The Big & Dandy Methoxetamine Thread - 4th Dose (don't overdose)

[Taoluo]

How were you able to consistently take the same dosage every day?

The few times I have used it consecutively days in a row I always had to up the dosage to get the same effects...

Obviously my tolerance rose but not by *that* much. Also do you plug? I find any other ROA other than plugging takes like double the dosage I'd need to get to the same place I'd get by plugging.

 

[KingBlueTwista]

Interesting. I wonder if the idea that 'YMMV' applies to speed of developing tolerance as well..

Yeah I plug, it's by far the best way I've experienced, bar putting holes in your flesh, which doesn't really seem worth it. Still, my tolerance has gone up to the point where I usually plug around 150mg in one session to be at the same place I was with no tolerance and plugging 50mg - this is after about 2 weeks of ingesting daily.

Don't think I'll be buying anymore once my stash runs out, the temptation is too much and my self-control too little :/

 

[NeuroPsyence]

I know exactly what you mean. I've been taking this on and off for a few months now. Most of the time I use this now I feel it to be very cold. It's such a strange substance and it's getting to unpredictable now. Ive suffered 2 panic attacks on it and it scared the shit out of me. I still however get some amazing trips from it. On Saturday night I introduced a friend to it and we had an amazing time.

I can relate 100% to everything you've said, which makes me feel less alone.

And yes, when i first discovered MXE and was abusing it daily, I never even got a twinge of craving for another drug, even when I went out on low doses of MXE I'd avoid alcohol. And it wasn't just the drugs I no longer craved, it was bad habits of mine, instead I craved good habits and to get everything in my life into order. during the first month of using MXE I was certain that I found some sort of miracle cure for many of my problems. Eventually those habits returned and MXE was making me lazier than ever...

When I started taking it daily I thought it was amazing. It cured my depression, gave me energy and motivation to do stuff and just generally took me away from my problems. All of this has gone now. It just makes me have bad thoughts now. I know I was abusing the stuff but kept taking it anyway hoping that magical trip would come again. Strange thing is that it did, but it's not worth the cold, isolated feeling I got for so long.

Not that I'm proud of it or anything, just putting the information out there but I've been taking 40-60mg (plugged) of MXE daily for a little over half a month now with no negative repercussions that I can find other than the occasional time when I took it while I was feeling not so great (tired or sluggish or whatever) and it just exacerbated those feelings while I was on it.

Not the smartest thing to do but meh. I'm off it now for at least another month.

Thank you all for sharing your experiences. Reports from regular users of this drug are valuable to our understanding of the drug's long-term effects, which are often difficult to predict from prospective models of the drug's pharmacological and toxicological profiles. Please continue to provide details about your experiences, updates on how you feel the drug has affected your physical health and mental well-being, etc.

Obviously my tolerance rose but not by *that* much. Also do you plug? I find any other ROA other than plugging takes like double the dosage I'd need to get to the same place I'd get by plugging.

This is consistent with my experience as well as with the pharmacological models we have for methoxetamine, which would not predict a rapid increase in tolerance (except from extended periods of high-dose use). However, I would note that many users have reported higher-than-expected increases in tolerance from methoxetamine use, several of whom have suggested that increases in dosage by as much as 5mg per day are required to achieve consistent effects. This is indeed an aura of mystery surrounding this drug, and even those who are studying its effects on a molecular level continue to be surprised by the apparent disparity between what is suggested by its prospective mechanisms of action and the unusual effects that seem to result from its use and its interactions with other drugs.

Plugging is a very effective ROA for this drug, nearly equaling intramuscular injection in apparent bioavailability. Why exactly it seems so much more effective than intranasal and sublingual administration (which both also bipass first-pass metabolism) is not yet clear, but this is certainly my favorite route for higher dosages.

Have other users noticed an apparent increase in the mental clarity of their experiences when the drug is administered intrarectally? Conversely, have other users noticed that oral administration seems to produce a more mentally clouded experience than sublingual and intranasal administration? The rate at which MXE is absorbed seems to have a more significant effect on the mental aspects of the experience than with most dissociatives, in my opinion.

 

[superhed]

Whilst I agree that plugging is the way to go with this one I concur with KBT that tolerance still becomes a factor with this ROA (for me) ...strange you seemingly weren't effected. I've done a half gram or so in the last few weeks with as much as 10 days between or as little as 1 day but my tolerance has definitely built and whereas 1*30mg was sufficient before I now tend to do 2*40mg to get to where I want to be....tis a mysterious one indeed this mxe.

In fact - and just throwing this out there but I'm onto a new batch and the first couple of times I had it I was convinced after the first plug that it was cut or different gear because it just wasn't sending me into space like before. It *seemed* that even allowing for tolerance the first hit just wasn't kicking in like the earlier stuff did. To add to the to confusion it wasn't just the initial hit that seemed different, the duration of the buzz from it seems to have altered and whereas I would be gubbed for 3 hours I now feel 'straight' about an hour after the initial plug..

The new stuff does look different and appears less 'salty' than the first batch but the thing thats convinced me its in my mind is that when I do decide to do a 2nd hit this one invariably sends me into the stratosphere!! The cumulative effects are waaaay beyond expectation.

 

[NeuroPsyence]

Just to add my experience: i've combined MXE (in doses up to 50 mg nasal) with mdma, amt, 6-apb and 5-apb lots of times and never had any noticeable negative effects (only positive ones). (this is not to discount anyone else's negative experience of course; just to add my anecdotal data)

As much as I appreciate your contributions to the available anecdotal data regarding this drug, out of concern for your safety I would have to recommend that you at least avoid combining it with 5-APB and also consider avoiding combining it with 6-APB as well. These drugs have created a lot of problems for users when co-administered with methoxetamine, and it would not be wise to continue using them in combination in light of the multitude of netative reports that are now available.

I see that you mentioned this later in your post:

This substance can certainly cause uncomfortable experiences if dosed haphazardly; but i've found that as i've got used to what each dosage roughly does and how long it lasts, and make sure i prepare my set/setting beforehand, i only get positive experiences - ymmv

Please remember that you are over 99% genetically identical to everyone else on the planet. Just because you have not experienced a negative interaction when taking MXE on top of a monoamine releaser, particularly those which have been known to cause serotonin-syndrome-like-symptoms (i.e. 5- and 6-apb) in your experience so far does not mean that you are not going to have one.

To answer another question above: 3-meo-pce does have siginificant stimulation all the way through (and 3-meo-pcp has even more - based on not many trials): in general they both feel more stimulated(/manic?) than mxe to me - also, both leave you a bit more physically drained and have a longer afterglow (half-life?) than mxe (up to 2 days - this is really nice, but can be inconvenient if you need to do stuff)

Structure-activity relationships would suggest that the ketone does indeed decrease the potency of an arylcyclohexylamine's DRI/D2 agonist properties relative to its NMDA antagonist properties-- in other words, it makes them less stimulating and more dissociative at a given equipotent dose. Have you tried any of the 4-MeO substituted PCP or PCE derivatives?

 

[incognition]

This is consistent with my experience as well as with the pharmacological models we have for methoxetamine, which would not predict a rapid increase in tolerance (except from extended periods of high-dose use). However, I would note that many users have reported higher-than-expected increases in tolerance from methoxetamine use, several of whom have suggested that increases in dosage by as much as 5mg per day are required to achieve consistent effects. This is indeed an aura of mystery surrounding this drug, and even those who are studying its effects on a molecular level continue to be surprised by the apparent disparity between what is suggested by its prospective mechanisms of action and the unusual effects that seem to result from its use and its interactions with other drugs.

Can you possibly explain the mechanisms behind the longlasting dissociative tolerance that ketamine use can create?

 

[drugs]

So I finally tried this stuff over the weekend. 60mg oral dose. Very little previous experience with dissociatives - tried 4-meo-pcp once.

I was kind of dissapointed, it was a nice high, but I felt like it never reached the depths I was hoping for. I felt fairly coherent throughout most of the trip, It got pretty weird when I tried to go to sleep 4-5hours later though.

4-meo-pcp was much more intense for me, though I did that on the tailend of an lsd trip, so its not a completely valid comparison. So far I much prefer 4-meo-pcp.

 

[Taoluo]

Have other users noticed an apparent increase in the mental clarity of their experiences when the drug is administered intrarectally?

Definitely. The high feels much cleaner (funnily enough) when plugging.

 

[Frogster]

could it be that MXE has no nature of its own. It seems that it is just a modulator or catalysator for other compounds.

Like a sort of philosopher's stone that can turn a ball of shit into a golden crystal.

Alchemy revealed!!!

Or not???

 

[Vader]

could it be that MXE has no nature of its own. It seems that it is just a modulator or catalysator for other compounds.

Not. It's certainly active on its own.

 

[Frogster]

you have always something inside your guts, and may it be the rotten rest of your MaccyD Burger that can be twisted into psychadelic stuff

you have to be fasting at least 2 days before you can be sure that you are digesting no exogen substance...

 

[IamMe90]

Not. It's certainly active on its own.

I don't think he was saying that MXE is inactive, but rather that it's a dull substance on its own/that it lacks a very unique character but is great for potentiating other substances. that certainly seems to match reports, to a degree

 

[Frogster]

I don't think he was saying that MXE is inactive, but rather that it's a dull substance on its own/that it lacks a very unique character but is great for potentiating other substances. that certainly seems to match reports, to a degree

Thanx man.

That's what i meant whith "catalysing"=poteniating.

i furher mentioned "modulation", means that it alters the character of other substances...

 

[polidelaiko]

I find it great on its own and in different dosages and ROA´s, AND it was great as a lauchpad for DMT.
I wonder if it works the same wiith salvia... ketamine made salvia trips easier...

 

[Ayrios]

I can't help but feel that I am missing something with MXE..
At low doses (10-20mg up the nose) it felt ok, like dirty ketamine but not as fun as ketamine at all. Tried this maybe 3 or 4 times.
At higher doses (45-60mg up the nose) I felt like shit, dark images and general dysphoria to be honest. Mindfuck and depression. Not fun, recreational, spiritual or teaching in anyway to me. Whereas ketamine (although I don't use it very often any more) can be all these things dose dependant.

I got a gram in december 2010 and all my experiences were from this gram, has the quality/purity changed since then? Any advice for other ROA or anything else that maybe I am missing? If not I guess its not for me and I'll stick to the true Psychs and K

I agree and wrote about this on page one. I don't think many of its chief proponents have had K, or at least clean IM K. This one's overrated and unappealing if you have grounds to compare. As for ROA, I've never snorted it, but have IM'd it a couple times which should be the ideal route. Fun for 45 minutes, then just depression and dysphoria.

 

[Transform]

Just want to pose another time the question of the smokeability or the aptitude to vaporize/vapourise this compound.
Tried few mgs by myself some time ago, but 1) it were 5mg max. and 2) I wasn't really sober beforehand.

Am really interested in any information on this; dosage, time course of the experience (if there was any), general quality of the experience - also by comparison with the other ROAs -, chemical know-how inspired "vapeing MXE is generally im-/possible because ..." ... and so on and so forth

Simple vaporisation: heating MXE (10mg) with a layer of glass in between.

At first, a small amount of white vapour, then a lot of white vapour as compound starts to bubble. Brown goo, easily soluble in acetone is found to be left over.

Took some into mouth at first, faint bitter taste which isn't pleasant. As it touches the back of the throat it is distinctly unpleasant, a burning sensation. No desire to inhale at all. 10 minutes later there is a faint taste of blood in the back of the throat.

In short, no. MXE decomposes, has an incredibly harsh smoke and appears harmful.

 

[.tOobi.]

anyone combined it with changa?

10mg MXE sublingual + repeat puffs from the gvg filled with 1:1 changa (b.caapi,lotus,damiana,mint leaves + spice)
produced tons of

is this combo safe? consider the reversible maoi..

 

[Pb109]

A weird thing I have also noticed about this drug is that certain songs get stuck in my head and I just can't get rid of it. My usage pattern was 0.5 grams snorted throughout 3 days with a couple of days rest.

Through the day the song would be present but when I tried to sleep at night it would be amplified so much and drive me crazy.

Has anyone else experienced this from prolonged use?

(the song was north country boy by the way lol)

 

[Frogster]

A weird thing I have also noticed about this drug is that certain songs get stuck in my head and I just can't get rid of it. My usage pattern was 0.5 grams snorted throughout 3 days with a couple of days rest.

Through the day the song would be present but when I tried to sleep at night it would be amplified so much and drive me crazy.

Has anyone else experienced this from prolonged use?

(the song was north country boy by the way lol)

got that side effect too sometimes. It's related to excessive dopamine in the synaptic cleft due to MXE's DRI action.
Downers help. Some piracetam and/or pregabalin before sleeping will cure it.

Alternatively any benzo, opi or antipsy med. This would be a bit the hard way tho...

 

[knock]

I don't think he was saying that MXE is inactive, but rather that it's a dull substance on its own/that it lacks a very unique character but is great for potentiating other substances. that certainly seems to match reports, to a degree

I would say that it's not a dull substance at all, its character is multi-faceted and it combines fantastically with (as opposed to potentiates) a number of other substances.

I do agree that many reports read as if it's dull, but many other reports read otherwise. The effects are variable, or flexible. Read nanoshot's posts, after he finally managed to find the dose that suited him. He thought MXE was dull at first, compared to his fully immersive ketamine trips, but suddenly started raving about it and comparing it favourably to ketamine.

I combined with marijuana for the first time at the weekend and had the most powerful psychedelic experience I've ever experienced, it was truly astonishing.

I don't know what dose as I was randomly dabbing over several hours, but it was probably around 100-125 mg. I was well under the influence but capable of managing myself. I was with friends on a weekend away. I smoked a couple of puffs from a joint and it threw me completely. I became extremely sensitive and someone said something which was probably throwaway with no harm intended but it completely destroyed me. I made my excuses and headed to bed to hide. My close friend came with me to make sure I was OK and we hugged. As we hugged I experienced my friend as a glowing sphere of love and the love passed into me and soothed me. It was (or seemed to be) wholly real and beautiful.

I lay down in bed to come to terms with things. My consciousness was transformed, I experienced around and within me the dance of life, which was an infinity of interconnected 3D "space invader"-like beings morphing and reproducing within an infinite space. The dance was urging me that I had no choice but to reproduce and die. I was confronted with my death and I thought at first it was trivial but then the horror of it came to me, the sheer horror of having to die, and only by reproducing would that terrible fact be counterbalanced. Clearly this is a theme for me in my day-to-day thoughts but this was the idea made tangible in my very being. It was also clear that all our activity on this earth is directed towards this end. Our friendships and social roles are all delineated around this inevitable fact, no matter how we dress things up, how sophisticated and aloof we may think ourselves from the mundane fact of birth, reproduction and death, that is the framework for everything that happens, it is the process in which we are made, we exist and in which we are destroyed.

It took me a while to calm down, my heart was racing for quite some time, but finally I dissolved into bliss and then sleep.