This is very interesting discussion based around a very interesting drug.
For me MXE beats ketamine on so many levels - it is more profoundly psychedelic, it is more uplifghting, I find I can take lessons out of my experiences that are lost to the k chaos etc. also, as a Buddhist, I believe that in a very real sense the world we perceive is projection of our own mind. Quantum physics is now coming very close to a similar realisation. Years of meditation and use of psychedelic drugs have suggested to me that this really is the case. However, for me the realisation has also dawned on me that the idea I have of myself is just a thought, nothing more. So there is no real self to be creator of anything, only mind which is itself ultimately empty too. Sorry for the deep Buddhist philosophical rant, none of you of course have to believe me, but these are the conclusions I have come to through my own practices and experiences. And MXE is one drug that I really believe, when respected, can teach us a lot about the true nature of things, of consciousness and so forth.
I used to do huge lines of MXE and spend days in a manic-delusional state, at one time nearly killing myself by throwing myself down the stairs. I now take no more that 50mg at a time and find that really is plenty. You can always top up a little bit a few hours later if you really need to. Such a shame this is banned in UK, there really is no comparison between current NMDA antagonists available on the RC scene in the UK (e.g. MXP).
I also believe there is more genuine therapeutic potential with MXE than with ketamine, partly because it feels more genuinely psychedelic and also because it seems easier to stay more lucid through the experience.