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The Big & Dandy Methoxetamine Thread - 5th Dose (you took too much, seriously)

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Heh.....I just got another gram today as well. I am taking this one sloooowww, trying to get the most out of non-outrageous (30-40mg) dosages and just enjoy it at this level and not go bonkers with the stuff8)

missimoo --- you really have no serious issues with 500-1,000mg per day usage?
 
congrats CI. know ur breathin easier now. and thanks to missimoo, psood, and everyone who's sharing their experiences with this.

Totally on-point about not posting tolerance-inflated dosing regimens without a cautionary note. And tolerance does seem to be a theme with this one. maybe it's the re-dosing. i rarely if ever took serotonergics more than once a week, if that, and virtually never re-dosed during those sessions. apples and oranges, yes, but point is that MXE is not one you have to talk yourself into consuming. far from it.

And i have to concur with the negligible WD/craving symptoms. i don't think i've hit it as hard as some others, but hard enough to notice (and be glad for) that particular aspect. and the long-lasting anti-depressant action is def a nice bonus. anyone else getting anything like 'hyper-intelligence' to go along with the insanity? lol.

Seriously I have a concern about the MXE supply, however. Seems like i'm not the only one to notice that the new, off-white batch is much, much more potent than a fluffy white batch previously obtained. Like maybe 5-10X more potent by weight. could be tolerance maybe, had like 2 weeks off. but it seems subjectively a bit different, too. same ballpark no doubt but maybe less euphoric/fuzzy. maybe old batch was cut, seems conceivable, but i think i liked it better! There are quite a few related analogs that could conceivably be substituted, but i'm grasping at straws without a GC/MS. Also I do not want to accuse suppliers of anything. I still have residues from both batches and if i pulled a few strings i might be able to get a GC/MS run done on them. am i being slightly paranoid or does anyone else get a bit of a funny feeling about the wide wide variety of reported effective doses?
 
suckerbunnie said:
missimoo --- you really have no serious issues with 500-1,000mg per day usage?
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No, he's just incapable of realizing the issues as of now. Which (please don't get me wrong) isn't meant as a personal insult ofc. It still does seem arrogant I guess, but everyone with a little drug experience at hand will know what I'm talking about. Some consequences, especially when it comes to the effect on things like personality developement and true addictive potential can only be evaluated after quite some time or some damages can never directly be related to the compounds because of the temporal distance between their manifestation and the drug abuse (abuse is the right word here I'd say). Physical damages often are compensated and therefore not apparent at all for a while, especially if the subjects are still relatively young.

First and foremost I'm almost certain that changes in personality are very hard to avoid with chronic use of dissociatives. I don't want to get too fair into detail, because that'd mean either becoming very autobiographical to a point I'm uncomfortable with or vastly generalizing my own experiences. From both my own experiences and what I could observe in heavy users though and also from what is to be guessed when looking at the role of nmda receptors in the brain, there will be personality changes that might be evaluated as negative by a lot of people in contact with the user.
 
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havent had any MXE for months.... very tempted to buy some again. even though i said to myself i wouldnt bother with it again due to the weirdness of that shit
 
missimoo said:
hardly any noticable craving. i probably crave tea more often in a day. cannabis far more. will be dosing tomorrow when home from holiday, am curious to see if tolerance has changed in 8...will be 9th day.
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Fortunately you haven't done the stuff as early in life as you've done tea and cannabis and not at the same frequency either because in that case things might look different. :P
Tolerance usually lasts exceptionally long with these substances, eventhough I can only account for DXM, Ketamine and PCP. It could very well be caused just by one of the substances in my case, but there's definitely a long term tolerance and I've heard that from every user of either one. Some even speak of a sort of irreversible behavioural tolerance that won't allow you to get dissociated anymore... (Oh nos!) It's reversible to a certain degree it seems, but you won't be able to keep up the real magic in the long run with frequent use. That's really a big downside to ketamine as well, especially with the poor options of administration and the massive doses even without tolerance. What some do with MXE now, a lot have been doing with ketamine in the past years. Doses of 5g per day have been reported more than once and they usually lead to major problems, eventually physical problems as well. It's amazing to see a tiny girl snort 1g pure Ketamine and keep talking coherently btw. That would be so fucking nasty when it comes to the drip (which would be rather soon I'd imagine).
 
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I haven't taken MXE for couple of months, I haven't ever been taking MXE much frequently.

And I'm still craving for it.
 
crOOk said:
No, he's just incapable of realizing the issues as of now. Which (please don't get me wrong) isn't meant as a personal insult ofc. It still does seem arrogant I guess, but everyone with a little drug experience at hand will know what I'm talking about. Some consequences, especially when it comes to the effect on things like personality developement and true addictive potential can only be evaluated after quite some time or some damages can never directly be related to the compounds because of the temporal distance between their manifestation and the drug abuse (abuse is the right word here I'd say). Physical damages often are compensated and therefore not apparent at all for a while, especially if the subjects are still relatively young.

First and foremost I'm almost certain that changes in personality are very hard to avoid with chronic use of dissociatives. I don't want to get too fair into detail, because that'd mean either becoming very autobiographical to a point I'm uncomfortable with or vastly generalizing my own experiences. From both my own experiences and what I could observe in heavy users though and also from what is to be guessed when looking at the role of nmda receptors in the brain, there will be personality changes that might be evaluated as negative by a lot of people in contact with the user.
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Exactly- dissociatives are extremely personality altering, but they do so in a way that is very subtle and causes one to not be able to properly judge their own behaviour. In all likelihood in a couple of years you'll be singing a very different tune- drugs that do not have obvious withdrawal symptoms (opiate withdrawals are hard to miss) will often 'trick' the user into thinking that their usage isn't a problem because they can stop whenever. The thing they don't seem to realise is that feeling the need to be under the influence 24/7 (which you would have to be taking 0.5-1g a day, no matter your tolerance), whether you're on methoxetamine or methadone, is a problem in and of itself. Don't bullshit me that 'you're a better person on it' or it 'helps my anxiety/depression'- the point that you start having to make excuses to justify your behaviour is the point that you need to step back and actually look at what the fuck it is you're doing. When you're buying a little under TWO OUNCES of PURE methoxetamine for personal use, you probably have a problem. Yes, it's much cheaper, but methoxetamine (on the whole) is dirt cheap- the discount you get on a 50g order would be irrelevant unless you had a high rate of consumption.

Daily use of dissociatives is not to be advised. Most dissociatives, methoxetamine included, have a multiple-day trail off ('afterglow') so compulsive, daily redosing will rapidly cause a steady concentration of the drug in your system. This leads to personality changes and impaired judgement which often results in continuing to redose.
 
Chronic NMDAR antagonism, especially at dissociation levels destroys your ability to create new memories and limit your ability to learn as a whole. Even with recreational doses, memory impairment is seen post use. Psychologically you run the chance of potential dissociated or delusional though process post use (but of course during use you would be clearly dissociated). So chronic use isn't very wise and can have detrimental effects within your real life obligations, ie. school. I'd say you'd have be reaching to say chronic use hasn't shown any negative effects. Your memory at least must be shot from daily consumption, and potentially modification of your habits with drugs. I'd imagine compulsive behavior with one type of drug can lead to compulsive behavior with another, though I haven't done the research to support this.


Legitimate benefits from NMDAR antagonism come from sub threshold doses which don't have dissociating effects, which prevent LTP (long term potentiation) from taking place for your NMDARs. Low doses have been seen to prevent LTP decay (increasing LTP duration) with some NMDAR antagonists, but studies show recreational or anesthetic doses to stop LTPs and have cognitive impairment. The anti-depressant effects of ketamine has been seen with low to sub-threshold doses, so high doses aren't necessarily needed for lasting anti-depressant effects.
 
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Cloudy, can you link me to a publication proving those long term effect regarding formation of new memories. I've been using a lot of dissociatives throughout the years and if anything my ability to memorize new information has simultaneously improved. The latter is probably related to my studying and actually training to memorize information, but still these substances didn't have any noticable effect like the one you describe. I'm not trying to doubt you, it does make sense considering their mechanism of action, but I'd still like to see some proof of that. Needless to say, I'll look into it myself as well.

For all others who hype the stuff and have a hard time taking it serious, here's a few links to erowid:
http://www.erowid.org/experiences/subs/exp_Ketamine_Addiction_Habituation.shtml
http://www.erowid.org/experiences/exp.php?ID=74560
http://www.erowid.org/experiences/exp.php?ID=10663

Enjoy! :)

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Uhm do many people experience this green/blue hue that was mentioned by some folks in this thread? I kinda wonder what causes that. Sildenafil can cause the vision to gain a blueish tint when overdosed as well, but I wouldn't know any other substance causing a response like that.

Btw I found a publication from June about what you mentioned Cloudy. Thanks again for the input. Here it is, it's freely accessible to everyone:
http://www.ncbi.nlm.nih.gov/pmc/arti...ne.0021328.pdf
 
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I first tried mxe about 2 weeks ago and I love it. I have learned that less is more and truly enjoy the effects it gives me.

I was overusing methylone and was up to about 10 grams a week toward the end of my use of it. I went through about 50grams in 3 months.

My serotonin levels were completely fucked up and I was so depressed. I was constantly thinking of suicide and how much my life sucks. After I began using mxe, I am more outgoing and feel much better about life. I am no longer depressed, my anxiety is (finally!!!) under control, and I can go out in public without worrying what other people think of me. MXE has truly saved my life.

I have been using it daily at about 85-100mg's.

It has changed my perspective on life and pulled me far away from the edge. I am so grateful for it. This is a drug that I will control as I do not want to lose the effects it has given me. I just need this in my life right now to help me get myself back on track, and hopefully afterwards I can slowly let mxe go and continue on and use what it has shown me to better myself.
 
erics2909 said:
fter I began using mxe, I am more outgoing and feel much better about life. I am no longer depressed, my anxiety is (finally!!!) under control, and I can go out in public without worrying what other people think of me. MXE has truly saved my life.

I have been using it daily at about 85-100mg's.

It has changed my perspective on life and pulled me far away from the edge. I am so grateful for it. This is a drug that I will control as I do not want to lose the effects it has given me. I just need this in my life right now to help me get myself back on track, and hopefully afterwards I can slowly let mxe go and continue on and use what it has shown me to better myself.
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I just hope that you are aware of the fact that this pattern of use can usually not be kept up with the same benefits, eventhough I do hear you when it comes to the outstanding potential as short term antidepressant drugs this class of drugs possesses.
Sometimes I wonder ketamine is not being utilized in clinical settings to break therapy resistent depressive episodes.

Cloudy said:
Legitimate benefits from NMDAR antagonism come from sub threshold doses which don't have dissociating effects, which prevent LTP (long term potentiation) from taking place for your NMDARs. Low doses have been seen to prevent LTP decay (increasing LTP duration) with some NMDAR antagonists, but studies show recreational or anesthetic doses to stop LTPs and have cognitive impairment. The anti-depressant effects of ketamine has been seen with low to sub-threshold doses, so high doses aren't necessarily needed for lasting anti-depressant effects.
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While I agree wholeheartedly with your words of caution, I personally have never experienced an anti-depressant effect from either Ketamine, PCP or DXM at non-dissociating dosages, eventhough I'm well aware of studies claiming otherwise. Maybe I'm just looking for excuses to get blasted though. :D

Btw there is a new study which found that ketamine reduced autophosphorylation and in consequence increased expression of brain-derived neurotrophic factor. They look at this as the key mechanism by which ketamine acts antidepressive, but I doubt the last word has been spoken. Needless to say, they're looking to directly inhibit CaMKII now without the need for messing with any type of glutamatergic receptor.

@limonov
Fantastic post. It's sad to see that all warnings are firmly being ignored though, but it comes as no surprise. I felt the exact same way about pcp and could never regulate my use of it. When it was available I used it daily.

People need to see that noone is trying to talk them out of using this drug or any dissociative for that matter altogether. One just has to realize that there are responsible patterns of usage and that even with knowing those patterns it is near impossible for most people who have a tendency to over-use and abuse to stick to them which will eventually cause massive psychological problems, not to speak of other unknown organic damages (ketamine's effects on the urinary tract and the gall bladder would be notorious examples in this field for unexpected drug effects). For these reasons it is not advised to promote or even glorify the excessive use od MXE, neither locally among your friends, nor online to other forum mebers and most certainly not here on bluelight which focusses on reducing the harms caused by drug use.
 
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thx for the good reads on this page.

FWIW, (and this is purely anecdotal), my memory was very noticably impaired during a period of daily dissociative use and for a few weeks afterwards. without any doubt, i had trouble with more intensive structured/organized thinking.

and yeah, it was only after stopping my use (roughly 2g MXE + 10g ketamine per month) that i realized the extent of this cognitive impairment... real odd, how that works.

however, back when i was using so regularily, i DID feel mentally sharper, with more frequent insights and long-term planning, and even a more positive outlook in general (the much-praised 'anti-depressant' properties?).
it's hard to put my finger on how or why these positive properties were "slightly off", but apparently that is the oh-so-subtle dissociation delusion (the ket konundrum!).
 
It's really weird how it seems to induce a delusional state in retrospect. In episodes of use though the reality presented to me there seems like it was the valid one, I've said to myself and others multiple times after using again after a long break, that it seems like the actual reality has been uncovered, as if a lasting understanding of the universe had been reached and everything before the dissociative use was basically a delusional, blinded state. I've praised the state many times when I was in episodes of use long before I even considered myself remotely bipolar. The stuff induces such a natural feeling flow with me, that I usually don't even consider questioning it's a state that I am supposed to be in, but have previously just failed to reach.

Unfortunately this flow usually bounces back with a vengeance on many levels and hearing stories of such immense tolerance only months after this pcp analogue has been introduced into the market is shocking and very worrying imho.

I don't see dissociative use being targeted as a problem by society at all though eventhough it is developing into a very common where I live. DXM is legal, Ketamine is not really regulated very harsh at all (customs once handed 30g ketamine out to a private person, knowing what substance they found in the letter, it's just classified as medication). I hear there have been times when pcp was a major drug of abuse in some areas. Can't say that's ever happened here, but ketamine is developing into a major phenomenom. Let's see how far this stuff will reach. I could imagine it becoming a media thing eventually, not sure it's a good thing that another dissociative is that easily available now.

If anybody is interested in wild dissociative stories btw, Dextroverse used to be a great resource. They have a pretty big cemetery as well if I remember right. ;)
 
still quite puzzled as to why this stuff hasn't reached the media yet. perfect massive media story to cause a shit storm. "new legal high drug similar to ketamine but much stronger and more dangerous being abused all over the country, people hallucinating and dying" blah blah. when the media do start talking about this stuff it will take off like a rocket, the same way mephedrone did

spoken to a few people around here that have tried it... but had no idea its called MXE. they called it "special k", think some people around here are selling it under that name, and it seems people aren't entirely that kean on it. compared to K anyway. ive not properly tried K, need to give that stuff a go
 
I should have noted that the cognitive impairments are short term effects, not lasting. I've noticed improved cognition post use of say 5gs of k in a week to two week period, but it wasn't noticed till after two weeks of the last dose. I can gather up all the sources showing recreational/anesthetic doses having impairment later to support my previous posts, though a lot of good info can be found in ADD threads

Occasional recreational use shouldn't have much impairment, definitely not last more than a few days ime, but I can't comment on MXE particularly. I have noticed longer lasting impairment from DXM than ketamine. Not sure if it has anything to do with the duration of the drug.

One big difference I imagine with MXE and other dissociatives compared to empathogens or stimulants is their dissociating and confusing effects profile. It really isn't that appealing to a lot of individuals. They loose to much cognitive abilities during the experience, and become so detached from there surroundings that it becomes confusing or even frightening. Especially if you aren't expecting such an experience. Negative experience on one dissociative naturally scares off individuals from trying other dissociatives I've also found.
 
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