The Big & Dandy Methoxetamine Thread - 4th Dose (don't overdose)

[sn23]

I'd suggest 3'-MeO-2-oxo-PCE according to Adders nomenclature in this thread.
The daggered numbers indicate positions on the benzene ring and normal numbers for the cyclohexyl ring.

 

[incognition]

Anyone smoked/vaped this? I know that's a common ROA for PCP & its ilk, but unaware of any reports of people doing this with MXE.

Yes, it's completely worthless. It works (not more efficient though) and comes on really quick and the effects are for some reason even more dopaminergic than usual. But the taste. THE TASTE! Imagine vaporizing ground up circuit boards together with assorted expired medicines. That's about it. Unless you want to know how robot medicine tastes like, stay away.

The problem is that the taste never goes away and is a central part of the experience.

 

[Albion]

Methoxetamine....Taste the Matrix?

 

[Splitz]

I absolutely love this stuff, but I must admit I feel people are being very naive when they lavish all this silly hyperbole onto it.

It's no more a wonder drug than anything else. People are becoming obsessed with this. I think any major dude was spot on to put a warning in the first post. This thread will inevitably fill up with worrying accounts of wreckless abuse and proclaimations of eternal love for a pile of powder

 

[Delsyd]

Why is there so much mention of seratonin syndrome with MXE. It doesn't act on seratonin thus should not be an issue. How is it causing SS then?
IMHO what some ppl are refering to as SS I would call an uncomfortable trip and a lot of ppl reporting SS are a) not familiar with the effects of dissociatives and b) not familiar with SS. SS is deadly in a lot of casEs. It seems like it's just a catch word for the MXE kids.

 

[Delsyd]

Splits what you're describing is normal when a great new drug appears, especially a psychedelic. Ive experienced the same with LSD and seen it happen with DOC and then 4 aco DMT.
It should be considered that most of these kids are just familiar with meph and when something like MXE comes along it would be life changing.

A question for atara, how sure are we that this is a dopamine agonist?

 

[Albion]

Why is there so much mention of seratonin syndrome with MXE. It doesn't act on seratonin thus should not be an issue. How is it causing SS then?
IMHO what some ppl are refering to as SS I would call an uncomfortable trip and a lot of ppl reporting SS are a) not familiar with the effects of dissociatives and b) not familiar with SS. SS is deadly in a lot of casEs. It seems like it's just a catch word for the MXE kids.

Do we actually have any proof that MXE doesn't act on serotonin at all, even indirectly? The fact that the methoxetamine related death was caused by mixing it with a drug that only acts on serotonin should be enough to point the finger squarely at MXE messing things up.

Also with regards to my experience with 5-APB and MXE, I've had countless methoxetamine experiences now of all dosages and experienced just about every different effect to be felt on it. My problems didn't occur immediately after taking the two drugs in combination. They occurred long after, hours (at good 3 hours) after the effects of the MXE should have worn off. I wasn't dissociated any more by that point, but had drifted into an different state of mind completely. Could have been SS, could have been something else completely, but was very much real. What's more, it took a good 48 hours for my mind and body to recover. My eyes were blown for the next day too. Muscles felt considerably weakened. I really can't emphasise enough that this was not just me getting spun for nothing. I was spun because of what I was experiencing happen to my body.


I don't know whether something was not getting metabolised that caused the physiological reaction. The massively extended duration of the MXE could suggest that it was just milling about, with the normal cycle of metabolism prevented from taking place as it should. That probably doesn't even make sense. I have no idea. But hopefully someone who does know what they're talking about might be able to back up my experience with proper, indisputable scientific insight. Pleease


People are always just gona say 'pfft he just had a bad trip, boo hoo' until a cause is identified for mishaps like this. If the cause turns out to be 'had a bad trip' then I shall eat my words and limbs.

 

[Delsyd]

Youre right, what youre describing does sound like more than just an MXE trip.
Were you still feeling the effects of the APB?

But i have heard reports (beyond this site) of people mixing it with MDMA, aMT, m1, mephedrone (i tried meph myself) and reporting no such effects.

I dont doubt you had an adverse reaction, i just dont belive it was SS. SS is just the new hip catch phrase in PDland lately.

As far as the death. Id attribute that more to IVing a huge dose of MDAI rather than MXE.

All i know about this drug is from what i heard from people trust. But nowhere did it mention that it acts on seratonin. Not that i know anything about this but i would guess it acts similarly to other NMDA agonists.

 

[Ayrios]

It should be considered that most of these kids are just familiar with meph and when something like MXE comes along it would be life changing.

This is the impression I'm getting with regard to the MXE mania here as of late. I look at the join dates of most of its wild proponents, and that pretty much answers my previous questions regarding the appeal of this drug. It's the most overrated new kid on the block since 5-MeO-MiPT in my opinion.

 

[Albion]

Youre right, what youre describing does sound like more than just an MXE trip.
Were you still feeling the effects of the APB?

But i have heard reports (beyond this site) of people mixing it with MDMA, aMT, m1, mephedrone (i tried meph myself) and reporting no such effects.

I dont doubt you had an adverse reaction, i just dont belive it was SS. SS is just the new hip catch phrase in PDland lately.

As far as the death. Id attribute that more to IVing a huge dose of MDAI rather than MXE.

All i know about this drug is from what i heard from people trust. But nowhere did it mention that it acts on seratonin. Not that i know anything about this but i would guess it acts similarly to other NMDA agonists.

Thanks for taking my word for it all. I do sort of like the aura of mystery that surrounds MXE. It's got heads scratching like no other, but it's really worrying. Even serotonin syndrome is a really recent discovery, with a surprisingly light history of research.

I remember Shambles saying he suspects that there probably is an equivalent dopamine version (dopamine syndrome?) that may follow the same basic principle. If this does exist, it seems a much more likely candidate to explain my experience. Could possibly explain why MXE and all those heavy releasers/SSRIs get on. Perhaps 5-APB is more dopamine orientated?

 

[any major dude]

Why is there so much mention of seratonin syndrome with MXE. It doesn't act on seratonin thus should not be an issue. How is it causing SS then?
IMHO what some ppl are refering to as SS I would call an uncomfortable trip and a lot of ppl reporting SS are a) not familiar with the effects of dissociatives and b) not familiar with SS. SS is deadly in a lot of casEs. It seems like it's just a catch word for the MXE kids.

Serotonin Syndrome & vasoconstriction get blamed for every moderately negative aspect of a psychedelic/dissociative experience these days Its almost like the new "cyanide in your acid, man"

While i don't want to discount anyone's negative experience as illegitimate, because these things certainly are jarring, i really dislike the propensity for self-diagnosis of rare conditions by people not terribly familiar with said conditions...

There do seem to be a lot of people combining MXE with various monamine releasers & not reporting problems. The MXE/MDAI overdose death was the result of around 100mg MXE & roughly half a gram of MDAI being injected intravenously. This is a ridiculous dose and an incredibly stupid thing to do, and trying to extrapolate pharmacological action from that incident is ill-advised at best.

All this being said, lots of these substances (MDAI, 5/6-APB, MXE) have never been tested in humans, & some not even in animals. So if you go combining experimental drugs that are entirely new in the human experience, step your way up slowly (if at all) or you're bound to encounter negative side effects. What else did you think would happen?

 

[Delsyd]

^good post AMD.

And just to reiterate, When combining it should be done slowly, in reasonable doses.

my meph combo was 1 250mg bomb (a low dose by most people standard) followed by roughly 80mg of MXE.
And the experience was awesome.

 

[Albion]

Serotonin Syndrome & vasoconstriction get blamed for every moderately negative aspect of a psychedelic/dissociative experience these days Its almost like the new "cyanide in your acid, man"

While i don't want to discount anyone's negative experience as illegitimate, because these things certainly are jarring, i really dislike the propensity for self-diagnosis of rare conditions by people not terribly familiar with said conditions...

There do seem to be a lot of people combining MXE with various monamine releasers & not reporting problems. The MXE/MDAI overdose death was the result of around 100mg MXE & roughly half a gram of MDAI being injected intravenously. This is a ridiculous dose and an incredibly stupid thing to do, and trying to extrapolate pharmacological action from that incident is ill-advised at best.

All this being said, lots of these substances (MDAI, 5/6-APB, MXE) have never been tested in humans, & some not even in animals. So if you go combining experimental drugs that are entirely new in the human experience, step your way up slowly (if at all) or you're bound to encounter negative side effects. What else did you think would happen?

I actually decided to take MXE with 5-APB after reading a report on bluelight of an amazing multi-dimensional experience. Not exactly a reliable report but tbh I didn't need much persuasion. I genuinely thought nothing could go wrong, cos nothing ever had done before. Argh. I do realise how complacent I was, especially with MXE. I really paid for my attitude.

I don't mean to self-diagnose, more to throw an idea out there, however crude. I've been desperate to find out what happened, and can't really draw a line under it until then.

 

[cocoabud]

i've noticed that mxe has become rather clumpy in my little glass jar home over the past month. i guess i need to find a couple of those little moisture control pouches to toss in there. hope it is ok to ask but does anyone know where to get those things?

 

[any major dude]

Don't think my post was specifically directed at you. As delsyd mentioned its been a trend on BL at large for some time now. And i really think it does people a disservice.

I actually decided to take MXE with 5-APB after reading a report on bluelight of an amazing multi-dimensional experience. Not exactly a reliable report but tbh I didn't need much persuasion. I genuinely thought nothing could go wrong, cos nothing ever had done before. Argh. I do realise how complacent I was, especially with MXE. I really paid for my attitude.

I don't mean to self-diagnose, more to throw an idea out there, however crude. I've been desperate to find out what happened, and can't really draw a line under it until then.

There's your problem

And as for what actually happened... I wouldn't hold my breath on getting a reliable answer. There are just too many unknowns....
The combination could've saturated a metabolic pathway that led to some of the less fun metabolites hanging around for longer than normal, one drug's presence could've altered the metabolism of the other a la cocaethylene, there could be any number of contraindications regarding those substances that we don't know about yet, you could've taken too many drugs & freaked out then were unable to properly integrate the experience, or it could just be another one for the YMMV files... All this is pretty rampant speculation on my part, and i couldn't list any one of those as more likely than the rest, or a bunch of options i didn't even think of.

 

[Albion]

Hmm...Perhaps I'll revisit the subject 10 years later...and probably discover that still no one knows 8)

Frustrating...but you're right of course. I wish it were all just as simple as Serotonin Syndrome or Serotonin Syndrome.

MXE you so crazy...

 

[oSpherical]

I'm going to see if any of the magic has come back after a month and a half long hiatus from this chemical. I feel guilty for getting hold of it again, but a vendor was having such a good deal that I couldn't resist.

Is it safe to take MXE tonight if I had 20mg MPA this afternoon? I'd rather not mix MXE with anything, but it seems pointless to wait another day to take it if the MPA is mostly out of my system...

 

[ColtDan]

MXE is some very strange stuff

 

[Albion]

Is it safe to take MXE tonight if I had 20mg MPA this afternoon? I'd rather not mix MXE with anything, but it seems pointless to wait another day to take it if the MPA is mostly out of my system...

Saucy answered this pretty well back on the first page:

Baaaaddd idea. MXE combinations seem to be commonly linked with serotonin syndrome, which is understandable given the problems people have had in combining it with MDAI, 5-APB, bk-MDMA, etc., but that would not be your greatest worry with your proposed combination.

MPA likely binds to SERT in a very similar manner to methamphetamine, and it probably competes directly with dopamine reuptake in the neuronal synaptic cleft too. And moreover, It's likely a damn good dopamine releasing agent if its structural similarity to methoxetamine is any indication. Combine it with a dopamine reuptake inhibitor like MXE and you are just asking for trouble.

 

[socalthizzn]

Tbh idk man. I didnt dose everything within close time. Acid at 3pm, mdma at 7, 8 & 10:30 take the mxe around 12:30 none of wich were absurdly high dose. And dont 6-apb and mdma work differently in the brain?
I also didnt drive while peaking i drove 7 hours after taking my last bump. Sure i was manic but not high anymore.

How can you actually get away with taking so many drugs together and not get serotonin syndrome? I got something approaching serotonin syndrome combining it with an average dose of MDAI, and my experience with 5-APB was infinitely worse.

AND you somehow managed to drive a car whilst under the influence of LSD, MDMA and methoxetamine. I suspect your body functions very differently to the average person (And I can sorta see why).

I encounter problems mixing MXE with one drug alone, and I'd probably be dead if I tried to attempt the combination you took. Safe to say this would be the same case for most other people?

My point being that for whatever reason, you're the exception to the rule, and it'd be dangerous for people to think otherwise.