but makes perfect sense in that state. During all of this I would be functional, and able to move about at will. The only thing I would have trouble with would be verbal communication.

I've read about the DXM plateau sigma, and some of the things about that state really remind me of it. I wonder if that is something all dissociatives share - the ability to enter the sigma plateau (or some analogue of it) - by repeated doses. And if that is the case, then the state you described with MXE could be pharmacologically similar to that produced by a similar dosing regimen with DXM or ketamine. You may be correct that it is increased cumulative DRI activity. I too would be interested to know. The patterns of dosing to get there need to be just right. It's like you need to redose while your coming down from the last hole, but your redoses don't neccessarily have to be 'hole' doses. By the time you get to that state, you are so lucid, you are not really holing, but you are not sober either. It's like being both at the same time.

 

[psood0nym]

psood0nym, how do feel after those orgasmic DXM/ondansetron and buprenorphine experiences?

I'll NSFW my response because it's only tangentially related to MXE:

NSFW:

There's no bad comedown whatsoever. I feel just like after a normal dissociative or opiate experience, which is to say a little foggy with a pleasant afterglow. The euphoria simply weakens until I reach baseline and stays there. When I first started using the DXM/ondansetron combo two summers ago, I used it maybe four times per week for maybe a month and a half (IIRC). I had posted about it on Bluelight when I first discovered it, but then deleted it and PM'd all the people who had quoted my post about it asking them to delete their quote of me because I was worried anyone who tried it would be hopelessly addicted (I've tried lots of highly addictive drugs, and nothing worried me like this). However, over the next few months I got a number of people to try the combo by supplying them the ingredients, and while they definitely experienced an interaction -- with all but one noting a significant drop in dissociation and increase in stimulated lucidity -- none had experienced the profound euphoria I did. Sorry if I got your hopes up... The only consequences from it were brain zaps, presumably from the DXM's SSRI effects (these zaps are what made me slow down with it). I originally stumbled across the combo because I was using 4 - 8 mg doses of ondansetron to avoid DXM nausea, and noticed all my DXM experiences were among the best I've ever had. When I took it without ondansetron it wasn't nearly as good. So I tried doubling my ondansetron dose and voila.

The DXM/ondansetron gave me the best raw quantity of intensity of euphoria I've experienced, and adding buprenorphine to the mix (and to a lesser extent, MXE), makes the euphoria just cartoonish and hard to believe, but there it is. It's like its working not through massive serotonin or dopamine release, but through targeting just the right sweet spot. I have no idea why selective 5-HT3 antagonism should do anything in conjunction with DXM. I thought it had to do with the SSRI effects, but I've tried ondansetron with proper serotonin releasers to test it without the effect, so I don't think it's just excess serotonin in combination with 5-HT3 antagonism that's responsible. The DXM combo will work day after day (though I've never gone more than four days in a row because I don't like the idea of dissociative over use). The most common side effect is that my teeth start to chatter during the surges of euphoria (not jaw clenching, but teeth chattering) which doesn't happen with DXM alone. I also get leg muscle spasms. I think it has something to do with serotonin, but there's no depleted serotonin effects in the days after (other than the brain zaps, but that's only after extended periods of overuse) like there is with single uses of strong serotonin releasers like MDMA, high aMT doses, or 5/6-APB.

 

[ephrem]

I experienced my first proper M-hole yesterday quite unexpectedly.

Had a couple of bumps earlier in the day and a couple of hours later did another, slightly larger, bumps sublingually.

Some time later I nearly blacked-out and slowly regained consciousness finding myself having a conversation with the song that was playing at the time.

Everything was blurred and I couldn't see the monitor, just a light source.

My vision got better eventually but I was severely cross-eyed until I crashed in bed.

Slept like a baby and woke fairly refreshed and sober.

I can't say I'd like to repeat the experience but it wasn't as confusing and deep my one and only K-hole was.

After the first dose I went out to buy some things in town and being out in public on MXE, that's a whole new level of awkwardness.

Still, good stuff!

 

[IamMe90]

Had my second hole last night on MXE. First time properly plugging the substance, and holy crap, all I can say is that this is a different beast plugged than snorted - it almost feels like a different drug. Lower doses are more euphoric and have more of a body high than lower snorted doses, and higher doses are more deeply psychedelic. The hole itself was frightening and I'm not sure how much I want to repeat it again, but it was deeply insightful.

 

[missimoo]

@psood0nym Yea Ur right mate. I was a bit cooked in the head after the "a&e" experience. I had been using in a stupid way for too long, then had a period of abstinence and then took ( don't know why, i know better, I'm experienced with drugs and know better) more then i would usually - i think partly because after my break I was so out if it I didn't know any better. and its taken me a few days to "come down" you were completely right, i was manic. a few day later im prepared to admit that. this stuff does cook your head big time.

a few days later and i see "i was still fucked up from the a&e trip"

Its hard to follow these threads that are now getting really tedious with newbie trip-heads (ffs I've being doing psychedelics since i was a teen decades ago, with all these (increasingly too often) "omg i see the light (insert 50000 words of bollocks here) posts" posts spouting absolute bollocks, its hard not get drawn into taking the piss a bit. out of boredom. and its ruining the bluelight forum really.

peace

x

(however i have managed to pick up a lot of french lol). and yes, I have stopped using for a bit because i was blatantly getting silly)
*i tried to send that a PM but it wouldnt let me ur inbox it tooooo full apparently)

 

[DwayneHoover]

Had my second hole last night on MXE. First time properly plugging the substance, and holy crap, all I can say is that this is a different beast plugged than snorted - it almost feels like a different drug. Lower doses are more euphoric and have more of a body high than lower snorted doses, and higher doses are more deeply psychedelic. The hole itself was frightening and I'm not sure how much I want to repeat it again, but it was deeply insightful.

It's very frustrating that no one ever offers any detailed subjective descriptions as what "holing" is like. I really respect your clarity and expressiveness, IamMe90...
> Could you make a stab at describing in detail the sequence of subjective sensations/perceptions that are involved in a MXE Hole?
> And also what exactly about it was "frightening" (I am guessing it was basically the standard confusion & panic that "Oh no, I did something terribly wrong and I am surely about to die"?)

 

[Mung Hunter]

Here's a bit of an interesting thought for anyone having these cold/dark, unenjoyable trips; maybe this is the chemical's own way of saying you're doing it too much? Personally I've been doing this compound on and off since it was on the market in December 2010. I have not had a single unpleasant experience to date. There were times when I may not exactly have enjoyed myself but it was basically a lack of emotion because I've had complete ego loss on some nights. But I also very slowly got to know it at first as it was a very new substance and I had no idea what it's potential was. Anyways my main point is that I never binge on it doing it for many days in a row. I've done it 2 nights in a row, but then I'll make sure not to do it for a while. This summer there were times were I didn't do it for 1-2 months because it seemed to kind of lose it's novelty, but when I tried it again after that it was like a whole new drug again. Like all drugs I believe that balance is key; the thing with this one is that since there's hardly a hangover, almost the opposite, people don't have as much incentive to take a break and I believe that that probably has a large part to do with people having bad trips after having so many good ones.

Also I find that this is the most pliable chemical I have ever tried; I have had so many different experiences on it just by entering the trip in a certain headspace. I can choose to take it when going out to show and dance all night having a great time; it's actually completely taken over mdma as my favourite edm event/dance drug. But at the same time if I want I can take it and lay on the couch all night while music guides me through CEV's that are so clear and controllable unlike anything else. I'm a very strong lucid dreamer so I'm used to being in my own dream world every night and am used to being able to create whatever I imagine out of nothing and I've been able to access that exact same realm on methoxetamine except that music can guide my visuals and I can still talk to the other people that I am tripping with and articulately explain everything that's going on in my CEV's, and can leave this place by simply opening my eyes.

I may sound like one of these, "this is the best drug in the world and will bring on a revolution" type of people but that's not it at all it. I realize that it's only a drug and I enjoy being sober just as much, if not more than being on it. But I must say compared to all the drugs I've ever tried(which is going on about 45-50 different substances now), this one really has some magic to it. Everyone just needs to be careful and balance their sobriety so that this wonderful magic doesn't disappear, and so that they don't lose their mind thinking that they're changing the entire universe by taking it; it's simply a drug that gets you high in the end. Be safe, have fun, and continue searching for knowledge.

 

[Mung Hunter]

Anyone have a better idea on the stability of methoxetamine if in proper conditions; in a sealed glass vial, away from light and heat. I would like to stock up in case it becomes illegal soon but wanna make sure I don't order too much

Also forwarding this again since no one's replied yet. I actually have a gram saved from my last batch from about 6-8 months ago so I will personally be analyzing the stability of it. I'm also saving 5 grams of my current batch to see how stability changes between batches. I plan on saving them for years so I will certainly let everyone know as soon as I notice any degradation.

 

[Splitz]

Um... I can no longer 'hole' on 100mg. I've had bigger doses before a couple of times, but what could I safely move up to?

I like to use amt, wait to come up, and then bang a large mxe dose up my nose. The synergy is amazing as many people have stated. I find that the combined experience creates an almost spiritually euphoric and definite psychedelic mindset. Managed to send 'energy' through linked hands to a group of people who were solely on amt and bring them up a level. I knew they wouldn't mind me not being able to get a sentence out. :D Anyway that's more for the combo thread probably.

Anyway, I'd love to experience the massive 'I feel like I'm dead. Why has the sofa just swallowed and regurgitated my friend?' feeling again, but I'm trying to be somewhat cautious with dosage.

 

[RUSHDAFUNK]

MXE Antidote

Just a little info on an experience I had the other week with MXE.

I had dropped about 50mg MXE about 15 minutes prior when my wife comes in and say will I be ready in a little while because her mom was coming over to do some stuff. I said oh crap I forgot and told her I just took the MXE. Had to figure out what to do to be presentable because she was already on her way and I needed to be there to work out some stuff with them. By 30 minutes since consumtion I was already getting a buzzing in my head , it was coming on hard. I had a bright Idea.

I took 2g of piracetam. Viola! no more than a half hour later I was nearly baseline. Well, that is to say fully functional. I still felt a weird light on my feet sensation and my head seemed like it was in an odd but very clear space. But in reality no one would have been able to tell and I was 100% functional.

I never thought the piracetam would work that quickly that well AFTER dosing the MXE.

 

[ColtDan]

Here's a bit of an interesting thought for anyone having these cold/dark, unenjoyable trips; maybe this is the chemical's own way of saying you're doing it too much? Personally I've been doing this compound on and off since it was on the market in December 2010.

fully agreed. once a week is sometimes too often for me, even in fairly small amounts. i was getting weird dark trips more and more often, so i was like "fuck this" for a few months... then was having a quiet night, and randomly did a few 20mg doses, and vola.... felt brand new, amazing, magical. fucking beautiful. it was like it rewarded me for having a break from it. having breaks from this stuff has been very beneficial, even though i was loving the uplifting afterglow on a weekly basis


as for people not sure if they're M-holing or not... you'll know if you M-hole. you disolve and "think" you're dead for awhile. i usually end up floating/disolving face first into my carpet. its like ego death or something. i can tell when a hole is coming when i feel like everything is vibrating, a huge amount of energy, and when i close my eyes its like static moving around and my whole visionary field has shifted... then i become connected to everything, at one. its been intense as fuck, on par with DMT at times

 

[Splitz]

you'll know if you M-hole. you disolve and "think" you're dead for awhile. i usually end up floating/disolving face first into my carpet.

This. This is what I miss.

 

[Mr.Hedges]

The more I explore, the more I learn. I feel as if a chemist took all of the knowledge and wisdom of Buddhism, turned it into a molecule, and quietly found a way to distribute it to the human beings who are trying to live that "one with the universe, quest for the knowledge of the cosmos" kinda lifestyle. Call 'em psychonauts, call 'em whatever you want, I like to believe that they are some of the last humans on earth who are still trying to figure out what this whole thing is about...While the rest of society distracts themselves with pointless gadgets and going shopping, unable to stop and sit in silence for a moment and think about what it REALLY means to even be a human being. We've been to space, went to the moon(myself included on a regular basis), to the depths of the ocean...us as humans, we've just gone everywhere and seen everything, and to top it off....the HISTORY OF OUR ENTIRE CIVILIZATION in every shape and form can be accessed at any time with the click of a button thanks to the internet. We have the most amazing capabilities as a human race right now to reflect on everything we have ever done since the beginning of time, to dig deep within ourselves and take advantage of where we are at this moment on this planet, to look through our history and decide which parts of our society we NEED to change, what outdated concepts NEED to go, we have the technology of the future...we just need the "right minded" people to guide the human race in the right direction, back to the basics, back to balance. Our society is so unbalanced and ridiculous, to the point where you can live the most mindless life possible if you want too...people today just distract themselves constantly, never taking the time to think about anything of value. It's what is missing from our world today. I think that this substance could help people take the time to slow down for a minute and do some reflection and meditation and possibly clear their minds for long enough so they actually have an original thought for the first time in their lives. Like when Albert Hoffman happened upon LSD, while the atomic bomb was being made, and he decided to go for a ride on his bicycle....He knew that the world needed to be healed and that violence wasn't the answer and never will be...I feel like we are living in a similar time. 2012 has been a crazy year so far and it's just getting started, I don't think the world is going to end or any shit like that, but I think that mxe may be the lsd of 2012. The world is in a pretty shit condition right now and humans are just getting worse and worse, from how they treat one another, to what they value most importantly, the list could go on forever. But I guess my whole point in this long rant is...I believe that a long time ago, when humans were still primitive and had to be violent all the time, when we still weren't able to just be at some form of peace with one another, our brains, unfortunately for us...disconnected this connection to our methoxetamine circuit in our brain, rendering life less and less and less enjoyable as our evolutionary chain degrades and we get further away from the original humans, wherever and whenever they existed.
All I'm saying is....I've never experienced a substance which I can take in capsule, sublingual, or a tiny little bump....and it somehow makes my entire day the best day I've ever had EVERYDAY. I know it's unrealistic for that kind of contentment to be a constant...it's downright not human...........But somehow this medicine has taken me from a depressed, in the gutter, ready for my time on this planet to be done, kind of a person....into someone who realizes now just how beautiful my life is. It's like my eyes have been opened for the first time and I can have FUN again, fun like a LITTLE KID again, and that's some shit I haven't been able to say for a long time due to opiates SUCKING the fun out of life and telling me how they are the only path to happiness.
All I know is, ropiates have caused me YEARS of pain and suffering, on top of the pain I brought to family and friends to the extent that I will always be embarrassed of the evils I done did once upon a time. Thanks to this substance, I have remained clean for 45+ days for the first time in over 2 years, and I have no intention of going back. The thought of the dirty little brown bag..................so disgusting, so life destroying............compared to the childlike fun of spending times with the people who REALLY matter to you on MXE. I REALLY hope that more opiate and drug addicts in general hear about this medication and start to realize that you can heal YOURSELF with a little knowledge, a little money, a little strength and faith in yourself, and the good old fashioned desire to exercise and go for a walk, which this substance makes wonderful. I've never done a "drug" that genuinely makes me want to try harder to be a better person in every way shape and form. Please, keepers of this sacred substance, BALANCE IS KEY!! Respect the methoxy, and it will bring you joy and enlightenment right when you need it most............Disrespect it and.........well................I think if you look through this thread enough you'll see where abuse can lead.
This is a substance unlike ANY OTHER EVER SYNTHESIZED! It is what the people of this world NEED nowadays...to COMFORTABLY meditate on the plight of the human condition. If we all meditated daily, respected the substance, spread the joy QUIETLY AND RESPONSIBLY...We could find ourselves in a beautiful new world. I believe this medicine has the power to help the sick, addicted, bored, and depressed more than ANY current medication on the market.
TREAT IT WITH LOVE AND RESPECT. IT WILL TREAT YOU RIGHT AS LONG AS YOU GIVE IT THE RESPECT IT DESERVES.

SORRY FOR THE RANT FOR REAL!!! Mr. Hedges out. ; }
I really do hope everyone stays safe and this one stays on the low as long as possible so as to not be dismissed as rubbish and forgotten forever. This substance could change lives, lets not get it turned into another SCHEDULE 1 BALL AND CHAIN. THE WORLD NEEDS METHOXETAMINES HELP!! People are evil!! and it shows the demons for what they really are. Play safe friends.

 

[OTGee]

I don't know why people are saying that this substance is amazing, sure the pure potency is very impressive but there is no way it can save mankind or help you become 'spirtually enlightened' etc, of course maybe it does this for you but seriously, the only self improvement I found from this substance was that it made you care less about other people and more for yourself. Now ive only ever used 1.5 grams of this shit in the whole time its been out and was pretty late to catch the MXE train so im not proposing im some kind of expert. To me this was exactly like other dissociates, a dark lonely experience that did nothing for self improvement and may be strong and make you feel very very fucked up but this shit has nothing on psychadelics. Maybe ive just had bad experiences but MXE made me be less selfless, less caring towards my girlfriend and gave me no inspiration to do better with my life apart from I felt like I should probably start being more healthy for my appearence. This not life changing though, it just made me want to look more attractive which is not what people should base there goals around. Maybe this shit works for you but im going to stear clear and keep my .5 for a year or something and see how I feel then.

 

[InterzoneAgent]

I've read about the DXM plateau sigma, and some of the things about that state really remind me of it. I wonder if that is something all dissociatives share - the ability to enter the sigma plateau (or some analogue of it) - by repeated doses. And if that is the case, then the state you described with MXE could be pharmacologically similar to that produced by a similar dosing regimen with DXM or ketamine. You may be correct that it is increased cumulative DRI activity. I too would be interested to know. The patterns of dosing to get there need to be just right. It's like you need to redose while your coming down from the last hole, but your redoses don't neccessarily have to be 'hole' doses. By the time you get to that state, you are so lucid, you are not really holing, but you are not sober either. It's like being both at the same time.

Yeah, although only highly speculative theories, very interesting anyways. As you said about dosages being just right, i remebered that the doses i took on that aforementioned occasion weren't huge by no means. Max 70 mg's per dose. And I had just few hours earlier came out of the most unexplainably deep mxe-experience by date, in which all my previous "unfinished" experiences with it were integrated into "a whole" and i understood the whole meaning of every instance and obstacle of my life and all this culminated with me reaching a neverbeforeseen peace with myself.

However being too greedy and dosing even after that resulted with that above mentioned, complete opposite state. It was like your mind telling you; "You have just reached perfect peace. There's no more to gain, you just go and dare you greedy bastard..."

I have never experienced the DXM plateau sigma tho i must add, never have even used the whole DXM all that much. Which is why acquiring the unbreakable cross-tolerance to it sucks even harder.

This. This is what I miss.

Yeah, that's the feeling i loved too, but lost very fast with the forming habit.

IMO there's only one good solution: Take a break, and long enough too!

Ps. It's good to take a break every once in a while also for your mental well being. To integrate the thoughts and ideas the mxe (or any other like substance for that matter) has brought to surface and separate the false enlightments from real self-improving realizations.

I don't know why people are saying that this substance is amazing, sure the pure potency is very impressive but there is no way it can save mankind or help you become 'spirtually enlightened' etc, of course maybe it does this for you but seriously, the only self improvement I found from this substance was that it made you care less about other people and more for yourself. Now ive only ever used 1.5 grams of this shit in the whole time its been out and was pretty late to catch the MXE train so im not proposing im some kind of expert. To me this was exactly like other dissociates, a dark lonely experience that did nothing for self improvement and may be strong and make you feel very very fucked up but this shit has nothing on psychadelics. Maybe ive just had bad experiences but MXE made me be less selfless, less caring towards my girlfriend and gave me no inspiration to do better with my life apart from I felt like I should probably start being more healthy for my appearence. This not life changing though, it just made me want to look more attractive which is not what people should base there goals around. Maybe this shit works for you but im going to stear clear and keep my .5 for a year or something and see how I feel then.

I think that dissociatives can have the tendency to make some of their users more egocentric and feeling distanced from rest of people. MXE and dissociatives in general differ quite a lot from psychedelics as you know but are also set and setting depentend. You should not go into it trying to chase a life changing experience, that's a sure way to never get one or maybe get even more than bargained for.

Maybe the dissociative experience just isn't for you? Then sticking to psychedelics is hardly any worse option, they are definitely not so addictive either and most of all offer usually more "grounded" insights into one's life in general.

 

[Survived Abortion]

I'll NSFW my response because it's only tangentially related to MXE:

NSFW:

There's no bad comedown whatsoever. I feel just like after a normal dissociative or opiate experience, which is to say a little foggy with a pleasant afterglow. The euphoria simply weakens until I reach baseline and stays there. When I first started using the DXM/ondansetron combo two summers ago, I used it maybe four times per week for maybe a month and a half (IIRC). I had posted about it on Bluelight when I first discovered it, but then deleted it and PM'd all the people who had quoted my post about it asking them to delete their quote of me because I was worried anyone who tried it would be hopelessly addicted (I've tried lots of highly addictive drugs, and nothing worried me like this). However, over the next few months I got a number of people to try the combo by supplying them the ingredients, and while they definitely experienced an interaction -- with all but one noting a significant drop in dissociation and increase in stimulated lucidity -- none had experienced the profound euphoria I did. Sorry if I got your hopes up... The only consequences from it were brain zaps, presumably from the DXM's SSRI effects (these zaps are what made me slow down with it). I originally stumbled across the combo because I was using 4 - 8 mg doses of ondansetron to avoid DXM nausea, and noticed all my DXM experiences were among the best I've ever had. When I took it without ondansetron it wasn't nearly as good. So I tried doubling my ondansetron dose and voila.

The DXM/ondansetron gave me the best raw quantity of intensity of euphoria I've experienced, and adding buprenorphine to the mix (and to a lesser extent, MXE), makes the euphoria just cartoonish and hard to believe, but there it is. It's like its working not through massive serotonin or dopamine release, but through targeting just the right sweet spot. I have no idea why selective 5-HT3 antagonism should do anything in conjunction with DXM. I thought it had to do with the SSRI effects, but I've tried ondansetron with proper serotonin releasers to test it without the effect, so I don't think it's just excess serotonin in combination with 5-HT3 antagonism that's responsible. The DXM combo will work day after day (though I've never gone more than four days in a row because I don't like the idea of dissociative over use). The most common side effect is that my teeth start to chatter during the surges of euphoria (not jaw clenching, but teeth chattering) which doesn't happen with DXM alone. I also get leg muscle spasms. I think it has something to do with serotonin, but there's no depleted serotonin effects in the days after (other than the brain zaps, but that's only after extended periods of overuse) like there is with single uses of strong serotonin releasers like MDMA, high aMT doses, or 5/6-APB.

Awesome response psood. Don't worry, it's not something I'll be rushing to try out soon, although I won't rule out the possibility in the future.

The reason I asked about how you felt after these experiences was because I'm quite fascinated by how various "qualities" of sexual dynamism and orgasmic peaks affect you afterwards. In french, the orgasm is called 'petit mort' (little death), and spectacular orgasms feel like a mini rebirth moment. Full-body orgasms leave you feeling cleansed and whole afterwards. I'm sure you've had different types of orgasms to know what I mean.

Perhaps that combo lets you easily slide in to a particular brainwave pattern, a very euphoric one, (and it may be that your mind learns it for future experiences and reinforces them)*, and so it may not be a case of catecholamine release or significant receptor downregulation in proportion to the intensity of the euphoria. The pharmacology of it wouldn't seem to lend itself to neurotransmitter depletion. If it goes along with what I mentioned above regarding transcendent orgasms, it may even be emotioanlly rejuvenating in some sense - although I'm willing to accept that that is fantastic jump in assumptions.

*Like with opiates, many users seem to have to learn to feel where the opiate euphoria lies, which could explain why others didn't get the same experience as you, although I would assume that the actual potential is there.

 

[kessin]

Oh man guys. It sucks hardcore. Was measuring out some MXE, made the bad decision to blow at something else at what I thought was a far enough distance, and totally just scattered 30mg MXE all over my desk, in an irretrievable layer of fine powder. v_v

 

[Transcendence]

Do people actually get euphoria from the m-hole, or find it fun?

I've had...interesting experiences m-holing (usually by accident): the whole death, dead, rebirth thing. I'd rate it as a positive experience overall, but very confusing and completely different from k-hole. Methoxetamine is one of the few drugs I enjoy much more on a lower dose. Ketamine is all about the k-hole, but M-hole is not something I would shoot for.

I've "traveled" to places during an M-hole, but as a lower organism with barely any perception of "self". Very little concept of human identity. No ability to comprehend or rationalize what is happening while it is happening. Similar to salvia in that regard.
Ketamine takes me across the universe, but much less messy and more euphoric. When I've K-holed, I still retain some sense that I'm human and that I've taken a drug and that's why this is happening. Methoxetamine is: wilt, die, gun-metal death void.

Oh man guys. It sucks hardcore. Was measuring out some MXE, made the bad decision to blow at something else at what I thought was a far enough distance, and totally just scattered 30mg MXE all over my desk, in an irretrievable layer of fine powder.

That's like what, 79 cents worth of MXE =P

 

[Transcendence]

Oh, and for people who aren't really getting euphoria from MXE, I recommend "layering" it. ~20mg, wait an hour, another 20mg, wait about an hour, another 20mg.