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The Big & Dandy Medication/Supplement Interaction Thread

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I've been on Prozac and eaten loads of acid with no reduction of increase in effect at all that I could tell.
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I agree, I've been on Prozac multiple times while on acid and felt no additional effects.
 
I just can say that I'm into the same opinion...I tried a few times trippin on lsd or psilocibin in combination with SSRIs...it doesn't work that good at all...
Sure you had some intensive effects but you'll never get that deep hallucinogen,deep intensive trip that you would probably get if you wouldn't take SSRIs....
sorry for my english I'm german...
Greets
MistaMeth
 
rc's, acid and anti-d's

SWIM was going to try 2c-e and acid again but SWIM was wondering if celexa decreases the effectiveness of psychedelics. SWIM has noticed meth, alcohol and coke all have mild effects since SWIM has started celexa(why is this?). SWIMdoesn't want to waste money on something that isn't worthwhile.
 
Yes, it will. SSRIs affect the serotonin system and typically make psychedelics and stimulants much less effective. This is because psychedelics and many stimulants work through the serotonin system.
 
Well, there was a case a few months ago, mentioned here and on other boards, where someone managed to come down with serotonin syndrome after doing 4-AcO-DMT three days in a row while on a SSRI. The circumstances show that it takes quite a bit to cause such an interaction, but it's still a possibility with frequent and/or high dosing.

By most accounts, psilocybin typically isn't affected by SSRIs as badly as LSD. I have a few friends on SSRIs who still require a lower dose of shrooms than I do for the same effect, and one who can still trip but now requires 5g to have a worthwhile experience. Individual brain chemistry still factors into how the interaction works, so there's no way to tell till you dose.
 
Xorkoth said:
Yes, it will. SSRIs affect the serotonin system and typically make psychedelics and stimulants much less effective. This is because psychedelics and many stimulants work through the serotonin system.
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I would beg to differ.....anyway.
 
Mushies + E + MAOI ?

Like the title says...tomorrow night this is happening....to increase the effects of the mushies (2g each dried), we were going to have an E tab, but I can't find much info about the use of a mild MAOI with the E. Are there any contraindications of using an MAOI with the E?

I was thinking of a strong solution of the st johns wort (readily available) to increase the effects of the mushies...as long as there are no dangers of the MAOI with the E.....

Are would the 2g of mushies be enough along with the E.....
 
willow11 said:
Ya, MDMA should not be combined with an MAOI. Any PEA is dangerous taken this way.
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Well, it depends on what MAO enzyme you are inhibiting. Inhibiting MAO-A with a monoamine releaser (MDMA) is very foolish.

But, inhibiting MAO-B with a phenylethylamine that does not releaser monoamines (ie mescaline) is not as dangerous (although very intense potentiation could occur).*

*nobody should recommend combining MAOIs with psychedelics that are already orally active.
 
^ Well most of the MAOIs that can be easily gotten hold of are MAO-A inhibitors, so I think a sweeping generalization in this case isn't that bad a thing (especially if you consider the only MAO-B inhibitor that's generally mentioned is selegeline & it's a clinically significant MAO-A inhibitor at 2-3 times the usual recommended dose)

So: DO NOT COMBINE ANY MAOI WITH MDMA/MDA

If you have a decent knowledge of pharmacology/enzyme kinetics, you might consider tinkering - I certainly wouldn't...
 
Well, it is done, and I have some incredible results to tell you all about....as soon as I can type it all up, in a couple hours. right now I have to go cook some dinner for the family....more to come.

Think level 4 results8o =D (and my first time to boot!).
 
samadhi_smiles said:
Well, it depends on what MAO enzyme you are inhibiting. Inhibiting MAO-A with a monoamine releaser (MDMA) is very foolish.

But, inhibiting MAO-B with a phenylethylamine that does not releaser monoamines (ie mescaline) is not as dangerous (although very intense potentiation could occur).*

*nobody should recommend combining MAOIs with psychedelics that are already orally active.
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If you are a psychonaut, I say by all means take a maoi with some LSD or mushrooms (or some other various tryptamine)

you cant replicate those types of experience regaurdless of how much/large of a dose of the first you eat.
 
^^^Agreed. MAO inhibition (at least with harmala alkaloids or whatever MAOIs are found in cacti) changes the trip not only quantitatively in terms of intensity but also qualitatively in terms of headspace.

MAOIs can safely be combined with most tryptamines, and some phenethylamines. If you want to play it safe, don't combine an MAOI with any psychedelic that is either a monoamine releaser or a potent MAOI in its own right.
 
5-HT2 said:
^^^Agreed. MAO inhibition (at least with harmala alkaloids or whatever MAOIs are found in cacti) changes the trip not only quantitatively in terms of intensity but also qualitatively in terms of headspace.

MAOIs can safely be combined with most tryptamines, and some phenethylamines. If you want to play it safe, don't combine an MAOI with any psychedelic that is either a monoamine releaser or a potent MAOI in its own right.
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I still dont quite udnerstand how MAOinhibination actualy changes the trip (physicaly.. science of it)

care to explain? I know it stops enzymes in the liver from breaking down monoamines... but what does that equate to in experiene?
 
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