I find MXE to be a hard one to pin down. It's been just over over three years since my first trials, and I have used intermittently throughout those three years. Space between uses has allowed for lack of tolerance build up. All dosages have been oral except in some cases when insufflation has been used, usually just for the fun of it. The first thing I've noticed is the potential for dysphoria. I think I've had an equal number of dysphoric experiences as I've had euphoric experiences on it. All of them have been in appropriate sets/settings. I can't quite find the confounding variable. Second thing I've noticed is that the same dosage will yield different subjective effects each time I dose. For example, in some cases 30-50mg gives me psychedelic headspace with unusual thought patterns, point of view displacement, and appreciation for art; other times the dosage will feel numbing and confusing with little other psychoactive activity. Some times I can feel quite healing thought patterns being produced, other times they tend toward the negative. Sometimes it relieves anxiety, other times it induces anxiety.
Main thing I'd note is that MXE has very little inherent character of its own. It is best used to modulate other drugs. When I take MXE by itself I find the effects by turns dull, uninteresting, confusing, empty. For example, at low doses, I find it uninteresting because it mostly acts as a stimulant. Which is fine, but it's not what I'm looking for out of dissociatives. At high doses I mostly get confused and worried. On the other hand, my most positive experiences have come from combining it. Now here is where things with MXE's lack of inherent character get mouth-wateringly intriguing. Because you can make MXE do or be almost anything. For example, if you'd like a functional psychedelic high for the day, look no further than combining a micro-dose of LSD (maybe 10-20mcg) with a small dose of MXE and some cannabis. For more psychedelia, you can up the doses on either the LSD or the MXE, or both, but take note that functionality will quickly decrease as the dosages are increased and you can find yourself in a full-fledged trip pretty easily. Of course a full tripping dose of LSD combined with MXE is itself quite good, but some days just aren't meant to shatter your mind, so the micro-dose procedure is a nice middle ground for those who like getting psychedelic.
I know this will not necessarily be a popular opinion but I find that MXE mixes great with alcohol and cannabis. And I'm not talking about one or two beers for the night, I'm talking about a night of drinking. The experience will be different depending on how much MXE you dose. I've found that dosing a small amount of MXE on a night of drinking can have excellent effects on sociability, euphoria, and energy. In this capacity it acts much like a stimulant, and I find it sharpens the drunken high and takes away that sickly element of being drunk. Dosing a full dose of MXE during a night of drinking is another beast altogether, but the combination is seriously euphoric and basically becomes a psychedelic drunkenness, particularly when mixed with plenty of cannabis. MXE preserves what I like about alcohol's psychoactive effects and minimizes the felt side-effects. Mind you, this combination is severely dehydrating and one should approach it with due caution. If I'm not careful with it I can have dehydration effects for a week afterward. I would never advise anyone to mix alcohol and MXE in the way I do, as everyone needs to know their own limits and how they respond to drugs. Again, the combination is severely dehydrating and so appropriate cautions should be taken.
Anyway, these have been some of my findings with MXE. I originally delved into MXE with the intention of using it in a more entheogenic fashion but I have simply not found it to be a useful material in that regard. It never gives me too much insight into anything, except when mixed with mushrooms but then I just assume it's mostly the mushrooms.