The Big & Dandy Methoxetamine Thread - 4th Dose (don't overdose)

[Vader]

Promethazine. Methaqualone. Desmethyldiazepam.

Took the Airline Flight Nr.7 with molecular Methyl-Oxy-Amine-Flux-Capacitor propulsion to stay a good while in MXEco for Eastern.

Now heading back with Submarine Diveline Nr.2 with nuclear PirateCTam-QuietAPin-SirTransLine propulsion to JAHpan for Christmas.

At least you know it's nonsense.

 

[Delsyd]

^exactly. having meth in your name does not mean it acts on dopamine.

 

[IamMe90]

dimethyltryptamine ... damn thats a dopamine rush l0l

 

[PoppyLlama]

hahaha I was just thinking the exact same thing with dimethyltrpyamine lol
I seriously prefer the DMT dopamine rush to the Methamphetamine one...its just so much more Dopamine-y ya know?

 

[socalthizzn]

I never claimed it was fact
Just a thought.

 

[oSpherical]

Sometimes I wonder what it is about MXE that I actually enjoy. I always feel drawn to it, make a habit out of it, think of it as something wonderful, however, I find the trip to often be depressing or uncomfortable, and often tell myself that I need to stop MXE altogether whilst I'm tripping on it.

But it's not that simple, because when I've lost all faith in it and tell myself that I'll try it once more, it offers me a breathtaking journey into a new world, entirely renewing my faith in it, yet afterwards I ask myself what it was about the trip that I enjoyed so much and can't put a finger on it...

I don't experience much euphoria, it doesn't offer anything practical like stimulants do, I can barely get any tasks done on it, and I don't even remember the trips very well afterwards as it makes my memory suck... it doesn't even help pass time since time feels like it's going slower than ever on it...not to mention the often unpleasant sound distortion/tinnitus and blurred vision.

Yet there's something which keeps me coming back every time, like an abusive spouse whicjh treats me badly yet apologizes and tries to make everything better when I'm about to leave...

It's such a difficult drug to understand and comprehend, with every trip having a different flavour to it - it can offer all the comfort in the world or be cold and unwelcoming.

Am I alone in experiencing this?

 

[e1evene1even]

Took a bit yesterday, wasn't planning to but I had a hangover and was feeling a little dodgy and wanted to be productive.

I wasn't after the dissociative effects but the stimulant and anti-depressant effects and it worked like a charm.

I ended up watching 'Limitless' later in the night which I loved though the new 'miracle drug' which turned out to have negative side effects plot line had me thinking about MXE and how it could also end up having long term negative effects which makes me want to be more cautious using it.

Even though I took it at 4pm I wasn't able to sleep until after 5 and I had to get up at 830 for work. Seeing as I barely slept I feel surprisingly great this morning (better than most Mondays when I have had a lot more sleep).

I was thinking this might've been a Modafinil Monday for me, but I don't feel I really need it and I'm not confident on the safety of the combo (even though I took the MXE 19 hours ago).

I'm curious if anyone's tried this particular combo, or has an educated guess on potential interactions?

 

[amanitadine]

Pretty hilarious how these multi-mega threads around "new drugs" always follow the same chronology over the years. Starts out great and informative, and slowly declines into nonsense and horseshit.......

Sorry.. . admittedly, this post isn't that constructive and reeks of nonsense and horseshit itself.

There is a method to my madness.......

 

[Albion]

Pretty hilarious how these multi-mega threads around "new drugs" always follow the same chronology over the years. Starts out great and informative, and slowly declines into nonsense and horseshit.......

Sorry.. . admittedly, this post isn't that constructive and reeks of nonsense and horseshit itself.

There is a method to my madness.......

Your method just gave me one hell of a dopamine rush. But then it would. It contains meth.

 

[csrpj]

i got my first MXE batch and plan to start experimenting on weds. the first stage of my experimenting is to get a feel for the smaller dosage, increasing it till i get a feel for what a large dose is about, and later use whichever suits me. i'm thinking of going sublingual, starting 10mg, next time 20mg, then 30...

good starting dosage and intervals?

what about the frequency? since tolerance is a factor, would it not makes sense to do 10 one day, 20 the next, and 30 the next day?...what about every other day...?

 

[NeuroPsyence]

Hello Bluelight. This is my first post here on the boards; I was just browsing this thread this morning, and I thought I would add some input from my research and experience.

So should i not be mixing mxe + mdma? Cause it feels so good to take a bump after my peak.

Thats a good question, and one that has been perplexing anyone who has attempted to form a theoretical basis for the integration of MXE's proposed pharmocological profile and the ancedotal reports that have been flooding in from its many users. The combination of MDMA and MXE has been reported with positive results (including myself, but this was before the first reports of problems with combining bk-MDMA and MXE began to come in, and I had the advantage of having nuclear magnetic resonance spectroscopy at my disposal, which suggested that my sample of MDMA was 97.9% pure).

I am honestly pretty upset to see all of the reckless combinations being proposed here, especially given the rapidly accumulating body of information suggesting that this chemical poses the potential for dangerous interactions with other drugs, especially monoamine releasers. The only drugs that one can be reasonably certain will not pose any compounded negative effects when combined with methoxetamine are cannabanoids and serotonergic psychedelics. And in both categories I would recommend caution in combining two drugs that have not been formally pharmacologically profiled.

 

[NeuroPsyence]

Baaaaddd idea. MXE combinations seem to be commonly linked with serotonin syndrome, which is understandable given the problems people have had in combining it with MDAI, 5-APB, bk-MDMA, etc., but that would not be your greatest worry with your proposed combination.

MPA likely binds to SERT in a very similar manner to methamphetamine, and it probably competes directly with dopamine reuptake in the neuronal synaptic cleft too. And moreover, It's likely a damn good dopamine releasing agent if its structural similarity to methoxetamine is any indication. Combine it with a dopamine reuptake inhibitor like MXE and you are just asking for trouble.

This is very true, and the weight of evidence in the in-vitro research that has been conducted regarding the interactions between arylcyclohexylamine dissociatives and other drugs that affect dopamine release or reuptake, as well as the ever increasing number of reports from users who have reported symptoms similar to those associated with serotonin syndrome resulting from drug combinations that primarily pose interactions related to dopamine, would seem to indicate the possibility of a counterpart to serotonin syndrome in which a flood of dopamine creates an extracellular or synaptic state which is toxic to the neurons themselves. Although the severity of the neurotoxicity posed by a "dopamine syndrome" would seem to be less than that of the more well established serotonin syndrome, the harm is compounded by dopamine's considerably more significant stimulant and excitatory effects, especially related to dangerous increases in systolic bloodpressure and other cardiovascular problems.

I would warn anyone who is considering combining methoxetamine with any other drug that affects dopamine release, reuptake, or receptor agonism, to carefully research the theoretical interactions posed by the combination, as well as any reports that are available from users who have already attempted the combination, because as the problems associated with MDAI, 5-APB, and particularily bk-MDMA used in combination with MXE have shown us, we do not fully understand the underlying mechanisms berhind methoxetamine's psychoactive action, or the risks posed by combining it with many other drugs.

I wish it were all just as simple as Serotonin Syndrome or Serotonin Syndrome.

Yeah, if only it were one of these two things, our troubles would be solved.

 

[suckerbunnie]

what about the frequency? since tolerance is a factor, would it not makes sense to do 10 one day, 20 the next, and 30 the next day?

Not at all. Tolerance really isn't that great a factor with mxe, except after a rather prolonged period of useage. Much much less so than the tolerance that rapidly builds with ketamine useage even at moderate dosages. And your outline for approaching this material is a wise one. I myself went straight for 50mg IM'd right off the bat and it was wonderful. But then I am used to going through 6 or more grams of ketamine within a 2 day binge and so it wasn't overwhelming. Oh, and it is interesting that I have felt neither the need nor desire to indulge in the K for the past 3 months and certainly since i encountered the methoxetamine

 

[NeuroPsyence]

Do we actually have any proof that MXE doesn't act on serotonin at all, even indirectly? The fact that the methoxetamine related death was caused by mixing it with a drug that only acts on serotonin should be enough to point the finger squarely at MXE messing things up.

We can be fairly certain that MXE does not directly interact with serotonin as an agonist, or releasing agent from its structure. That it completely lacks any SSRI properties is less certain, although the weight of research on arylcyclohexylamines would not suggest that this is not the case. There are numerous mechanisms by which a drug can interact with Serotonin indirectly, including competitive interactions with serotonin reuptake, interaction with serotonin transporting proteins (SERT), and many others. It is possible that methoxetamine could be involved in one of these, although I would not be inclined to believe that it acts as a major contributor to its mechanism of action. However, minor mechanisms that are overshadowed by the drugs primary mechanisms can become more significant with the drug is co-administered with another psychoactive agent, and this would seem to be evident in the notable death in sweeden of the user who simultaneously injected high doses of MDAI and MXE intravenously, although this does not necessarily mean that the underlying negative interaction was related to serotonin.

All i know about this drug is from what i heard from people trust. But nowhere did it mention that it acts on seratonin. Not that i know anything about this but i would guess it acts similarly to other NMDA agonists.

This is a reasonable assumption in most cases, but it would seem that methoxetamine possesses a mechanism of action that does not exist with Ketamine, which does not seem to pose the same potential for negative interaction with monoamine releasers that MXE does. The real comparison would be with methoxetamine and 3-MeO-PCE, but because the latter has been used orders of magnitude less on a global scale than MXE, we simply do not have the ancedotal reports to indicate whether methoxetamine's non-ketone cousin would possess any mechanisms other than NMDA antagonism and dopamine reuptake inhibition.

 

[NeuroPsyence]

I remember Shambles saying he suspects that there probably is an equivalent dopamine version (dopamine syndrome?) that may follow the same basic principle. If this does exist, it seems a much more likely candidate to explain my experience. Could possibly explain why MXE and all those heavy releasers/SSRIs get on. Perhaps 5-APB is more dopamine orientated?

The existance of a "dopamine syndrome" is still far from proven, but I would not rule it out given the number of reports of serotonin syndrome-like symptoms that have resulted from combining multiple drugs that interact with dopamine. There has been little research published on testing the validity of a "dopamine syndrome" model one way or the other, but research that will enhance our understanding of such phenomena is currently being conducted. I will provide links to the studies being performed on this type of interaction as soon as they are published, likely in early 2012, and perhaps even earlier if I get a chance to peer review the data myself.

I assume that mxe effects dopamine because of a) The euphoria matces up perfectly with other stimulants (even mdma after the peak effects of it have worn off) B) it leaves me with a stimulated feeling throughout similar to mdma after the peak effects of it have worn off, cocaine, low dose meth/amp wich i believe is a side effect of dopamine release? C) methoxetamine.
This is just my theory im not claiming to be facts.

It is a virtual certainty that methoxetamine affects dopamine, specifically as an inhibitor of dopamine reuptake via the same mechanism as ketamine. D2 agonism is also possible, but from a structure-activity standpoint, it would seem less likely than ketamine to possess this trait.

A) I don't think you would find too many people who agree with you on this one. The effects produced by most stimulants are not generally considered to resemble the subjective effects produced by dissociatives.

B) Methoxetamine appears to exert most of its dissociative potential during the first 3 hours after its administration, and the remainder of its duration of action seems to be dominated by its properties as a dopamine reuptake inhibitor. Why exactly this is the case is not well understood.

C) I see people have already jabbed you pretty hard for this one but I'm inclined to think that anybody who suggested what you did here probably shouldn't be using unresearched drug.

 

[oSpherical]

B) Methoxetamine appears to exert most of its dissociative potential during the first 3 hours after its administration, and the remainder of its duration of action seems to be dominated by its properties as a dopamine reuptake inhibitor. Why exactly this is the case is not well understood

The MXE afterglow often feels very, very similar to a stimulant such as MDPV. I don't know much of neurotransmitters, but dopaminergic drugs all have a distinct flavour to them, which MXE's afterglow matches. The mania often associated with MXE seems to solidify this.

I can't see where the claims of serotonin are coming from myself, I can't detect even a hint of it, not to mention even mild serotonergic give me horrible brainzaps for days after use and leave me feeling depressed and my body heavily taxed.
The euphoria from MXE also isn't the hollow euphoria serotonergic drugs give.

It's really not my place to theorize what people are experiencing when they claim seratonin syndrome, since again - I'm entirely uneducated about this, but to me it seems likely that panic attacks could be the root of some of the claims.
I full well know how a panic attack can make you feel certain your body is shutting down on you, and weird sensations turn to what feels like pain in your mind.

I've had a panic attack on MXE once, and it wasn't pleasant at all...

 

[Albion]

This is very true, and the weight of evidence in the in-vitro research that has been conducted regarding the interactions between arylcyclohexylamine dissociatives and other drugs that affect dopamine release or reuptake, as well as the ever increasing number of reports from users who have reported symptoms similar to those associated with serotonin syndrome resulting from drug combinations that primarily pose interactions related to dopamine, would seem to indicate the possibility of a counterpart to serotonin syndrome in which a flood of dopamine creates an extracellular or synaptic state which is toxic to the neurons themselves. Although the severity of the neurotoxicity posed by a "dopamine syndrome" would seem to be less than that of the more well established serotonin syndrome, the harm is compounded by dopamine's considerably more significant stimulant and excitatory effects, especially related to dangerous increases in systolic bloodpressure and other cardiovascular problems.

I would warn anyone who is considering combining methoxetamine with any other drug that affects dopamine release, reuptake, or receptor agonism, to carefully research the theoretical interactions posed by the combination, as well as any reports that are available from users who have already attempted the combination, because as the problems associated with MDAI, 5-APB, and particularily bk-MDMA used in combination with MXE have shown us, we do not fully understand the underlying mechanisms berhind methoxetamine's psychoactive action, or the risks posed by combining it with many other drugs.



Yeah, if only it were one of these two things, our troubles would be solved.

We can be fairly certain that MXE does not directly interact with serotonin as an agonist, or releasing agent from its structure. That it completely lacks any SSRI properties is less certain, although the weight of research on arylcyclohexylamines would not suggest that this is not the case. There are numerous mechanisms by which a drug can interact with Serotonin indirectly, including competitive interactions with serotonin reuptake, interaction with serotonin transporting proteins (SERT), and many others. It is possible that methoxetamine could be involved in one of these, although I would not be inclined to believe that it acts as a major contributor to its mechanism of action. However, minor mechanisms that are overshadowed by the drugs primary mechanisms can become more significant with the drug is co-administered with another psychoactive agent, and this would seem to be evident in the notable death in sweeden of the user who simultaneously injected high doses of MDAI and MXE intravenously, although this does not necessarily mean that the underlying negative interaction was related to serotonin.

The existance of a "dopamine syndrome" is still far from proven, but I would not rule it out given the number of reports of serotonin syndrome-like symptoms that have resulted from combining multiple drugs that interact with dopamine. There has been little research published on testing the validity of a "dopamine syndrome" model one way or the other, but research that will enhance our understanding of such phenomena is currently being conducted. I will provide links to the studies being performed on this type of interaction as soon as they are published, likely in early 2012, and perhaps even earlier if I get a chance to peer review the data myself.

Thankyou so much for taking the time to share your thoughts and information with us, NeuroPsyence. Are you someone who is personally tied to the studies you mention that are taking place? These sorts of studies could provide a missing link, and certainly clear up a lot of issues in my mind. Your posts are somewhat reassuring & comforting for me

 

[incognition]

Hello Bluelight. This is my first post here on the boards; I was just browsing this thread this morning, and I thought I would add some input from my research and experience.

Welcome!

 

[Pb109]

Sometimes I wonder what it is about MXE that I actually enjoy. I always feel drawn to it, make a habit out of it, think of it as something wonderful, however, I find the trip to often be depressing or uncomfortable, and often tell myself that I need to stop MXE altogether whilst I'm tripping on it.

But it's not that simple, because when I've lost all faith in it and tell myself that I'll try it once more, it offers me a breathtaking journey into a new world, entirely renewing my faith in it, yet afterwards I ask myself what it was about the trip that I enjoyed so much and can't put a finger on it...

I don't experience much euphoria, it doesn't offer anything practical like stimulants do, I can barely get any tasks done on it, and I don't even remember the trips very well afterwards as it makes my memory suck... it doesn't even help pass time since time feels like it's going slower than ever on it...not to mention the often unpleasant sound distortion/tinnitus and blurred vision.

Yet there's something which keeps me coming back every time, like an abusive spouse whicjh treats me badly yet apologizes and tries to make everything better when I'm about to leave...

It's such a difficult drug to understand and comprehend, with every trip having a different flavour to it - it can offer all the comfort in the world or be cold and unwelcoming.

Am I alone in experiencing this?

I know exactly what you mean. I've been taking this on and off for a few months now. Most of the time I use this now I feel it to be very cold. It's such a strange substance and it's getting to unpredictable now. Ive suffered 2 panic attacks on it and it scared the shit out of me. I still however get some amazing trips from it. On Saturday night I introduced a friend to it and we had an amazing time.

Iv only been buying 0.5 gram a week and this has been lasting 3 days. I have made a choice now and won't be buying it again. I have far to much going on in my life just now and I fear it's clouding my judgement on certain issues I have.

Another weird thing is since Ive started using it, I had no urge to take any other drug. MXE was the only thing on my mind.

 

[oSpherical]

I know exactly what you mean. I've been taking this on and off for a few months now. Most of the time I use this now I feel it to be very cold. It's such a strange substance and it's getting to unpredictable now. Ive suffered 2 panic attacks on it and it scared the shit out of me. I still however get some amazing trips from it. On Saturday night I introduced a friend to it and we had an amazing time.

Iv only been buying 0.5 gram a week and this has been lasting 3 days. I have made a choice now and won't be buying it again. I have far to much going on in my life just now and I fear it's clouding my judgement on certain issues I have.

Another weird thing is since Ive started using it, I had no urge to take any other drug. MXE was the only thing on my mind.

I can relate 100% to everything you've said, which makes me feel less alone.

I too have suffered 2 panic attacks on MXE, it's extremely unpleasant when you get into a mindset that something is wrong with your body, yet due to MXE's effects everything feels alien and weird, adding to the panic

And yes, when i first discovered MXE and was abusing it daily, I never even got a twinge of craving for another drug, even when I went out on low doses of MXE I'd avoid alcohol. And it wasn't just the drugs I no longer craved, it was bad habits of mine, instead I craved good habits and to get everything in my life into order. during the first month of using MXE I was certain that I found some sort of miracle cure for many of my problems. Eventually those habits returned and MXE was making me lazier than ever...

MXE has to be one of the most fascinating experiences available, but not always enjoyable...