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The Big & Dandy Methoxetamine Thread - 5th Dose (you took too much, seriously)

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@crook - there is a methoxetamine subthread about combinations with other substances... I have said that I find methoxetamine and ketamine to go perfectly with mdma... in fact I personally think mxe and mdma are on of the finest combos I've ever had... I now combine mxe every time I take mdma... I've never tried methylone... I have an excellent molly source so I've never had much interest in methylone...
 
I haven't had any Mx since Friday night and I'm missing it right now. That sounds really bad, it's only been four days. Roll on Friday :)
 
been 2 weeks since last mxe use. did like 3 g's in 2.5 weeks, having a great time. not much in the way of withdrawal, a lil' irritable for a couple days maybe. anyone else losing a lot of sleep over this stuff? it's not like coke where it is difficult to maintain control over use; mxe use for me feels very calculated, like i can plan a regimen for the night and actually stick to it. kind of insidious that way. anyone else ever been sucked in by a drug that appeared to not be addictive or have side effects? lol.

also glad to see some peeps discussing this opioid agonist/DARI business. here's my 2cent: mxe subjective effects must be differentiated from receptor interactions. yes, mxe feels opioid-like in some ways. i'm sure it has strong pain-killing properties; very closely related drugs are used clinically as anesthetics. but this is not necessarily due to interaction at mu-opioid receptors. pain perception is a complex phenomenon, and doesn't rely entirely on any one neurotransmitter or receptor system. nmda antagonists are well documented to modulate pain by themselves as well as modulate the analgesic effect of opioids. it is not surprising that it "feels" opioid-like, but this is different from actually being an agonist at an opioid receptor.

same thing with mxe and dopamine. the drug most certainly releases lots and lots of dopamine, but then again, so does almost every self-reinforcing drug, right? I guess there are no clinical studies on mxe, but it is closely related to ket and pcp, which probably do have info available, but again i'd be surprised to see direct DA receptor interaction. am i wrong?
 
Last night I was delighted and surprised to find myself experiencing MXE like I did a select few times with it when I first began its use. I have been using it three or four times a week for the past couple of weeks, as I’m a bit bored with the new location I’ve moved with my girlfriend to. The past few MXE experiences had been pretty standard fare, and I didn’t deviate much from my dosing pattern this time, so I have to attribute the experience to unknown psychological factors.

I plugged 30 mg, followed by 25 mg and then 25 mg more, with each dose separated by about an hour. JWH-018 was vaporized twice after each of the later doses. After the second dose I started to experience some signs of the unique mind state MXE had occasionally brought me to in the past, and which I thought I may have lost access to. It feels like a virtual world for infants prior to birth, full of a bright innocence and wonderment, with all its realms permeated by a static field of soft textures, and replete with comfort and joy. These feelings forced a series of neologisms out of my mouth to describe what I was feeling, which were strung together by absurd poetics whose phonetics not only served as bridges between the new words but seemed to shade the surfaces of this new world. I should have written them down, and will be sure to do so, should I experience the phenomena again.

The mind state evoked a song whose name I could not recall, but which I was surprised to find immediately by its track number on a CD where I had a vague notion I’d find it. During the song I felt my chest brim over with bliss, a deep assurance that where I am and the sequence of affairs I’m experiencing in my life now are what they should be by natural course.

This morning I awoke with a smile, and the reasons for it have stayed with me throughout the day.
 
^Sounds beautiful psood. You always seem to have some of the most magical experiences with whatever psychedelic drugs you take.

I'm interested, does the staggered dosing bring about that kind of 'sigma' feel you get after repeated dosing with ketamine? I have 25mg sitting there in a cap and I'm wondering whether I should swallow it orally or go rectal. Since I have never used MXE before - and my last use of dissociatives was 3 years ago with ketamine - I'd like to get the dosing scheme right. Also, when you are dosing like you did, are you measuring all your doses out beforehand or are you weighing doses whilst high? Thanks!
 
^In my experience staggering the doses tends to heighten the proportion of euphoric effects relative to other effects. However, I have not experienced anything so qualitatively distinct as a "sigma" type of high dosing this way. Rectal administration is almost as effective as intramuscular, so that's the route you want to go to conserve material. I typically measure out the additional doses while still dissociated, yes, but pre-measuring is always a good idea. Given the varied reactions to MXE, it's hard to say whether following my lead in regard to dosing will result in something even vaguely consistent with the effects I've reported or not (as stated, I don't think the experience detailed in my last post issued from the dosing regimen alone, but rather it was the work of unknown psychological factors). Good luck.
 
re Tolerance and withdrawals

dose as said 500mgs up to 1g a day (more often the later) for about 4 months. dose quickly went up to that to keep same effects...but never reached that level..

effects at that dose vary. usually will hole or get close 1g....over a several hour period. a dose of 100- 150 mg staggered over an evening. more then 200 mg at a time will produce a hole but usually leaves me unconciouse at 250+ and more or less in a mess. cant talk, time lose and often wake up halfway trying to ask someone what the hell happend...whilst not being able to talk which is getting really annoying to my other half!

over the 3 days i have been away and only took 1g with me. it lasted the 3 days. and to my suprise a couple of days when i have taken LESS has led to MUCH NICER effects. one line in a bar was more intense in many ways. very social. had a dance.

this is day 2 without any as i had to re-order over bank holiday. it didnt arrive today, and im going on holiday for a week early tomorrow. so that will leave 8 days with NO use.

so far on day 2 i feel NO EFFECTS from not having it. craving is VERY LOW..obviously i am slightly upset it didnt arrive in time, but this would be normal for ANYTHING so i wouldnt count it.

will update if this changes. and will ad if tolerance has gone down when im home.
 
Oops maybe I spoke too soon about mxe not being a proper D2 receptor agonist. Just found an article via the phencyclidine wiki that shows D2 activation with PCP, and to a lesser extent, ketamine:

^ a b Seeman P, Guan HC, Hirbec H (August 2009). "Dopamine D2High receptors stimulated by phencyclidines, lysergic acid diethylamide, salvinorin A, and modafinil". Synapse 63 ( 8 ): 698–704. doi:10.1002/syn.20647. PMID 19391150.
Click to expand...

This is not direct evidence, but certainly lends weight to the argument. Maybe one for ADD tho huh, mods?
Bless all forms of intelligence (dissociated or not)
 
I don't think another drug has effected me as much as MXE, and tonight was my first time. It changed me in ways LSD did to compare.
 
I had my first MXE experience this evening, and altough i can see it's use [for me] in combination with tryptamines I am concerned about the shallow breathing and heartrate during the peak.

Altough I didn't experience heart flutters [if that's the right word], it did feel like there were moments of arrythmia. It's not unusual for me to have heart flutters now and again [rarely though], but during this session the idea of heart flutters persisted.

I also had to take deep breaths often, but i guess that's to be expected with disassociatives?

There was no euphoria, no bliss, just detachment. That in itself is a nice break from the norm, and because of that I can imagine that a combo with tryps could be heaven.

It's an odd feeling though, and it does not allow me to be social at all. But thenagain, i'm not a social person to begin with.

I'll come back to MXE, but it's something i've to keep my wits about.
 
Alright, I've tried MXE many times now, but all the times i actually didn't like it, I can't see where you guys see the magic? The effects I get is:

Confusion
Dystopia/Sad feelings
Feeling of going insane
Stupidity

But low doses however, is very enjoyable. 10-15mg combined with a few beers is just perfect.
 
Bone14 said:
Alright, I've tried MXE many times now, but all the times i actually didn't like it, I can't see where you guys see the magic? The effects I get is:

Confusion
Dystopia/Sad feelings
Feeling of going insane
Stupidity
Click to expand...

What effects do you get with K then? Are you sure about the quality of your MXE?
 
Never tried K, I am sure that my quality is high, i tried from 2 vendors, and this last one is really powerful.
 
It could be your mind that doesnt like dissociatives, NMDA receptor antagonists. If I was you would drop it.
 
Random question but I figured this was the place for it.

Could this drug be used as a sleep aid?

I'm aware that using it longterm or regularly is more than likely not a good idea but I just wondered.
 
It's actually quite stimulating. Getting to sleep on MXE takes longer than getting to sleep sober, so no.
 
Ah, thanks for the responses! I just recall the last time I did K, I got higher and higher until I fell asleep. I was pretty tired though. Its a long story but basically I wondered if the same applied to mxe. Oh well.
 
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